US2021253593A1PendingUtilityA1
Substituted indole compounds

Assignee: BRISTOL MYERS SQUIBB COPriority: Nov 14, 2017Filed: Nov 13, 2018Published: Aug 19, 2021
Est. expiryNov 14, 2037(~11.3 yrs left)· nominal 20-yr term from priority
Inventors:Alaric J. Dyckman Dharmpal S. Dodd Christopher P. Mussari Trevor C. Sherwood John L. Gilmore Tasir Shamsul Haque Brian K. Whiteley David R. Tortolani Shoshana L. Posy John E. Macor Louis J. Lombardo Ramesh Kumar Sistla Anupama Kandhi Ramachandra Reddy Subramanya Hegde Laxman Pasunoori Sreekantha Ratna Kumar
A61P 29/00C07D 487/04C07D 413/14C07D 513/04C07D 498/04C07D 417/14C07D 405/14C07D 491/107C07D 471/04C07D 495/04C07D 491/08C07D 473/00C07D 409/14C07D 401/14A61K 31/4545
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Claims
Abstract

Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R 1 , R 2 , R 3 , R 4 , R 5 , m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Claims

exact text as granted — not AI-modified
1 . A compound of Formula (I) 
       
         
           
           
               
               
           
         
         or a salt thereof, wherein: 
         Ring Het is a: 
         (i) 9-membered heterocyclic ring selected from: 
       
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         (ii) 10-membered heterocyclic ring selected from: 
       
       
         
           
           
               
               
           
         
         R 1  is H, C, —CN, C 1-4  alkyl, C 1-3  fluoroalkyl, C 1-3  hydroxyalkyl, C 1-3  hydroxy-fluoroalkyl, —CR z ═CH 2 , C 3-6  cycloalkyl, —CH 2 (C 3-6  cycloalkyl), —C(O)O(C 1-3  alkyl), or tetrahydropyranyl; 
         each R 2  is independently halo, —CN, —OH, —NO 2 , C 1-4  alkyl, C 1-2  fluoroalkyl, C 1-2  cyanoalkyl, C 1-3  hydroxyalkyl, C 1-3  aminoalkyl, —O(CH 2 ) 1-2 OH, —(CH 2 ) 0-4 O(C 1-4  alkyl), C 1-3  fluoroalkoxy, —(CH 2 ) 1-4 O(C 1-3  alkyl), —O(CH 2 ) 1-2 OC(O)(C 1-3  alkyl), —O(CH 2 ) 1-2 NR x R x , —C(O)O(C 1-3  alkyl), —C(O)NR y R y , —C(O)NR x (C 1-5  hydroxyalkyl), —C(O)NR x (C 2-6  alkoxyalkyl), —C(O)NR x (C 3-6  cycloalkyl), —NR y R y , —NR y (C 1-3  fluoroalkyl), —NR y (C 1-4  hydroxyalkyl), —NR x CH 2 (phenyl), —NR x S(O) 2 (C 3-6  cycloalkyl), —NR x C(O)(C 1-3  alkyl), —NR x (CH 2 -cyclopropyl), —S(O) 2 (C 1-3  alkyl), C 3-6  cycloalkyl, phenyl, morpholinyl, dioxothiomorpholinyl, dimethyl pyrazolyl, methylpiperidinyl, methylpiperazinyl, amino-oxadiazolyl, imidazolyl, triazolyl, or —C(O)(thiazolyl); 
         R 3  is: 
         (a) -L 1 -A; or 
         (b) H, C 1-6  alkyl, C 1-3  fluoroalkyl, C 1-3  cyanoalkyl, C 1-6  hydroxyalkyl, C 1-3  hydroxy-fluoroalkyl, —CR x R x CR x (OH)CR x ═CR x R x , —C═N(NR x R x ), —(CR x R x ) 1-4 O(C 1-3  alkyl), —(CR x R x ) 1-4 O(CR x R x ) 1-3 O(C 1-3  alkyl), —CH 2 CH(OH)CH 2 O(C 1-3  alkyl), —(CR x R x ) 1-3 S(C 1-3  alkyl), —(CH 2 ) 1-3 C(O)OC(CH 3 ) 3 , —(CR x R x ) 0-3 NR x R y , —(CR x R x ) 0-3 NR x (C 1-4  hydroxyalkyl), —CH 2 CH(OH)CH 2 NR x R y , —C(O)H, —C(O)(C 1-6  alkyl), —C(O)(C 1-4  hydroxyalkyl), —C(O)(C 1-3  fluoroalkyl), —C(O)(C 1-3  chloroalkyl), —C(O)(C 1-3  cyanoalkyl), —(CR x R x ) 0-3 C(O)OH, —C(O)(CH 2 ) 0-2 O(C 1-4  alkyl), —C(O)(CR x R x ) 0-2 O(CR x R x ) 1-2 O(C 1-3  alkyl), —C(O)(CR x R x ) 0-2 O(CR x R x ) 1-2 NR y R y , —C(O)CR x R x S(O) 2 (C 1-3  alkyl), —C(O)CR x R x NR x S(O) 2 (C 1-3  alkyl), —C(O)CR x R x OC(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-3 NR y R y , —C(O)(CR x R x ) 0-1 NR x (C 1-3  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR y (C 1-6  hydroxyalkyl), —C(O)(CR x R x ) 0-2 NR x (C 1-3  fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x (C 1-5  hydroxy-fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 1-2 O(C 1-3  hydroxyalkyl), —C(O)(CR x R x ) 0-2 NR x (CH 2 ) 1-2 NR x C(O)(C 1-2  alkyl), —C(O)(CR x R x ) 0-2 NR x ((CR x R x ) 1-2 O(C 1-2  alkyl)), —C(O)(CR x R x ) 0-2 N((CR x R x ) 1-2 O(C 1-2  alkyl)) 2 , —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 1-3 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4 NR x C(O)NR x R x , —C(O)(CR x R x ) 0-3 NR x (CH 2 ) 0-1 C(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-3 N((CH 2 ) 0-1 C(O)(C 1-3  alkyl)) 2 , —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 0-1 C(O)(C 1-3  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR x (CH 2 ) 1-2 C(O)NR y R y , —C(O)(CR x R x ) 1-3 C(O)NR y R y , —C(O)(CR x R x ) 1-3  S(O) 2 NR y R y , —C(O)(CR x R x ) 0-2 NR x (CHR y (CH 2 OH)), —(CR x R x ) 1-2 C(O)NR y R y , —CH(CN)C(O)NR y R y , —(CR x R x ) 1-2 C(O)NR y (C 1-3  fluoroalkyl), —(CR x R x ) 1-2 C(O)NR y (C 1-4  hydroxyalkyl), —(CR x R x ) 1-2 C(O)NR y (C 1-3  cyanoalkyl), —(CR x R x ) 1-2 C(O)NR x (CH 2 ) 1-2 O(C 1-3  alkyl), —(CR x R x ) 1-2 C(O)NR x CH(C 1-4  alkyl)(C 1-3  hydroxyalkyl), —(CR x R x ) 1-2 C(O)NR x CH(C 1-3  hydroxyalkyl)(C 3-6  cycloalkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 C(O)NR x R x , —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2  S(C 1-3  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2  S(O) 20 H, —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 NR x C(O)(C 1-3  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-3 NR x R x , —(CH 2 ) 1-2 C(O)N(CH 2 CH 3 )(CH 2 ) 1-3 NR x R x , —(CR x R x ) 0-3 S(O) 2 (C 1-4  alkyl), —(CH 2 ) 0-2 S(O) 2 (C 1-3  fluoroalkyl), —(CR x R x ) 0-2 S(O) 2 NR y R y , —(CR x R x ) 0-2 NR x S(O) 2 (C 1-3  alkyl), —C(O)C(O)OH, —C(O)C(O)NR y R y , or —C(O)C(O)NR y (CR x R x ) 1-2 NR y R y ; 
         L 1  is a bond, —(CR x R x ) 1-2 —, —(CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 1-2 O—, —CR x R x C(O)—, —(CR x R x ) 2 NR x (CR x R x ) 0-1 —, —CR x R x C(O)NR x (CR x R x ) 0-4 —, —C(O)(CR x R x ) 0-3 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 N(C 1-2  hydroxyalkyl)(CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 1-2 CR x (OH)—, —C(O)(CR x R x ) 1-2 C(O)NR x —, —(CR x R x ) 0-2 C(O)NR x (CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 0-2 C(O)N(C 1-2  hydroxyalkyl)(CR x R x ) 1-2 —, —C(O)(CR x R x ) 1-1 O—, —C(O)(CR x R x ) 1-2 NHS(O) 2 —, —C(O)CR x (NH 2 )CR x R x —, —C(O)C(O)(CR x R x ) 0-2 —, —C(O)NR x (CR x R x ) 1-2 —, or —S(O) 2 —; 
         A is 3-oxa-8-azabicyclo[3.2.1]octanyl, 8-oxa-3-azabicyclo[3.2.1]octanyl, 1,1-dioxidothiomorpholinyl, 1,2-dioxotetrahydro-2H-thiopyranyl, 1,4-diazepanyl, 2-azabicyclo[3.1.0]hexanyl, azabicyclo[3.2.1]octanyl,2-oxa-6-azaspiro[3.3]heptanyl, azepanyl, C 3-7  cycloalkyl, imidazo[1,2-a]pyridinyl, imidazo[1,5-a]pyridinyl, imidazolyl, isoxazolyl, morpholinyl, oxadiazolyl, oxazolyl, oxetanyl, phenyl, piperazinonyl, piperazinyl, piperidinonyl, piperidinyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolidinonyl, pyrrolidinyl, pyrrolyl, quinolinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrazolyl, thiadiazolyl, thiazolyl, or triazolyl, each substituted with zero to 4 substituents independently selected from F, Cl, —OH, —CN, C 1-6  alkyl, C 1-3  fluoroalkyl, C 1-5  hydroxyalkyl, —CH 2 NR x R x , C 1-3  alkoxy, —O(CH 2 ) 1-3 NR x R x , —O(CH 2 ) 1-3 NR x (pyridinyl), —C(O)(C 1-3  alkyl), —C(O)O(C 1-3  alkyl), —C(O)NR y R y , —NR x R x , —NR x C(O)(C 1-3  alkyl), —O(pyrimidinyl), C 3-6  cycloalkyl, morpholinyl, phenyl, methyl piperazinyl, pyridinyl, and pyrrolidinyl; 
         each R x  is independently H or —CH 3 ; 
         each R y  is independently H or C 1-6  alkyl; 
         each R 4  is independently F, —OH, C 1-2  alkyl, or —OCH 3 ; or two R 4  attached to the same carbon atom form ═O; or wherein when m is at least 2, two R 4 , each attached to a different carbon atom adjacent to the nitrogen atom in the piperidinyl ring, can form a —CH 2 CH 2 — bridge; 
         each R 5  is independently F, Cl, —CN, C 1-2  alkyl, C 1-2  fluoroalkyl, or —OCH 3 ; 
         m is zero, 1, 2, 3, or 4; 
         n is zero, 1, or 2; and 
         p is zero, 1, 2, 3, or 4. 
       
