Implantable device for delivery of therapeutic substances to the eye

Abstract

Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and a recess configured to support the composition. At least one of the portions includes an impermeable polymer and at least one other portion includes a rate-limiting water-permeable polymer. The rate-limiting water-permeable polymer allows for transportation of the active agent to an exterior of the device.

1 - 26 . (canceled) 
     
     
         27 . A device,
 wherein the device is configured for implantation into the eye episclerally or supraconjunctivally,   wherein the device comprises:
 a first portion comprising a rate-limiting water-permeable polymer, and 
 a second portion comprising a prostaglandin salt, 
 wherein the first portion is configured to allow the prostaglandin salt to pass therethrough at a rate of 0.00025 μg/h to 0.015 μg/h when the device is implanted into the eye, and 
   wherein the device is configured to release at least 70% of the latanoprost free acid salt over a period of at least 30 days.