Compositions and methods for application over skin

Abstract

Disclosed herein are compositions that can form a covering, layer, film, device, and/or prosthetic skin that can be comfortably worn to provide skin barrier function, skin hydration and therapeutic and aesthetic benefits. The present invention provides novel compositions that have low tackiness and form quickly, resulting in a wearable, comfortable (maintains temperature and humidity), breathable, thin, optically invisible, cosmetically elegant, flexible, stretchable, elastic and body-movement conforming, yet long-lasting covering, layer, film, device, and/or prosthetic skin on the skin or any other body surface. The present invention provides novel compositions that can form a covering, layer, film, device, and/or prosthetic skin that works for extended periods in excess of about 24 hours, while retaining function during and after exercising, showering and swimming (in sea-water, fresh water and chlorinated water), steam room (heat at high humidity), and sauna (heat at low humidity).

1 . A composition for the in-situ formation of a layer over the skin of a subject, comprising one or more crosslinkable polymers. 
     
     
         2 - 20 . (canceled) 
     
     
         21 . A composition for the in-situ formation of a layer over the skin of a subject, wherein said composition is a two-part composition comprising a first and a second part;
 wherein said first part comprises as ingredients:
 Polymer A, which is one or more organopolysiloxane(s) having on average at least two alkenyl-functional groups and having a viscosity of about 10,000 to about 2,000,000 cSt at about 25° C.; 
 Polymer B, which is one or more organopolysiloxane(s) having on average at least two Si—H units and having a viscosity of about 2 to about 500,000 cSt at about 25° C.; 
   wherein said second part comprises as ingredients:
 a catalyst that facilitates crosslinking of the Polymers A and B; and 
 Polymer C, which is one or more organopolysiloxane(s) having on average at least one alkenyl-functional group and having a viscosity of about 0.7 to about 10,000 cSt at about 25° C. 
   
     
     
         22 . The composition of  claim 21 , wherein said Polymer A has an average molecular weight of greater than about 60,000 Da, greater than about 72,000 Da, greater than about 84,000 Da, greater than about 96,000 Da, greater than about 100,000 Da, greater than about 140,000 Da, or greater than about 150,000 Da, and
 wherein said Polymer A has an average molecular weight of less than about 500,000 Da, less than about 200,000 Da, less than about 190,000 Da, less than about 180,000 Da, less than about 170,000 Da, or less than about 160,000 Da.   
     
     
         23 . The composition of  claim 21 , wherein said Polymer B has an average molecular weight of greater than about 400 Da, greater than about 500 Da, greater than about 800 Da, greater than about 1,200 Da, greater than about 1,800 Da, or greater than about 2,000 Da, and
 wherein said Polymer B has an average molecular weight of less than about 500,000 Da, less than about 250,000 Da, less than about 140,000 Da, less than about 100,000 Da, less than about 72,000 Da, less than about 62,700 Da, less than about 49,500 Da, less than about 36,000 Da, less than about 28,000 Da, or less than about 17,200 Da.   
     
     
         24 . The composition of  claim 21 , wherein said Polymer C has an average molecular weight of greater than about 180 Da, greater than about 500 Da, greater than about 800 Da, greater than about 1,500 Da, greater than about 3,000 Da, or greater than about 6,000 Da, greater than about 9,400 Da, and
 wherein said Polymer C has an average molecular weight of less than about 65,000 Da, less than about 50,000 Da, less than about 45,000 Da, less than about 30,000 Da, or less than about 17,500 Da.   
     
     
         25 . The composition of  claim 21 , wherein said Polymer A has an average molecular weight of about 155,000 Da; and/or
 wherein said Polymer B has an average molecular weight of between about 2,200 and about 6,000 Da; and/or   wherein said Polymer C has an average molecular weight of about 10,000 Da.   
     
     
         26 . The composition of  claim 21 , wherein said first part comprises as ingredients:
 (i) about 5 to about 90% by weight of said Polymer A; about 5 to about 75% by weight of said Polymer B; and about 0 to about 25% by weight of a reinforcing component; or   (ii) about 50 to about 90% by weight of said Polymer A; about 5 to about 30% by weight of said Polymer B; and about 5 to about 15% by weight of a reinforcing component.   
     