     
     
         2 . The compound according to  claim 1  or a salt thereof, wherein:
 R 1  is H, Cl, —CN, C 1-4  alkyl, C 1-2  fluoroalkyl, C 1-2  hydroxyalkyl, or —C(O)O(C 1-2  alkyl); 
 each R 2  is independently F, Cl, —CN, —OH, C 1-4  alkyl, C 1-2  fluoroalkyl, C 1-2  cyanoalkyl, C 1-3  hydroxyalkyl, C 1-3  aminoalkyl, C 1-4  alkoxy, —NR y R y , —C(O)NR y R y , —C(O)NR x (C 1-4  hydroxyalkyl), —C(O)NR x (C 2-4  alkoxyalkyl), —C(O)NR x (C 3-6  cycloalkyl), —S(O) 2 (C 1-3  alkyl), C 3-6  cycloalkyl, morpholinyl, phenyl, or dimethyl pyrazolyl; 
 R 3  is: 
 (a) -L 1 -A; or 
 (b) H, C 1-6  alkyl, C 1-3  fluoroalkyl, C 1-3  cyanoalkyl, C 1-5  hydroxyalkyl, —(CR x R x ) 1-2 O(C 1-2  alkyl), —(CR x R x ) 1-4 O(CR x R x ) 1-3 O(C 1-3  alkyl), —CH 2 CH(OH)CH 2 O(C 1-3  alkyl), —(CR x R x ) 1-3 S(C 1-3  alkyl), —(CH 2 ) 1-3 C(O)OC(CH 3 ) 3 , —(CR x R x ) 0-3 NR x R y , —(CR x R x ) 0-3 NR x (C 1-4  hydroxyalkyl), —CH 2 CH(OH)CH 2 NR x R y , —C(O)(C 1-6  alkyl), —C(O)(C 1-4  hydroxyalkyl), —C(O)(C 1-3  fluoroalkyl), —C(O)(C 1-3  chloroalkyl), —C(O)(C 1-3  cyanoalkyl), —(CR x R x ) 0-3 C(O)OH, —C(O)(CH 2 ) 0-2 O(C 1-4  alkyl), —C(O)(CR x R x ) 0-2 O(CR x R x ) 1-2 O(C 1-3  alkyl), —C(O)(CH 2 ) 0-2 O(CH 2 ) 1-2 NR y R y , —C(O)CR x R x S(O) 2 (C 1-2  alkyl), —C(O)CR x R x NR x S(O) 2 (C 1-2  alkyl), —C(O)CR x R x OC(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-2 NR y R y , —C(O)(CR x R x ) 0-2 NR x (C 1-2  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR y (C 1-6  hydroxyalkyl), —C(O)(CR x R x ) 0-2 NR x (C 1-3  fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x (C 1-5  hydroxy-fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x ((CR x R x ) 1-2 O(C 1-2  alkyl)), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 1-2 O(C 1-3  hydroxyalkyl), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 1-2 NR x C(O)(C 1-2  alkyl), —C(O)(CR x R x ) 0-2 NR x ((CR x R x ) 1-2 O(C 1-2  alkyl)), —C(O)(CR x R x ) 0-1 NR x (CR x R x ) 1-3 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4NR x C(O)NR x R x , —C(O)(CR x R x ) 0-3 NR x (CH 2 ) 0-1 C(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 0-1 C(O)(C 1-3  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR x (CH 2 ) 1-2 C(O)NR y R y , —C(O)(CR x R x ) 0-2 NR x (CHR y (CH 2 OH)), —(CR x R x ) 1-2 C(O)NR y R y , —(CR x R x ) 1-2 C(O)NR y (C 1-3  fluoroalkyl), —(CR x R x ) 1-2 C(O)NR y (C 1-4  hydroxyalkyl), —(CR x R x ) 1-2 C(O)NR x (C 1-3  cyanoalkyl), —CH(CN)C(O)NR y R y , —(CR x R x ) 1-2 C(O)NR x (CH 2 ) 1-2 O(C 1-3  alkyl), —(CR x R x ) 1-2 C(O)NR x CH(C 1-4  alkyl)(C 1-3  hydroxyalkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 C(O)NR x R x , —(CH 2 ) 1-2 S(O) 2 NR x (CH 2 ) 1-2 S(C 1-2  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2  S(O) 20 H, —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2NR x C(O)(C 1-3  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-3 NR x R x , —(CH 2 ) 1-2 C(O)N(CH 2 CH 3 )(CH 2 ) 1-3 NR x R x , —(CR x R x ) 1-3 S(O) 2 (C 1-4  alkyl), —(CH 2 ) 0-2 S(O) 2 (C 1-3  fluoroalkyl), —(CH 2 ) 1-2 S(O) 2 NR y R y , —C(O)C(O)OH, —C(O)C(O)NR y R y , or —C(O)C(O)NR y (CR x R x ) 1-2 NR y R y ; 
 L 1  is a bond, —(CR x R x ) 1-2 —, —(CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 1-2 O—, —CR x R x C(O)—, —(CR x R x ) 2 NR x (CR x R x ) 0-1 —, —CR x R x C(O)NR x (CR x R x ) 0-4 —, —C(O)(CR x R x ) 0-3 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 N(C 1-2  hydroxyalkyl)(CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 1-2 CR x (OH)—, —C(O)(CR x R x ) 1-2 C(O)NR x —, —(CR x R x ) 0-2 C(O)NR x (CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 0-2 C(O)N(C 1-2  hydroxyalkyl)(CR x R x ) 1-2 —, —C(O)(CR x R x ) 0-1 O—, —C(O)(CR x R x ) 1-2 NHS(O) 2 —, —C(O)CR x (NH 2 )CR x R x —, —C(O)C(O)(CR x R x ) 0-2 —, —C(O)NR x (CR x R x ) 1-2 —, or —S(O) 2 —; 
 each R 5  is independently F, Cl, —CN, C 1-2  alkyl, or —OCH 3 ; 
 m is zero, 1, or 2; 
 n is zero or 1; and 
 p is zero, 1, or 2. 
 
     
     
