Antimicrobial coatings for medical dressings and dry antimicrobial medical dressings therefrom

Abstract

Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns, and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (R1O)3Si—R2—Z, an organic amine R9R10R11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

We claim: 
     
         1 . A medical dressing comprising:
 a nonwoven or woven substrate treated with an antimicrobial coating composition comprising a mixture of 3-aminopropyltriethoxysilane, triethanolamine, and water,   wherein the medical dressing exhibits residual antimicrobial efficacy against at least one of  E. coli, S. aureus , or  S. epidermidis.      
     
     
         2 . The medical dressing of  claim 1 , wherein the aqueous antimicrobial coating composition consists essentially of 5% v/v 3-aminopropyltriethoxysilane, 5% v/v triethanolamine, remainder water. 
     
     
         3 . The medical dressing of  claim 1 , wherein the aqueous antimicrobial coating composition consists essentially of 10% v/v 3-aminopropyltriethoxysilane, 0.28% v/v triethanolamine, remainder water. 
     
     
         4 . The medical dressing of  claim 1 , wherein the substrate comprises a cellulose wiper. 
     
     
         5 . The medical dressing of  claim 1 , wherein the substrate comprises polyester gauze. 
     
     
         6 . The medical dressing of  claim 1 , wherein the substrate comprises cotton gauze. 
     
     
         7 . A method of producing a medical dressing, the method comprising:
 treating a substrate with an aqueous antimicrobial coating composition comprising a mixture of 3-aminopropyltriethoxysilane, triethanolamine, and water,   wherein the medical dressing exhibits residual antimicrobial efficacy against at least one of  E. coli, S. aureus , or  S. epidermidis.      
     
     
         8 . The method of  claim 7 , wherein the substrate comprises a woven or a nonwoven. 
     
     
         9 . The method of  claim 7 , wherein the medical dressing is selected from the group consisting of adhesive bandages, gauze rolls, gauze pads, wraps, sponge material, breathable films, patient gowns, examination gowns, surgical gowns, and disposable dry wiper substrates. 
     
     
         10 . The method of  claim 7 , wherein the aqueous antimicrobial coating composition consists essentially of 5% v/v 3-aminopropyltriethoxysilane, 5% v/v triethanolamine, remainder water. 
     
     
         11 . The method of  claim 7 , wherein the aqueous antimicrobial coating composition consists essentially of 10% v/v 3-aminopropyltriethoxysilane, 0.28% v/v triethanolamine, remainder water. 
     
     
         12 . The method of  claim 7 , wherein treating a substrate with an aqueous antimicrobial coating composition further comprises a dip coating or spray coating of the substrate with the aqueous antimicrobial coating composition. 
     
     
         13 . The method of  claim 7 , wherein treating a substrate with an aqueous antimicrobial coating composition results in saturation of the substrate with the aqueous antimicrobial coating composition. 
     
     
         14 . The method of  claim 7 , wherein the substrate comprises a cellulose wiper, a polyester gauze or cotton gauze. 
     
     
         15 . The method of  claim 7 , further comprising drying or curing the aqueous antimicrobial coating composition in the substrate after the treating. 
     
     
         16 . The method of  claim 15 , wherein drying comprises ambient, passive drying to provide a medical dressing perceived as dry to the touch. 
     
     
         17 . A medical dressing comprising:
 a nonwoven or woven substrate; and   an antimicrobial coating composition thereon, the antimicrobial coating composition comprising at least one organosilane selected from the group consisting of octadecyldimethyl-(3-trimethoxysilylpropyl) ammonium chloride, 3 -chloropropyltrimethoxysilane, 3-aminopropyltriethoxysilane, and mixtures thereof,   wherein the medical dressing exhibits residual antimicrobial efficacy against at least one of  E. coli, S. aureus , or  S. epidermidis.      
     
     
         18 . The medical dressing of  claim 17 , wherein the antimicrobial coating composition comprises an aqueous mixture of octadecyldimethyl-(3-trimethoxysilylpropyl) ammonium chloride, 3-chloropropyltrimethoxysilane, and 3 -aminopropyltriethoxysilane. 
     
     
         19 . The medical dressing of  claim 18 , wherein the antimicrobial coating composition further comprises triethanolamine. 
     
     
         20 . The medical dressing of  claim 19 , wherein the antimicrobial coating composition consists essentially of octadecyldimethyl-(3-trimethoxysilylpropyl) ammonium chloride, 3-chloropropyltrimethoxysilane, 3 -aminopropyltriethoxysilane, triethanolamine, and water.