Wound dressing comprising hyaluronic acid-calcium and polylysine and manufacturing method therefor

Abstract

The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a manufacturing method therefor, the method comprising: (1) a step for adjusting each of the pH values of a hyaluronic acid-calcium salt and a polylysine aqueous solution to 8.4 or higher, and then mixing the hyaluronic acid-calcium salt and the polylysine aqueous solution to obtain a mixture liquid; and (2) obtaining a wound dressing from the mixture liquid obtained in Step (1).

1 . A wound dressing comprising hyaluronic acid-calcium and polylysine. 
     
     
         2 . The wound dressing according to  claim 1 , comprising the hyaluronic acid-calcium and polylysine in a ratio of 4:1 to 1:1.5 by weight. 
     
     
         3 . The wound dressing according to  claim 1 , comprising the hyaluronic acid-calcium and polylysine in a ratio of 2:1 to 4:3 by weight. 
     
     
         4 . The wound dressing according to  claim 1 , comprising the hyaluronic acid-calcium and polylysine in a ratio of 2:1 to 1:1.5 by weight. 
     
     
         5 . The wound dressing according to  claim 1 , wherein the hyaluronic acid has a molecular weight of 2×10 6  to 3×10 6  Da. 
     
     
         6 . The wound dressing according to  claim 1 , wherein the wound dressing is in a form of liquid, foam or film. 
     
     
         7 . A method for preparing a wound dressing according to  claim 1 , comprising:
 (1) mixing an aqueous hyaluronic acid-calcium salt adjusted to pH 8.4 or higher with an aqueous polylysine adjusted to pH 8.4 or higher, and   (2) obtaining a wound dressing from a mixed solution obtained in Step (1).   
     
     
         8 . The method according to  claim 7 , wherein each of the pH values of the aqueous hyaluronic acid-calcium salt and the aqueous polylysine is adjusted to a range of 8.4 to 9.0 in Step (1). 
     
     
         9 . The method according to  claim 7 , wherein a liquid-type wound dressing is obtained from the mixed solution in Step (2). 
     
     
         10 . The method according to  claim 7 , wherein the mixed solution is freeze-dried to obtain a foam-type wound dressing in Step (2). 
     
     
         11 . The method according to  claim 7 , wherein the mixed solution is applied onto a substrate or poured into a mold, and then dried to obtain a film-type wound dressing in Step (2).