         3 . The compound according to  claim 1  or a salt thereof, wherein:
 R 1  is —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 OH, —CH 2 CHF 2 , or —C(O)OCH 3 ; 
 each R 2  is independently F, Cl, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 CH(CH 3 ) 2 , —CF 3 , —CH 2 OH, —C(CH 3 ) 2 OH, —OCH 3 , —OCH 2 CH 3 , —NH 2 , —NH(CH 3 ), —C(O)NH 2 , —C(O)NH(CH 3 ), —C(O)N(CH 3 ) 2 , —C(O)NH(CH 2 CH 2 OH), —C(O)NH(CH 2 CH 2 OCH 3 ), —C(O)NH(CH 2 C(CH 3 ) 2 OH), —C(O)NH(cyclopropyl), —C(O)N(CH 3 )(CH 2 CH 3 ), —C(O)N(CH 3 )(CH 2 CH 2 OH), —S(O) 2 CH 3 , phenyl, or dimethyl pyrazolyl; 
 R 3  is: 
 (a) -L 1 -A; or 
 (b) H, —CH 3 , —CH(CH 3 ) 2 , —CH 2 CH 2 CH 3 , —CH 2 CH(CH 3 ) 2 , —CH 2 CH 2 CF 3 , —CH 2 CH 2 CH 2 CF 3 , —CH 2 CN, —CH 2 CH 2 CN, —CH 2 C(CH 3 ) 2 OH, —CH(CH 2 OH) 2 , —CH 2 CH 2 OCH 3 , —CH(CH 2 OH)(CH 2 OCH 3 ), —CH 2 CH 2 NH 2 , —CH 2 CH 2 NH(CH 3 ), —CH 2 CH 2 N(CH 2 CH 3 ) 2 , —CH 2 CH 2 CH 2 N(CH 3 ) 2 , —CH 2 CH(CH 3 )CH 2 N(CH 3 ) 2 , —CH 2 C(CH 3 ) 2 CH 2 N(CH 3 ) 2 , —CH 2 CH 2 NH(S(O) 2 CH 3 , —CH 2 CH 2 S(O) 2 CH 3 , —CH 2 CH 2 CH 2 S(O) 2 CH 3 , —CH 2 CH 2 S(O) 2 NH 2 , —CH 2 C(O)NH 2 , —CH 2 C(O)NH(CH 3 ), —CH 2 C(O)N(CH 3 ) 2 , —CH 2 C(O)NH(CF 3 ), —C(O)CH 2 CH(CH 3 )OH, —C(O)CH 2 C(CH 3 ) 2 OH, —C(O)CH 2 NH 2 , —C(O)CH 2 NH(CH 3 ), —C(O)CH 2 NH(CH(CH 3 ) 2 ), —C(O)CH 2 N(CH 3 ) 2 , —C(O)CH 2 N(CH 3 )(CH(CH 3 ) 2 ), —C(O)CH 2 NH(CH 2 C(CH 3 ) 3 ), —C(O)CH 2 NH(CH(CH 3 )CH 2 CH 3 ), —C(O)CH 2 NH(CH 2 CH 2 CH 2 N(CH 3 ) 2 ), —C(O)CH 2 N(CH 3 )(CH 2 CH(CH 3 ) 2 ), —C(O)CH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 2 CH 2 N(CH 3 )(CH 2 CH 3 ), —C(O)CH 2 CH 2 N(CH 3 )(CH(CH 3 ) 2 ), —C(O)CH 2 CH(CH 3 )NH 2 , —C(O)CH 2 NHC(O)CH 3 , —C(O)CH 2 CH 2 C(O)N(CH 3 ) 2 , —C(O)CH 2 NH(CH 2 CH 2 NHC(O)CH 3 ), —C(O)CH 2 S(O) 2 CH 3 , —S(O) 2 CH 2 CH 2 OH, or —S(O) 2 CH 2 CH 2 N(CH 3 ) 2 ; 
 L 1  is a bond, —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, —CH 2 C(O)—, —C(O)—, —C(O)CH 2 —, —C(O)CH 2 CH 2 —, —C(O)CH 2 NH—, —C(O)CH 2 N(CH 3 )—, —C(O)CH 2 CH 2 N(CH 3 )—, or —C(O)CH 2 NHCH 2 C(CH 3 ) 2 —; 
 A is (1R,5S)-3-oxa-8-azabicyclo[3.2.1]octanyl, (1R,5S)-8-oxa-3-azabicyclo[3.2.1]octanyl, 1,1-dioxidothiomorpholinyl, 1,2-dioxotetrahydro-2H-thiopyranyl, 1,4-diazepanyl, 2-azabicyclo[3.1.0]hexanyl, azabicyclo[3.2.1]octanyl,2-oxa-6-azaspiro[3.3]heptanyl, azepanyl, cyclohexyl, cyclopropyl, imidazo[1,2-a]pyridinyl, imidazo[1,5-a]pyridinyl, imidazolyl, isoxazolyl, morpholinyl, oxadiazolyl, oxazolyl, oxetanyl, phenyl, piperazinonyl, piperazinyl, piperidinonyl, piperidinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrrolidinonyl, pyrrolidinyl, quinolinyl, tetrahydropyranyl, thiadiazolyl, thiazolyl, or triazolyl, each substituted with zero to 4 substituents independently selected from F, Cl, —OH, —CH 3 , —CH 2 H3, —CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 CH 3 , —CH 2 CH(CH 3 ) 2 , —CH 2 OH, —CH 2 N(CH 3 ) 2 , —OCH 3 , —OCH 2 CH 2 CH 2 N(CH 3 ) 2 , —OCH 2 CH 2 N(CH 3 )(pyridinyl), —C(O)CH 3 , —C(O)OCH 3 , —C(O)OCH 2 CH 3 , —C(O)NH 2 , —C(O)N(CH 2 CH 3 ) 2 , —NH 2 , —N(CH 3 ) 2 , —NHC(O)CH 3 , —O(pyrimidinyl), morpholinyl, phenyl, methyl piperazinyl, pyridinyl, and pyrrolidinyl; 
 each R 4  is independently F or —OH, or two R 4  attached to the same carbon atom form ═O; 
 each R 5  is independently F, Cl, —CH 3 , —CF 3 , or —OCH 3 ; 
 m is zero, 1, or 2; 
 n is zero, 1, or 2; and 
 p is zero, 1, 2, or 3. 
 
     
     
         4 . The compound according to  claim 1  or a salt thereof, wherein Ring Het is said 9-membered heterocyclic ring. 
     
     
         5 . The compound according to  claim 1  or a salt thereof, wherein Ring Het is said 10-membered heterocyclic ring. 
     
     
         6 . The compound according to  claim 1  or a salt thereof, wherein:
 R 3  is -L 1 -A; and 
 L 1  is a bond, —(CR x R x ) 1-2 —, —(CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 0-2 O—, —CR x R x C(O)—, —(CR x R x ) 2 NR x (CR x R x ) 0-1 —, —CR x R x C(O)NR x (CR x R x ) 0-4 —, —C(O)(CR x R x ) 0-3 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 N(C 1-2  hydroxyalkyl)(CR x R x ) 0-2 —, —C(O)(CR x R x ) 0-2 NR x (CR x R x ) 0-2 CR x (OH)—, —C(O)(CR x R x ) 1-2 C(O)NR x —, —(CR x R x ) 0-2 C(O)NR x (CR x R x ) 1-2 CR x (OH)—, —(CR x R x ) 0-2 C(O)N(C 1-2  hydroxyalkyl)(CR x R x ) 1-2 —, —C(O)(CR x R x ) 0-1 O—, —C(O)(CR x R x ) 1-2 NHS(O) 2 —, —C(O)CR x (NH 2 )CR x R x —, —C(O)C(O)(CR x R x ) 0-2 —, —C(O)NR x (CR x R x ) 1-2 —, or —S(O) 2 —. 
 
     
     
         7 . The compound according to  claim 6  or a salt thereof, wherein A is azepanyl, cyclohexyl, cyclopropyl, imidazo[1,2-a]pyridinyl, imidazo[1,5-a]pyridinyl, imidazolyl, isoxazolyl, morpholinyl, oxadiazolyl, oxazolyl, oxetanyl, phenyl, piperazinonyl, piperazinyl, piperidinonyl, piperidinyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrrolidinonyl, pyrrolidinyl, quinolinyl, tetrahydropyranyl, thiadiazolyl, thiazolyl, or triazolyl, each substituted with zero to 4 substituents independently selected from F, Cl, —OH, —CH 3 , —CH 2 H3, —CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 CH 3 , —CH 2 CH(CH 3 ) 2 , —CH 2 OH, —CH 2 N(CH 3 ) 2 , —OCH 3 , —OCH 2 CH 2 CH 2 N(CH 3 ) 2 , —OCH 2 CH 2 N(CH 3 )(pyridinyl), —C(O)CH 3 , —C(O)OCH 3 , —C(O)OCH 2 CH 3 , —C(O)NH 2 , —C(O)N(CH 2 CH 3 ) 2 , —NH 2 , —N(CH 3 ) 2 , —NHC(O)CH 3 , —O(pyrimidinyl), morpholinyl, phenyl, methyl piperazinyl, pyridinyl, and pyrrolidinyl. 
     
     
         8 . The compound according to  claim 1  or a salt thereof, wherein R 3  is H, C 1-6  alkyl, C 1-3  fluoroalkyl, C 1-3  cyanoalkyl, C 1-5  hydroxyalkyl, —(CR x R x ) 1-2 O(C 1-2  alkyl), —(CR x R x ) 1-4 O(CR x R x ) 1-3 O(C 1-3  alkyl), —CH 2 CH(OH)CH 2 O(C 1-3  alkyl), —(CR x R x ) 1-3 S(C 1-3  alkyl), —(CH 2 ) 1-3 C(O)OC(CH 3 ) 3 , —(CR x R x ) 0-3 NR x R y , —(CR x R x ) 0-3 NR x (C 1-4  hydroxyalkyl), —CH 2 CH(OH)CH 2 NR x R y , —C(O)(C 1-6  alkyl), —C(O)(C 1-4  hydroxyalkyl), —C(O)(C 1-3  fluoroalkyl), —C(O)(C 1-3  chloroalkyl), —C(O)(C 1-3  cyanoalkyl), —(CR x R x ) 0-3 C(O)OH, —C(O)(CH 2 ) 0-2 O(C 1-4  alkyl), —C(O)(CR x R x ) 0-2 O(CR x R x ) 1-2 O(C 1-3  alkyl), —C(O)(CH 2 ) 0-2 O(CH 2 ) 1-2 NR y R y , —C(O)CR x R x S(O) 2 (C 1-2  alkyl), —C(O)CR x R x NR x S(O) 2 (C 1-2  alkyl), —C(O)CR x R x OC(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-2 NR y R y , —C(O)(CR x R x ) 0-2 NR x (C 1-2  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR y (C 1-6  hydroxyalkyl), —C(O)(CR x R x ) 0-2 NR x (C 1-3  fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x (C 1-5  hydroxy-fluoroalkyl), —C(O)(CR x R x ) 0-1 NR x ((CR x R x ) 1-2 O(C 1-2  alkyl)), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 1-2 O(C 1-3  hydroxyalkyl), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 1-2 NR x C(O)(C 1-2  alkyl), —C(O)(CR x R x ) 0-2 NR x ((CR x R x ) 1-2 O(C 1-2  alkyl)), —C(O)(CR x R x ) 0-1 NR x (CR x R x ) 1-3 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4 NR x R x , —C(O)CR x (NH 2 )(CR x R x ) 1-4 NR x C(O)NR x R x , —C(O)(CR x R x ) 0-3 NR x (CH 2 ) 0-1 C(O)(C 1-3  alkyl), —C(O)(CR x R x ) 0-1 NR x (CH 2 ) 0-1 C(O)(C 1-3  cyanoalkyl), —C(O)(CR x R x ) 0-2 NR x (CH 2 ) 1-2 C(O)NR y R y , —C(O)(CR x R x ) 0-2 NR x (CHR y (CH 2 OH)), —(CR x R x ) 1-2 C(O)NR y R y , —(CR x R x ) 1-2 C(O)NR y (C 1-3  fluoroalkyl), —(CR x R x ) 1-2 C(O)NR y (C 1-4  hydroxyalkyl), —(CR x R x ) 1-2 C(O)NR x (C 1-3  cyanoalkyl), —CH(CN)C(O)NR y R y , —(CR x R x ) 1-2 C(O)NR x (CH 2 ) 1-2 O(C 1-3  alkyl), —(CR x R x ) 1-2 C(O)NR x CH(C 1-4  alkyl)(C 1-3  hydroxyalkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 C(O)NR x R x , —(CH 2 ) 1-2 S(O) 2 NR x (CH 2 ) 1-2 S(C 1-2  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 S(O) 20 H, —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-2 NR x C(O)(C 1-3  alkyl), —(CH 2 ) 1-2 C(O)NR x (CH 2 ) 1-3 NR x R x , —(CH 2 ) 1-2 C(O)N(CH 2 CH 3 )(CH 2 ) 1-3 NR x R x , —(CR x R x ) 1-3 S(O) 2 (C 1-4  alkyl), —(CH 2 ) 0-2 S(O) 2 (C 1-3  fluoroalkyl), —(CH 2 ) 1-2 S(O) 2 NR y R y , —C(O)C(O)OH, —C(O)C(O)NR y R y , or —C(O)C(O)NR y (CR x R x ) 1-2 NR y R y . 
     
