Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes)

Abstract

Compounds of the general formula (I):or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

1 - 42 . (canceled) 
     
     
         43 . A method of treating abnormal cell growth in a mammal, the method comprising administering to the mammal a therapeutically effective amount of the compound: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         44 . The method of  claim 43 , wherein said compound or salt is a component of an antibody-drug conjugate. 
     
     
         45 . The method of  claim 43 , wherein said compound or salt is a component of a particle-based delivery system. 
     
     
         46 . The method of  claim 43 , wherein the abnormal cell growth is cancer. 
     
     
         47 . The method of  claim 43 , wherein said cancer is lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head or neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer, cancer of the anal region, stomach cancer, colon cancer, breast cancer, uterine cancer, carcinoma of the fallopian tubes, carcinoma of the endometrium, carcinoma of the cervix, carcinoma of the vagina, carcinoma of the vulva, Hodgkin's Disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, cancer of the thyroid gland, cancer of the parathyroid gland, cancer of the adrenal gland, sarcoma of soft tissue, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, lymphocytic lymphomas, cancer of the bladder, cancer of the kidney or ureter, renal cell carcinoma, carcinoma of the renal pelvis, neoplasms of the central nervous system (CNS), primary CNS lymphoma, spinal axis tumors, brain stem glioma, or pituitary adenoma. 
     
     
         48 . A method of upregulating the activity of STING in a mammal, comprising the step of administering to said mammal an effective amount of the compound: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         49 . A method of increasing interferon-beta levels in a mammal, comprising the step of administering to said mammal an effective amount of the compound: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof.