Prebiotic Oral Care Compositions Containing Carboxylic Acids

Abstract

The present invention provides an oral care composition comprising a carboxylic acid of the formula: wherein: R 1 is H, or is a substituted or unsubstituted alkyl group; and R 2 is H, OH, or NH 2 ; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora.

1 . An oral care composition comprising monomethyl succinate:
 wherein the composition is effective for:   (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of  S. mitis  bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria;   (b) selectively promoting, in an oral cavity, biofilm formation by  S. mitis  bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or   (c) maintaining and/or re-establishing a healthy oral microbiota comprising  S. mitis.      
     
     
         2 - 27 . (canceled) 
     
     
         28 . The oral care composition of  claim 1 , wherein the composition is a dentifrice, a toothpaste, a gel, a tooth powder, a mouthwash, a mouthrinse, a lozenge, a tablet, a spray, a gum, or a film. 
     
     
         29 . (canceled) 
     
     
         30 . The oral care composition of  claim 1 , wherein the species of bacteria that has beneficial effects on oral health is selected from  Streptococcus mitis, Streptococcus sahvarius, Streptococcus sanguinis, Actinomyces viscosus, Veillonella parvula, Streptococcus gordonii, Capnocytophaga sputigena, Actinomyces naeslundii  and combinations thereof. 
     
     
         31 . The oral care composition of  claim 1 , for use in preventing one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries. 
     
     
         32 . A method of selectively promoting, in an oral cavity of a subject:
 (a) growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; or   (b) biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria;   the method comprising contacting an oral cavity of the subject with an oral care composition according to  claim 1 .   
     
     
         33 . A method of maintaining and/or re-establishing a healthy oral microbiota in a subject, the method comprising contacting an oral cavity of the subject with an oral care composition according to  claim 1 . 
     
     
         34 . A method of preventing one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries in a subject, the method comprising contacting an oral cavity of the subject with an oral care composition according to  claim 1 . 
     
     
         35 - 37 . (canceled)