     
         9 . (canceled) 
     
     
         10 . A pharmaceutical composition comprising a compound according to  claim 1  or a pharmaceutically-acceptable salt thereof;
 and a pharmaceutically acceptable carrier. 
 
     
     
         11 . (canceled) 
     
     
         12 . (canceled) 
     
     
         13 . A method of treating an autoimmune disease or a chronic inflammatory disease, comprising administering to a mammalian patent a compound according to  claim 1  or a pharmaceutically acceptable salt thereof, wherein said autoimmune disease or chronic inflammatory disease is selected from systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis (MS), and Sjögren&#39;s syndrome. 
     
     
         14 . The compound according to  claim 1  or a salt thereof, wherein said compound is selected from:
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (1); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (2); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1h-indol-2-yl)-1-(methylsulfonyl)-1h-pyrrolo[2,3-b]pyridine (3); 
 3-methyl-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (4); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]isoxazol-3-ol (5); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylbenzo[d]oxazole (6); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]isoxazol-3-amine (7); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-9H-purin-6-amine (8); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]thiazole (9); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]oxazol-2(3H)-one (10); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]oxazol-2(3H)-one (11); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]thiazole (12); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (13); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[3,2-c]pyridine (14); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-c]pyridine (15); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)oxazolo[4,5-b]pyridin-2(3H)-one (16); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (17); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (18); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[3,2-b]pyridine (19); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)furo[3,2-b]pyridine (20); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (21); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,5-naphthyridine (22); 
 7-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[3,2-b]pyridine (23); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-b]pyridazin-2-amine (24); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methoxyimidazo[1,2-a]pyrazine (25); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine (26); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-b]pyridazine (27); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrazine (28); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrimidine (29); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methyl-[1,2,4]triazolo[1,5-b]pyridazine (30); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,4]triazolo[1,5-b]pyridazine (31); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazine (32); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazine (33); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyrazin-8-ol (34); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridine (35); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-4-methyl-1H-pyrrolo[2,3-b]pyridine (36); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,2-dimethyl-1H-pyrrolo[2,3-b]pyridine (37); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (38); 
 3-chloro-4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (39); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,5-dimethyl-1H-pyrrolo[3,2-b]pyridine (40); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrazolo[4,3-b]pyridine (41); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrazolo[4,3-b]pyridine (42); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrazolo[4,3-b]pyridine (43); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-3H-imidazo[4,5-b]pyridine (44); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-3H-imidazo[4,5-b]pyridine (45); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-1H-pyrazolo[3,4-b]pyridine (46); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyrazine (47); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (48); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-1H-pyrazolo[4,3-b]pyridine (49); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-benzo[d]imidazole (50); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-benzo[d][1,2,3]triazole (51); 
 5-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-benzo[d][1,2,3]triazole (52); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (53); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine (54); 
 7-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine (55); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-[1,2,3]triazolo[4,5-b]pyridine (56); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (57); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)oxazolo[4,5-b]pyridin-2(3H)-one (58); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridine (59); 
 7-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridine (60); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridine (61); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine (62); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine (63); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrimidine (64); 
 3-isopropyl-5-(piperidin-4-yl)-1H, 1′H-2,6′-biindole (65); 
 3-isopropyl-5-(piperidin-4-yl)-1H, 1′H-2,5′-biindole (66); 
 2-(benzofuran-5-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole (67); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (68); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one (69); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (70); 
 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)tetrazolo[1,5-a]pyridin-8-yl) methanol (71); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyltetrazolo[1,5-a]piperidin (72); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyltetrazlo[1,5-a]pyridine (73); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5,8-dimethyltetrazolo[1,5-a]pyridine (74); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazlo[1,5-a]pyridine (75); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazlo[1,5-a]pyridine (76); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (77); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,3]triazolo[1,5-a]pyridine (78); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (79); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) tetrazolo[1,5-a]pyridine (80); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (81); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)tetrazolo[1,5-a]pyridine (82); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine (83); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazol-3-amine (84); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazol-3-ol (85); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]isoxazol-3-amine (86); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoxalin-2-ol (87); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methylquinoxaline (88); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one (89); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3,7-dimethylbenzo[d]oxazol-2(3H)-one (90); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylbenzo[d]oxazol-2(3H)-one (91); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,7-dimethylbenzo[d]oxazole (92); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazol-3-amine (93); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,4-dimethyl-1H-indazole (94); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]isoxazol-3-amine (95); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridine (96); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrazolo[3,4-c]pyridine (97); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methyl-2H-pyrazolo[3,4-c]pyridine (98); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-amine (99); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-indazole (100); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylthiazolo[5,4-b]pyridine (101); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-b]pyridazine-3-carbonitrile (102); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methylimidazo[1,2-b]pyridazine (103); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylquinoline (104); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methoxyquinoline (105); 
 7-chloro-4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazole (106); 
 4-hydroxy-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoline-3-carbonitrile (107); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-b]pyridazine (108); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) quinoline-8-carbonitrile (109); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (110); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,2-a]pyridine (111); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine (112); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (113); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methylimidazo[1,2-a]pyridine (114); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (115); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-a]pyridin-2-amine (116); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-a]pyridin-8-amine (117); 
 8-fluoro-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (118); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine-3-carbonitrile (119); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,8-dimethylimidazo[1,2-a]pyridine (120); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3,8-dimethylimidazo[1,2-a]pyridine (121); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,7-dimethylimidazo[1,2-a]pyridine (122); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,5-dimethylimidazo[1,2-a]pyridine (123); 
 (6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-a]pyridin-8-yl) methanol (124); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methoxyimidazo[1,2-a]pyridine (125); 
 8-fluoro-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (126); 
 7-chloro-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (127); 
 7-chloro-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (128); 
 6-(3-(2,2-difluoroethyl)-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (129); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine-3-carbonitrile (130); 
 6-(3-(2,2-difluoroethyl)-5-(piperidin-4-yl)-1H-indol-2-yl)-8-fluoroimidazo[1,2-a]pyridine (131); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,3,8-trimethylimidazo[1,2-a]pyridine (132); 
 8-chloro-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (133); 
 2-(6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridin-8-yl) propan-2-ol (134); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine (135); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine (136); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methyl-8-(trifluoromethyl) imidazo[1,2-a]pyridine (137); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,7-dimethyl-2H-indazole (138); 
 8-chloro-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)quinoline (139); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylquinoline (140); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoline (141); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,7-dimethylpyrazolo[1,5-a]pyridine (142); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylpyrazolo[1,5-a]pyridine (143); 
 7-isobutyl-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyridine (144); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazo[1,5-a]pyridine (145); 
 3-fluoro-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyridine (146); 
 6-fluoro-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (147); 
 6-fluoro-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyrimidine (148); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazlo[1,5-a]pyrimidine (149); 
 3-fluoro-5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyrimidine (150); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyridine (151); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridine (152); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (153); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridine (154); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (155); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (156); 
 5-ethoxy-7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (157); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridine (158); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyrimidine (159); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-2,5-dimethylimidazo[1,2-a]pyridine (160); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,2-a]pyridine (161); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-2-methylimidazo[1,2-a]pyridine (162); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methoxyimidazo[1,2-a]pyridine (163); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,5-a]pyridine (164); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)quinoxaline (165); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (166); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]oxazol-2(3H)-one (167); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)benzo[d]oxazol-2(3H)-one (168); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazole (169); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine (170); 
 4-(5-(3-fluoropiperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (171); 
 4-(5-(3-fluoropiperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (172); 
 4-(3-ethyl-5-(3-fluoropiperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (173); 
 methyl 5-(piperidin-4-yl)-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indole-3-carboxylate (174); 
 4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-3-ol (175); 
 (5-(piperidin-4-yl)-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-3-yl)methanol (176); 
 4-(3-ethyl-5-(3-fluoropiperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (177); 