     
         27 . The composition of  claim 21 , wherein said second part comprises as ingredients:
 (i) about 0.01 to about 20% by weight of said Polymer C and about 0.005 to about 0.05% by weight of said catalyst; or   (ii) about 0.5 to about 10% by weight of said Polymer C and about 0.01 to about 0.03% by weight of said catalyst.   
     
     
         28 . The composition of  claim 21 , wherein said first part comprises as ingredients: about 5 to about 90% by weight of said Polymer A; about 5 to about 75% by weight of said Polymer B; and about 0 to about 25% by weight of a reinforcing component; and wherein said second part comprises as ingredients: about 0.01 to about 20% by weight of said Polymer C and about 0.005 to about 0.05% by weight of said catalyst. 
     
     
         29 . The composition of  claim 21 , wherein the molar ratio of Si—H functional group from said Polymer B to alkenyl-functional group from said Polymer A is from about 60:1 to about 1:5; and/or
 wherein the molar ratio of Si—H functional group from said Polymer B to alkenyl-functional group from said Polymer A is about 45:1 to about 15:1; and/or 
 wherein the molar ratio of Si—H functional group from said Polymer B to alkenyl-functional group from said Polymer C is from about 60:1 to about 1:5; and/or 
 wherein the molar ratio of Si—H functional group from said Polymer B to alkenyl-functional group from said Polymer C is about 45:1 to about 15:1; and/or 
 wherein the molar ratio of alkenyl-functional group from said Polymer A to alkenyl-functional group from said Polymer C is about 100:1 to about 1:100; and/or 
 wherein the molar ratio of alkenyl-functional group from said Polymer A to alkenyl-functional group from said Polymer C is about 10:1 to about 1:10. 
 
     
     
         30 . The composition of  claim 21 , wherein said Polymer C is selected from vinyl terminated polydimethylsiloxane, vinyl terminated diphenyl siloxane-dimethylsiloxane copolymers, vinyl terminated polyphenylmethylsiloxane, vinylphenylmethyl terminated vinylphenylsiloxane-phenylmethylsiloxane copolymer, vinyl terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer, vinyl terminated diethyl siloxane-dimethylsiloxane copolymer, vinylmethylsiloxane-dimethylsiloxane copolymer, trimethylsiloxy terminated, vinylmethylsiloxane-dimethylsiloxane copolymers, silanol terminated, vinylmethylsiloxane-dimethylsiloxane copolymers, vinyl terminated, vinyl gums, vinylmethylsiloxane homopolymers, vinyl T-structure polymers, monovinyl terminated polydimethylsiloxanes, vinylmethylsiloxane terpolymers, vinylmethoxysilane homopolymers, or combinations thereof. 
     
     
         31 . The composition of  claim 30 , wherein said Polymer C is vinyl dimethicone. 
     
     
         32 . The composition of  claim 21 , wherein said Polymer C has a viscosity of greater than about 0.7 cSt, greater than about 1 cSt, greater than about 6 cSt, greater than about 10 cSt, greater than about 20 cSt, greater than about 50 cSt, greater than about 100 cSt, or greater than about 200 cSt at about 25° C., and wherein said Polymer C has a viscosity of less than about 10,000 cSt, less than about 5,000 cSt, less than about 4,000 cSt, less than about 2,000 cSt, less than about 1,000 cSt, or less than about 500 cSt at about 25° C. 
     
     
         33 . The composition of  claim 21 , wherein said Polymer C has a viscosity of about 250 cSt at about 25° C. 
     
     
         34 . A composition as defined in  claim 21  for use in a method for modifying skin function, wherein the method comprises applying the composition to the subject in need thereof. 
     
     
         35 . A kit comprising the composition of  claim 21  and instructions for use. 
     
     
         36 . The kit of  claim 35 , wherein the kit further comprises a cleanser suitable for removing said layer from the skin; and/or one or more brush(es), swab(s), and/or mirror(s).