Composition for Improving Vascular Endothelial Function or Improving Blood Flow in Peripheral Blood Vessels

Abstract

The present invention provides a composition for improving vascular endothelial function or improving blood flow in peripheral blood vessels, comprising, as an active ingredient, an ingredient derived from a turmeric. The present invention relates to a composition for improving vascular endothelial function or improving blood flow in peripheral blood vessels, comprising, as an active ingredient, at least one of turmeronol A, turmeronol B and bisacurone. The present invention also relates to a composition for improving vascular endothelial function or improving blood flow in peripheral blood vessels, comprising a turmeric as an active ingredient.

1 - 8 . (canceled) 
     
     
         9 . A method for improving vascular endothelial function, comprising:
 administering at least one of turmeronol A, turmeronol B and bisacurone to a subject in need of improving vascular endothelial function; and   improving the vascular endothelial function in the subject.   
     
     
         10 . The method according to  claim 9 , wherein the administration comprises administering a turmeric extract extracted with at least one extraction solvent selected from water and a hydrophilic organic solvent, the turmeric extract comprising the at least one of turmeronol A, turmeronol B and bisacurone. 
     
     
         11 . The method according to  claim 9 , wherein the administration comprises administering 20 μg or more turmeronol A and turmeronol B in total to the subject per day. 
     
     
         12 . The method according to  claim 9 , wherein the administration comprises administering 17 μg or more turmeronol A to the subject per day. 
     
     
         13 . The method according to  claim 9 , wherein the administration comprises administering 5 μg or more turmeronol B to the subject per day. 
     
     
         14 . The method according to  claim 9 , wherein the administration comprises administering 80 μg or more bisacurone to the subject per day. 
     
     
         15 . The method according to  claim 9 , wherein the administration comprises administering less than 30 mg of curcumin to the subject per day. 
     
     
         16 . A method for improving vascular endothelial function, comprising:
 administering a turmeric to a subject in need of improving vascular endothelial function; and   improving the vascular endothelial function in the subject,   wherein the turmeric is neither a combination of a turmeric with a clove, a coriander, a cumin, a garlic, a ginger, an onion and a red pepper, nor a combination of a turmeric with a garlic.   
     
     
         17 . A method for improving blood flow in peripheral blood vessels, comprising:
 administering at least one of turmeronol A, turmeronol B and bisacurone to a subject in need of improving blood flow in peripheral blood vessels; and   improving the blood flow in peripheral blood vessels in the subject.   
     
     
         18 . The method according to  claim 17 , wherein the administration comprises administering a turmeric extract extracted with at least one extraction solvent selected from water and a hydrophilic organic solvent, the turmeric extract comprising the at least one of turmeronol A, turmeronol B and bisacurone. 
     
     
         19 . The method according to  claim 17 , wherein the administration comprises administering 20 μg or more turmeronol A and turmeronol B in total to the subject per day. 
     
     
         20 . The method according to  claim 17 , wherein the administration comprises administering 17 μg or more turmeronol A to the subject per day. 
     
     
         21 . The method according to  claim 17 , wherein the administration comprises administering 5 μg or more turmeronol B to the subject per day. 
     
     
         22 . The method according to  claim 17 , wherein the administration comprises administering 80 μg or more bisacurone to the subject per day. 
     
     
         23 . The method according to  claim 17 , wherein the administration comprises administering less than 30 mg of curcumin to the subject per day. 
     
     
         24 . A method for improving blood flow in peripheral blood vessels, comprising:
 administering a turmeric to a subject in need of improving blood flow in peripheral blood vessels; and   improving the blood flow in peripheral blood vessels in the subject,   wherein the turmeric is neither a combination of a turmeric with a clove, a coriander, a cumin, a garlic, a ginger, an onion and a red pepper, nor a combination of a turmeric with a garlic.