 4-(3-(2,2-difluoroethyl)-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (178); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-c]pyridine (179); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (180); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (181); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazole (182); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,5-a]pyridine (183); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (184); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (185); 
 2-(benzofuran-2-yl)-3-ethyl-5-(piperidin-4-yl)-1H-indole (186); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-b]pyridazine (187); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (188); 
 7-(3-(2,2-difluoroethyl)-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (189); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)quinoline (190); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)pyrrolo[2,1-f][1,2,4]triazine (191); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyridine (192); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (193); 
 3-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrazine (194); 
 2-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyrazine (195); 
 8-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (196); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (197); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (198); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-3 (2H)-one (199); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrimidine (200); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyrazine (201); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (202); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (203); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine (204); 
 4-(3-(2,2-difluoroethyl)-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (205); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (206); 
 2-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine (207); 
 2-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (208); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)thiazolo[5,4-b]pyridine (209); 
 N-methyl-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-amine (210); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-amine (211); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-ol (212); 
 3-methoxy-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (213); 
 3-isopropyl-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (214); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine (215); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-ol (216); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrrolo[2,3-b]pyridine (217); 
 3-methyl-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (218); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-ethyl-1H-pyrrolo[2,3-b]pyridine (219); 
 3-ethyl-4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (220); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-isopropyl-1H-pyrrolo[2,3-b]pyridine (221); 
 3-ethyl-4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (222); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-phenyl-1H-pyrrolo[2,3-b]pyridine (223); 
 3-ethyl-4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (224); 
 3-(1,3-dimethyl-1H-pyrazol-5-yl)-4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (225); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (226); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (227); 
 7-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridin-5-amine (228); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (229); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (230); 
 4-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (231); 
 2-methyl-7-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridine (232); 
 7-(3-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-3H-[1,2,3]triazolo[4,5-b]pyridine (233); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-4-methylbenzo[d]oxazole (234); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-indazole-7-carbonitrile (235); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (236); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one (237); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine (238); 
 7-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)isoxazolo[4,5-b]pyridin-3-amine (239); 
 6-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine (240); 
 5-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (241); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-b]pyridazine (242); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (243); 
 3-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (244); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7H-pyrrolo[2,3-c]pyridazine (245); 
 4-(3-ethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-1H-pyrrolo[2,3-b]pyridine (246); 
 4-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-5-methyl-1H-pyrrolo[2,3-b]pyridine (247); 
 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-2-one (248); 
 4-(3-isopropyl-5-(piperidin-4-yl)-6-(trifluoromethyl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (249); 
 4-(3-isopropyl-6-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (250); 
 4-(3-ethyl-7-fluoro-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (251); 
 4-(6-chloro-3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (252); 
 4-(6-fluoro-3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (253); 
 4-(3-ethyl-4-methyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (254); 
 4-(3-isopropyl-6-methoxy-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (255); 
 4-(3,4-dimethyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (256); 
 6-(3-ethyl-4,6-difluoro-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (257); 
 6-(4-fluoro-3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (258); 
 4-(4-fluoro-3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (259); 
 8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (260); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine-3-carboxamide (261); 
 N-cyclopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine-2-carboxamide (262); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-N,N-dimethylimidazo[1,2-a]pyridine-2-carboxamide (263); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (264); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N,N, 8-trimethylimidazo[1,2-a]pyridine-2-carboxamide (265); 
 N-ethyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (266); 
 N-(2-hydroxyethyl)-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine-2-carboxamide (267); 
 N-(2-hydroxyethyl)-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (268); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N-(2-methoxyethyl)-8-methylimidazo[1,2-a]pyridine-2-carboxamide (269); 
 N-(2-hydroxy-2-methylpropyl)-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine-2-carboxamide (270); 
 6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethylimidazo[1,2-a]pyridine (271); 
 8-ethyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (272); 
 8-isopropyl-6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (273); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N,7-dimethylpyrazolo[1,5-a]pyridine-3-carboxamide (274); 
 5-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-N,N,7-trimethylpyrazolo[1,5-a]pyridine-3-carboxamide (275); 
 2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (276); 
 2-(4-(2-([1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (277); 
 2-(4-(2-([1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (278); 
 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (279); 
 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (280); 
 2-(4-(3-isopropyl-2-(8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (281); 
 2-(4-(3-isopropyl-2-(8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (282); 
 2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (283); 
 2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl) piperidin-1-yl) acetamide (284); 
 2-(4-(2-(1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (285); 
 2-(4-(2-(1,2-dimethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (286); 
 2-(4-(3-isopropyl-2-(4-methyl-1H-benzo[d]imidazol-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (287); 
 2-(4-(2-(benzo[d]oxazol-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (288); 
 2-(4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) acetamide (289); 
 2-(4-(2-(imidazo[1,2-a]pyrimidin-3-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (290); 
 2-(4-(3-isopropyl-2-(4-methylbenzo[d]oxazol-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (291); 
 2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (292); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (293); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)-1-morpholinoethan-1-one (294); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (295); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)acetamide (296); 
 2-(4-(2-(1,6-dimethyl-7-oxo-6,7-dihydro-H-pyrrolo[2,3-c]pyridin-3-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (297); 
 2-(4-(2-(benzo[d]thiazol-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (298); 
 2-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (299); 
 2-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (300); 
 2-(4-(3-isopropyl-2-(tetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (301); 
 2-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (302); 
 2-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (303); 
 2-(4-(3-isopropyl-2-(tetrazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (304); 
 2-(4-(2-([1,2,4]triazolo[4,3-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (305); 
 2-(4-(2-([1,2,4]triazolo[4,3-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1l-yl)-N-methylacetamide (306); 
 2-(4-(3-isopropyl-2-(4-methyl-[1,2,3]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (307); 
 2-(4-(3-isopropyl-2-(5-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (308); 
 2-(4-(2-(7,8-dimethyltetrazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (309); 
 2-(4-(2-(5,8-dimethyltetrazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (310); 
 2-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetamide (311); 
 2-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (312); 
 2-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (313); 
 2-(4-(3-isopropyl-2-(7-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (314); 
 2-(4-(3-isopropyl-2-(7-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetamide (315); 
 2-(4-(3-isopropyl-2-(7-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (316); 
 2-(4-(3-isopropyl-2-(3-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)acetamide (317); 
 2-(4-(3-isopropyl-2-(3-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (318); 
 2-(4-(3-isopropyl-2-(3-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (319); 
 2-(4-(3-isopropyl-2-(7-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (320); 
 2-(4-(3-isopropyl-2-(7-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)acetamide (321); 
 2-(4-(3-isopropyl-2-(2-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (322); 
 2-(4-(3-isopropyl-2-(2-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (323); 
 2-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (324); 
 2-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (325); 
 2-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (326); 
 2-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (327); 
 2-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (328); 
 2-(4-(2-(8-(hydroxymethyl)imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (329); 
 6-(5-(1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-N-methylimidazo[1,2-a]pyridine-2-carboxamide (330); 
 2-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (331); 
 2-(4-(3-isopropyl-2-(5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (332); 
 2-(4-(3-isopropyl-2-(5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (333); 
 2-(4-(3-isopropyl-2-(5-methoxy-2-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (334); 
 2-(4-(3-isopropyl-2-(5-methoxy-2-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (335); 
 2-(4-(2-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (336); 
 2-(4-(3-isopropyl-2-(7-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (337); 
 2-(4-(2-(2,7-dimethylbenzo[d]oxazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (338); 
 2-(4-(2-(2,7-dimethylbenzo[d]oxazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (339); 
 2-(4-(3-isopropyl-2-(2-methoxyquinolin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (340); 
 2-(4-(2-(8-(hydroxymethyl)-6-imidazo[1,2-a]pyridinyl-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (341); 
 2-(4-(2-(8-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (342); 
 2-(4-(2-(8-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (343); 
 6-(5-(1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-N-(2-hydroxyethyl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (344); 
 N-(2-hydroxyethyl)-6-(3-isopropyl-5-(1-(2-(methylamino)-2-oxoethyl)piperidin-4-yl)-1H-indol-2-yl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (345); 
 6-(5-(1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-N,8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (346); 
 2-(4-(3-isopropyl-2-(5-methoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (347); 
 2-(4-(3-isopropyl-2-(5-methoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (348); 
 2-(4-(2-(5-ethoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (349); 
 2-(4-(2-(5-ethoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (350); 
 2-(4-(2-(5-ethoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (351); 
 2-(4-(2-(2,5-dimethylimidazo[1,2-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (352); 
 2-(4-(2-(2,5-dimethylimidazo[1,2-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (353); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (354); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (355); 
 2-(4-(3-isopropyl-2-(5-methoxyimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (356); 
 2-(4-(3-isopropyl-2-(5-methoxyimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (357); 
 2-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (359); 
 2-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (360); 
 2-(4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (361); 
 2-(4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (362); 
 2-(4-(2-(imidazo[1,2-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (363); 
 2-(4-(2-(1,7-dimethyl-H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (364); 
 2-(4-(2-(1,4-dimethyl-1H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (365); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (366); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (367); 
 2-(4-(3-isopropyl-2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (368); 
 2-(4-(2-(8-cyanoquinolin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)acetamide (369); 
 2-(4-(2-(8-cyanoquinolin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (370); 
 2-(4-(2-(8-cyanoquinolin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (371); 
 2-(4-(3-isopropyl-2-(8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (372); 
 2-(4-(3-isopropyl-2-(8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (373); 
 2-(4-(2-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (374); 
 2-(4-(2-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (375); 
 2-(4-(3-isopropyl-2-(2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (376); 
 2-(4-(3-isopropyl-2-(2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (377); 
 2-(4-(2-(2,7-dimethyl-2H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (378); 
 2-(4-(2-(2,7-dimethyl-2H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (379); 
 2-(4-(2-(8-chloroquinolin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (380); 
 2-(4-(2-(8-chloroquinolin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (381); 
 2-(4-(2-(1,4-dimethyl-1H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (382); 
 2-(4-(2-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (383); 
 2-(4-(2-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (384); 
 2-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (385); 
 2-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (386); 
 2-(4-(3-(2,2-difluoroethyl)-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (387); 
 2-(4-(3-ethyl-2-(1H-indazol-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (388); 
 2-(4-(3-ethyl-2-(1H-indazol-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (389); 
 2-(4-(2-(3-cyanoimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (390); 
 2-(4-(2-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (391); 
 2-(4-(2-(7-isobutyl-2-methylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (392); 
 2-(4-(2-(7-isobutyl-2-methylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (393); 
 2-(4-(3-isopropyl-2-(8-methylquinoxalin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (394); 
 2-(4-(3-isopropyl-2-(8-methylquinoxalin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (395); 
 2-(4-(3-isopropyl-2-(2,3,8-trimethylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (396); 
 2-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (397); 
 2-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (398); 
 2-(4-(2-(3-fluoro-2-methylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (399); 
 2-(4-(2-(3-fluoro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (400); 
 2-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-(2,2,2-trifluoroethyl)acetamide (401); 
 2-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-isopropylacetamide (402); 
 2-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (403); 
 2-(4-(2-(5-ethoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (404); 
 2-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (405); 
 2-(4-(3-isopropyl-2-(7-methylthiazolo[5,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (406); 
 2-(4-(3-isopropyl-2-(7-methylthiazolo[5,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (407); 
 2-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (408); 
 2-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (409); 
 2-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (410); 
 2-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (411); 
 2-(4-(2-(7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (412); 
 2-(4-(2-(7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (413); 
 2-(4-(2-(8-chloro-7-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (414); 
 2-(4-(2-(8-chloro-7-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (415); 
 2-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (416); 
 2-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (417); 
 2-(4-(2-(8-ethyl-7-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (418); 
 2-(4-(2-(2,7-dimethylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (419); 
 2-(4-(2-(2,7-dimethylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (420); 
 2-(4-(3-isopropyl-2-(5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (421); 
 2-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (422); 
 2-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (423); 
 2-(4-(3-isopropyl-2-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (424); 
 2-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (425); 
 2-(4-(2-(imidazo[1,2-a]pyrazin-3-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (426); 
 2-(4-(3-isopropyl-2-(7-(trifluoromethyl) imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (427); 
 2-(4-(2-(7-chloroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (428); 
 2-(4-(3-isopropyl-2-(2,3,8-trimethylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylacetamide (429); 
 2-(4-(2-(3-cyano-8-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (430); 
 2-(4-(3-isopropyl-2-(7-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (431); 
 6-(5-(1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-8-methoxy-N,N-dimethylimidazo[1,2-a]pyridine-2-carboxamide (432); 
 2-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (433); 
 2-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (434); 
 2-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (435); 
 2-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetamide (436); 
 2-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (437); 
 2-(4-(2-(6-fluoro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylacetamide (438); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (439); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (440); 
 2-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (441); 
 2-(4-(3-isopropyl-2-(7-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (442); 
 2-(4-(3-isopropyl-2-(7-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (443); 
 2-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (444); 
 2-(4-(3-(2,2-difluoroethyl)-2-(imidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (445); 
 2-(4-(3-(2,2-difluoroethyl)-2-(imidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (446); 
 2-(4-(3-isopropyl-2-(8-methylimidazo[1,2-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylacetamide (447); 
 2-(4-(3-isopropyl-2-(8-methylimidazo[1,2-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylacetamide (448); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethanone (449); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1-(methylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethanone (450); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methoxy-7-methyl-[,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (451); 
 1-(4-(2-([1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (452); 
 1-(4-(2-(7,8-dimethyl-[,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (453); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methyl-[,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (454); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methyl-[,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (455); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (456); 
 1-(4-(2-(1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (457); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(4-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (458); 
 1-(4-(2-(1,2-dimethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (459); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (460); 
 2-amino-1-(4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) ethan-1-one (461); 
 1-(4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (462); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (463); 
 1-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-i-one (464); 
 1-(4-(2-([1,2,3]triazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-1-one (465); 
 1-(4-(2-([1,2,4]triazolo[4,3-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-i-one (466); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(4-methyl-[1,2,3]triazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (467); 
 2-(dimethylamino)-1-(4-(2-(7,8-dimethyltetrazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (468); 
 2-(dimethylamino)-1-(4-(2-(5,8-dimethyltetrazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (469); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(pyrrolidin-1-yl) ethan-1-one (470); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethan-1-one (471); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(piperidin-1-yl)ethan-1-one (472); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(2,2,6,6-tetramethylmorpholino)ethan-1-one (473); 
 2-(4-fluoropiperidin-l1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl) ethan-1-one (474); 
 2-(ethyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (475); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-morpholinoethan-1-one (476); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (477); 
 2-(3,3-difluoropyrrolidin-1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (478); 
 2-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (479); 
 2-(isopropyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (480); 
 2-(tert-butyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (481); 
 2-(4,4-difluoropiperidin-1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (482); 
 2-(cyclopropyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (483); 
 2-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (484); 
 2-(1,1-dioxidothiomorpholino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (485); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (486); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(3-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (487); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (488); 
 5-(5-(1-(dimethylglycyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-3,7-dimethylbenzo[d]oxazol-2(3H)-one (489); 
 5-(5-(1-(dimethylglycyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-7-methylbenzo[d]oxazol-2(3H)-one (490); 
 2-(dimethylamino)-1-(4-(2-(2,7-dimethylbenzo[d]oxazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (491); 
 2-(dimethylamino)-1-(4-(2-(8-(hydroxymethyl)imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (492); 
 2-(dimethylamino)-1-(4-(2-(8-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl) ethan-1-one (493); 
 6-(5-(1-(dimethylglycyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-N-(2-hydroxyethyl)-N, 8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (494); 
 6-(5-(1-(dimethylglycyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-N,8-dimethylimidazo[1,2-a]pyridine-2-carboxamide (495); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (496); 
 2-(dimethylamino)-1-(4-(2-(5-ethoxy-2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (497); 
 2-(dimethylamino)-1-(4-(2-(5-ethoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (498); 
 2-(dimethylamino)-1-(4-(2-(2,5-dimethylimidazo[1,2-a]pyridin-7-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (499); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (500); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methoxyimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (501); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (502); 
 1-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (503); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (504); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (505); 
 5-(5-(1-(dimethylglycyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)quinoline-8-carbonitrile (506); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (507); 
 1-(4-(3-isopropyl-2-(8-(trifluoromethyl) imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (508); 
 2-(dimethylamino)-1-(4-(2-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (509); 
 1-(4-(2-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (510); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (511); 
 1-(4-(2-(8-chloroquinolin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-1-one (512); 
 ((2R,3R)-3-hydroxypyrrolidin-2-yl)(4-(3-isopropyl-2-(pyrazzolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl) piperidin-1-yl)methanone (513); 
 1-(4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-1-one (514); 
 1-(4-(2-(2,5-dimethyl-[,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino) ethan-1-one (515); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methyl-[,2,4]triazolo[1,5-a]pyridin-8-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (516); 
 1-(4-(3-(2,2-difluoroethyl)-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (517); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methylquinoxalin-6-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (518); 
 2-(((1 s,4s)-4-aminocyclohexyl)amino)-1-(4-(3-ethyl-2-(1-methyl-1H-indazol-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (519); 
 2-(dimethylamino)-1-(4-(3-ethyl-2-(1-methyl-1H-indazol-4-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (520); 
 1-(4-(3-ethyl-2-(1-methyl-1H-indazol-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(4-methyl-1,4-diazepan-1-yl)ethan-1-one (521); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(3-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (522); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (523); 
 2-(dimethylamino)-1-(4-(2-(7-isobutyl-2-methylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (524); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[4,3-b]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (526); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2,3,8-trimethylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (527); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (528); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (529); 
 1-(4-(3-isopropyl-2-(5-methylimidazo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (530); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methylimidazo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (531); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (532); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (533); 
 1-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (534); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (535); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (536); 
 ((2S,4R)-4-hydroxypyrrolidin-2-yl)(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)methanone (537); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (538); 
 ((2S,4R)-4-hydroxypyrrolidin-2-yl)(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)methanone (539); 
 ((2S,4R)-4-hydroxypyrrolidin-2-yl)(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)methanone (540); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(5-methoxy-2-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl) ethan-1-one (541); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (542); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methylthiazolo[5,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (543); 
 2-(dimethylamino)-1-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (544); 
 1-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (545); 
 1-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (546); 
 1-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (547); 
 1-(4-(2-(7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (548); 
 2-(dimethylamino)-1-(4-(2-(7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (549); 
 1-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (550); 
 1-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (551); 
 2-(dimethylamino)-1-(4-(2-(2,7-dimethylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (552); 
 1-(4-(3-isopropyl-2-(5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (553); 
 1-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(dimethylamino)ethan-1-one (554); 
 1-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (555); 
 1-(4-(2-(7-chloro-1H-indazol-4-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1l-yl)-2-(dimethylamino)ethan-1-one (556); 
 1-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylamino)ethan-1-one (557); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (558); 
 1-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (559); 
 1-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(methylamino)ethan-1-one (560); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (562); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (563); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (564); 
 2-(1H-imidazol-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (565); 
 (S)-1-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidine-1-carbonyl) pyrrolidin-1-yl)ethan-1-one (566); 
 N-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-oxoethyl)acetamide (567); 
 N,N-diethyl-1-(2-(4-(3-isopropyl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-oxoethyl)piperidine-3-carboxamide (568); 
 N,N-diethyl-1-(2-(4-(3-isopropyl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-oxoethyl)piperidine-3-carboxamide (569); 
 2-(dimethylamino)-1-(4-(3-isopropyl-2-(7-methylpyrazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (570); 
 1-(4-(3-(2,2-difluoroethyl)-2-(imidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(dimethylamino)ethan-1-one (571); 
 2-(dimethylamino)-1-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (572); 
 N-(2-((2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-oxoethyl)amino)ethyl)acetamide (573); 
 2-(4-acetylpiperazin-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (574); 
 2-((3-(dimethylamino)propyl)amino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (575); 
 2-(4-(hydroxymethyl)piperidin-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (576); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(4-methyl-1,4-diazepan-1-yl)ethan-1-one (577); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(isopropylamino)ethan-1-one (578); 
 (R)-2-(3-hydroxypyrrolidin-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (579); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-((2-methyl-2-morpholinopropyl)amino)ethan-1-one (580); 
 (S)—N-(1-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-oxoethyl)pyrrolidin-3-yl)acetamide (581); 
 (R)-2-(3-(dimethylamino)pyrrolidin-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (582); 
 2-(sec-butylamino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-one (583); 
 (S)-1-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-oxoethyl)pyrrolidine-2-carboxamide (584); 
 2-(isopropyl(methyl)amino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (585); 
 2-(4-acetyl-1,4-diazepan-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (586); 
 4-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-oxoethyl) piperazin-2-one (587); 
 N,N-diethyl-1-(2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-oxoethyl)piperidine-3-carboxamide (588); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(neopentylamino)ethan-1-one (589); 
 (S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (590); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-2-(4-(pyridin-4-yl)piperazin-1-yl)ethan-1-one (591); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl) ethan-1-one (592); 
 (S)-3-hydroxy-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)butan-1-one (593); 
 (R)-3-hydroxy-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)butan-1-one (594); 
 (S)-3-hydroxy-1-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl) piperidin-1-yl)butan-1-one (595); 
 1-(4-(2-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-3-hydroxybutan-1-one (596); 
 1-(4-(2-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-3-hydroxy-3-methylbutan-1-one (597); 
 (S)-1-(4-(2-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-3-hydroxybutan-1-one (598); 
 (S)-3-hydroxy-1-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-1H-indol-5-yl)piperidin-1-yl)butan-1-one (599); 
 (S)-3-hydroxy-1-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)butan-1-one (600); 
 3-hydroxy-1-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-3-methylbutan-1-one (601); 
 (S)-3-hydroxy-1-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)butan-1-one (602); 
 (R)-1-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-3-hydroxybutan-1-one (603); 
 (S)-1-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-3-hydroxybutan-1-one (604); 
 (R)-1-(4-(2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-3-hydroxybutan-1-one (605); 
 1-(4-(3-(2,2-difluoroethyl)-2-(8-fluoroimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-3-hydroxy-3-methylbutan-1-one (606); 
 1-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-3-hydroxy-3-methylbutan-1-one (607); 
 (S)-1-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-hydroxybutan-1-one (608); 
 (R)-1-(4-(3-(2,2-difluoroethyl)-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-hydroxybutan-1-one (609); 
 (4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (1H-pyrazol-4-yl)methanone (610); 
 (4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (thiazol-4-yl)methanone (611); 
 2-(1H-imidazol-4-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-one (612); 
 4-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethyl-4-oxobutanamide (613); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-(methylsulfonyl)ethan-1-one (614); 
 (4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (1H-pyrazol-3-yl)methanone (615); 
 2-((4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)sulfonyl) ethan-1-ol (616); 
 2-((4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)sulfonyl)-N,N-dimethylethan-1-amine (617); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-(pyrrolidin-1-yl)propan-1-one (618); 
 1-(4-(2-(7,8-dimethyltetrazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-3-morpholinopropan-1-one (619); 
 3-(dimethylamino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (620); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-(2,2,6,6-tetramethylmorpholino)propan-1-one (621); 
 3-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) iperidin-1-yl)propan-1-one (622); 
 3-(cyclopropyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (623); 
 3-(isopropyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (624); 
 3-(ethyl(methyl)amino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (625); 
 3-(3,3-difluoropyrrolidin-1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (626); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-morpholinopropan-1-one (627); 
 3-(4,4-difluoropiperidin-1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (628); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-(piperidin-1-yl)propan-1-one (629); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)propan-1-one (631); 
 3-(2-azabicyclo[3.1.0]hexan-2-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (632); 
 3-(4-fluoropiperidin-1-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (633); 
 3-(1,1-dioxidothiomorpholino)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (634); 
 3-((1R,5S)-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)propan-1-one (635); 
 (4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (piperidin-3-yl)methanone (636); 
 (S)-3-amino-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)butan-1-one (637); 
 4-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl)piperidine-1-carbonyl)-1-methylpyrrolidin-2-one (638); 
 (R)-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl) (piperidin-3-yl)methanone (639); 
 (S)-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl) (piperidin-3-yl)methanone (640); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-3-(piperidin-1-yl)propan-1-one (641); 
 3-(1H-imidazol-1-yl)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (642); 
 3-(dimethylamino)-1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)propan-1-one (643); 
 4-(4-(3-(2,2-difluoroethyl)-2-(imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidine-1-carbonyl)-1-methylpyrrolidin-2-one (644); 
 4-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidine-1-carbonyl)-1-methylpyrrolidin-2-one (645); 
 1-(4-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidine-1-carbonyl)piperidin-1-yl) ethan-1-one (646); 
 (4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (piperidin-4-yl)methanone (647); 
 (4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)(1-methylpiperidin-4-yl)methanone (648); 
 (4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) (piperidin-4-yl)methanone (649); 
 2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethanamine dihydrochloride (650); 
 2-(4-(2-([1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (651); 
 N-(2-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethyl) methanesulfonamide (652); 
 4-(5-([1,3′-bipiperidin]-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (653); 
 2-(4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (654); 
 2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) ethan-1-amine (655); 
 2-(4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (656); 
 1-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl) cyclopropan-1-amine (657); 
 2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylethan-1-amine (658); 
 N-methyl-2-(4-(3-methyl-2-(quinoxalin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (659); 
 2-(4-(2-(benzo[d]thiazol-5-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (659); 
 4-(5-(1-(2-(azepan-1-yl)ethyl) piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (660); 
 N,N-diethyl-2-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-amine (661); 
 N-methyl-2-(4-(3-methyl-2-(quinolin-8-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (662); 
 2-(4-(2-(isoquinolin-4-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (663); 
 N-methyl-2-(4-(3-methyl-2-(quinolin-3-yl)-1H-indol-5-yl) piperidin-1-yl)ethan-1-amine (664); 
 2-(4-(2-(isoquinolin-4-yl)-3-methyl-1H-indol-5-yl) piperidin-1-yl)-N-methylethan-1-amine (665); 
 N-methyl-2-(4-(3-methyl-2-(quinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (666); 
 N-methyl-2-(4-(3-methyl-1H, 1′H-[2,5′-biindol]-5-yl)piperidin-1-yl)ethan-1-amine (667); 
 N-methyl-2-(4-(3-methyl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (668); 
 2-(4-(2-(2,3-dihydrobenzofuran-5-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (669); 
 2-(4-(2-(benzo[d][1,3]dioxol-5-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (670); 
 2-(4-(2-(5-methoxybenzofuran-2-yl)-3-methyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (671); 
 2-(4-(1′,3-dimethyl-1H, 1′H-[2,5′-biindol]-5-yl)piperidin-1-yl)-N-methylethan-1-amine (672); 
 N-methyl-2-(4-(3-methyl-2-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-1H-indol-5-yl)piperidin-1-yl)ethan-1-amine (673); 
 2-(3,3-difluoro-4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylethan-1-amine (674); 
 2-(3-fluoro-4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylethan-1-amine (675); 
 2-(4-(3-isopropyl-2-(2-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (676); 
 2-(3-fluoro-4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N-methylethan-1-amine (677-679); 
 2-(4-(2-(imidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (680); 
 2-(4-(3-(2,2-difluoroethyl)-2-(imidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine (681); 
 4-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (682); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-b]pyridazine (683); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazine (684); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazine (685); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methyl-[1,2,4]triazolo[1,5-b]pyridazine (686); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,4]triazolo[1,5-b]pyridazine (687); 
 5-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (688); 
 3-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridine (689); 
 3-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-1H-pyrrolo[2,3-b]pyridine (690); 
 3-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-1,2-dimethyl-1H-pyrrolo[2,3-b]pyridine (691); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (692); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (693); 
 3-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (694); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (695); 
 5-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (696); 
 7-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine (697); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (698); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazolo[1,5-a]pyridine (699); 
 5-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (700); 
 5-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (701); 
 8-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (702); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoline (703); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoline (704); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine (705); 
 6-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl) piperidin-4-yl)-1H-indol-2-yl)-8-methoxyimidazo[1,2-a]pyridine (706); 
 7-(3-isopropyl-5-(1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,5-a]pyridine (707); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methylbenzo[d]oxazol-2(3H)-one (708); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-2,7-dimethylbenzo[d]oxazole (709); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridine (710); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,2-a]pyridine (711); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methoxyimidazo[1,2-a]pyridine (712); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (713); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)quinoline-8-carbonitrile (714); 
 8-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyridine (715); 
 7-isobutyl-5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyridine (716); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-2,8-dimethylimidazo[1,2-a]pyridine (717); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indol-2-yl)-7-methylthiazolo[5,4-b]pyridine (718); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methylimidazo[1,2-a]pyridine (719); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methylpyrazolo[1,5-a]pyridine (720); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidine (721); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxyimidazo[1,2-a]pyridine (722); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methylquinoline (723); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methylimidazo[1,5-a]pyridine (724); 
 4-(3-isopropyl-5-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indol-2-yl)-2-methylquinoline (725); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indol-2-yl)-2-methylpyrazolo[1,5-a]pyridine (726); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridine (727); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-2-methyl-[1,2,4]triazolo[1,5-a]pyridine (728); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[1,5-b]pyridazine (729); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazine (730); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazine (731); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (732); 
 3-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (733); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (734); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (735); 
 7-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine (736); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (737); 
 (6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)tetrazolo[1,5-a]pyridin-8-yl)methanol (738); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyltetrazolo[1,5-a]pyridine (739); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl) piperidin-4-yl)-1H-indol-2-yl)-5,8-dimethyltetrazolo[1,5-a]pyridine (740); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (741); 
 6-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazolo[1,5-a]pyridine (742); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (743); 
 5-(3-isopropyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,3]triazolo[1,5-a]pyridine (744); 
 1-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol, TFA (745); 
 1-(4-(2-([1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (746); 
 1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-3-isopropyl-H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (747); 
 1-(4-(3-isopropyl-2-(8-methoxy-7-methyl-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (748); 
 1-(4-(3-isopropyl-2-(8-methoxy-[1,2,4]triazolo[1,5-b]pyridazin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (749); 
 1-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (750); 
 1-(4-(3-isopropyl-2-(2-methylquinolin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (752); 
 1-(4-(3-isopropyl-2-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (753); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-3-methoxypropan-1-ol (754); 
 2-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)propane-1,3-diol (755); 
 1-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (756); 
 1-(4-(3-isopropyl-2-(5-methylimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (757); 
 1-(4-(3-isopropyl-2-(5-methoxyimidazo[1,2-a]pyridin-7-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (758); 
 1-(4-(3-isopropyl-2-(pyrazolo[1,5-a]pyrimidin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (759); 
 1-(4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (760); 
 1-(4-(2-(imidazo[1,2-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (761); 
 1-(4-(2-(1,7-dimethyl-1H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (762); 
 1-(4-(2-(1,4-dimethyl-1H-indazol-5-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (763); 
 1-(4-(3-isopropyl-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (764); 
 1-(4-(3-isopropyl-2-(2-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (765); 
 5-(5-(1-(2-hydroxy-2-methylpropyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl) quinoline-8-carbonitrile (766); 
 1-(4-(2-(8-chloroquinolin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (767); 
 1-(4-(2-(2,5-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-3-isopropyl-H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (768); 
 1-(4-(3-isopropyl-2-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (769); 
 1-(4-(2-(7-isobutyl-2-methylpyrazolo[1,5-a]pyridin-5-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (770); 
 1-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (771); 
 1-(4-(2-(8-chloro-7-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (772); 
 1-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (773); 
 1-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (774); 
 1-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (775); 
 1-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-2-methylpropan-2-ol (776); 
 1-(4-(2-(8-ethyl-7-methylimidazo[1,2-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl) piperidin-1-yl)-2-methylpropan-2-ol (777); 
 5-(3-isopropyl-5-(1-(2-methoxyethyl)piperidin-4-yl)-1H-indol-2-yl)quinoline-8-carbonitrile (778); 
 7-(3-isopropyl-5-(1-(2-methoxyethyl)piperidin-4-yl)-1H-indol-2-yl)-5-methyl-[1,2,4]triazolo[1,5-a]pyridine (779); 
 7-(3-isopropyl-5-(1-(2-methoxyethyl)piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridine (780); 
 (6-(3-isopropyl-5-(1-((3-methyloxetan-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl) tetrazolo[1,5-a]pyridin-8-yl)methanol (781); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (782); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)ethane-1-sulfonamide (783); 
 4-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (784); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (785); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyltetrazolo[1,5-a]pyridine (786); 
 6-(3-isopropyl-5-(1-(3-(methylsulfonyl)propyl) piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (787); 
 4-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (788); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (789); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl) piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazolo[1,5-a]pyridine (790); 
 4-(4-(3-isopropyl-2-(7-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (791); 
 4-(4-(3-isopropyl-2-(3-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (792); 
 5-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (793); 
 4-(4-(3-isopropyl-2-(7-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (794); 
 5-(3-isopropyl-5-(1-(2-(methyl sulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,3]triazolo[1,5-a]pyridine (795); 
 5-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl) quinoline-8-carbonitrile (796); 
 7-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridine (797); 
 4-(4-(2-([1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (798); 
 4-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl) piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (799); 
 4-(4-(3-isopropyl-2-(8-methylquinolin-6-yl)-1H-indol-5-yl)piperidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (800); 
 6-(3-isopropyl-5-(1-(2-(methylsulfonyl)ethyl)piperidin-4-yl)-1H-indol-2-yl)-8-methoxyimidazo[1,2-a]pyridine (801); 
 5-(3-isopropyl-5-(1′-methyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (802); 
 6-(3-isopropyl-5-(1′-isopropyl-[,4′-bipiperidin]-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (803); 
 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-[,4′-bipiperidin]-3′-ol (804); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-imidazo[4,5-c]pyridine (805); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)pyrrolo[2,1-f][1,2,4]triazine (806); 
 8-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)imidazo[1,2-b]pyridazine (807); 
 2-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-5H-pyrrolo[3,2-d]pyrimidine (808); 
 2-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (809); 
 4-(3-methyl-5-(′-methyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (810); 
 4-(5-(1′-ethyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (811); 
 4-(5-(1′-isobutyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (812); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (813); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (814); 
 6-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-9H-purine (815); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-pyrazolo[3,4-d]pyrimidine (816); 
 6-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-9-methyl-9H-purine (817); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (818); 
 5-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (819); 
 4-(3-isopropyl-5-(2′-methyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (820); 
 4-(3-isopropyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (821); 
 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-[1,4′-bipiperidin]-2′-one (822); 
 1-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-[1,4′-bipiperidin]-1′-yl)ethan-1-one (823); 
 4-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (824); 
 methyl 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-[1,4′-bipiperidine]-2′-carboxylate (825); 
 4-(3-isopropyl-5-(1′-isopropyl-[,4′-bipiperidin]-4-yl)-6-methyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (826); 
 4-(5-(3′-fluoro-[,4′-bipiperidin]-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (827); 
 4-(5-(1-(azepan-4-yl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (828); 
 4-(3-isopropyl-5-(1-((1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (829); 
 4-(6-fluoro-3-isopropyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (830); 
 methyl 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-[1,4′-bipiperidine]-2′-carboxylate (831); 
 4-(5-([1,4′-bipiperidin]-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (832); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (833); 
 4-(3-isopropyl-5-(3′-methyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (834); 
 ethyl 4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)-3′-methyl-[1,4′-bipiperidine]-1′-carboxylate (835); 
 6-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine (836); 
 4-(3-ethyl-5-(1′-ethyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (837); 
 4-(3-ethyl-5-(2′,2′,6′,6′-tetramethyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (838); 
 4-(3-ethyl-5-(1′-methyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (839); 
 4-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-6-methyl-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (840); 
 6-(3-isopropyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-7-methylimidazo[1,2-a]pyridine (841); 
 3-chloro-4-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (842); 
 4-(5-(1′-isobutyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (843); 
 4-(5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-3-methyl-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (844); 
 3-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylpropan-1-amine (845); 
 3-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N,2-trimethylpropan-1-amine (846); 
 3-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N,2,2-tetramethylpropan-1-amine (847); 
 4-(3-isopropyl-5-(1-(3-(piperidin-1-yl)propyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (848); 
 4-(3-ethyl-5-(1′-isobutyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (849); 
 4-(3-ethyl-5-(1′-isopropyl-[1,4′-bipiperidin]-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (850); 
 4-(3-isopropyl-5-(1-(pyrrolidin-3-ylmethyl)piperidin-4-yl)-6-(trifluoromethyl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (851); 
 4-(6-fluoro-3-isopropyl-5-(1-((1-isopropylpyrrolidin-3-yl) methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (852); 
 4-(6-fluoro-3-isopropyl-5-(1-(pyrrolidin-3-ylmethyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (853); 
 4-(3-isopropyl-5-(1-((1-isopropylpyrrolidin-3-yl)methyl)piperidin-4-yl)-6-(trifluoromethyl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (854); 
 3-(4-(6-fluoro-3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)-N,N-dimethylpropan-1-amine (855); 
 3-(4-(3-isopropyl-2-(7-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)-N,N-dimethylpropan-1-amine (856); 
 4-(3-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)propyl)morpholine (857); 
 4-(3-(4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) propyl) morpholine (858); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl) methyl)-2-isopropylthiazole (859); 
 6-(5-(1-((1H-1,2,3-triazol-5-yl)methyl) piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (860); 
 7-(3-isopropyl-5-(1-((4-methyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-3H-imidazo[4,5-b]pyridine (861); 
 4-(5-(1-(imidazo[1,2-a]pyridin-2-ylmethyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (862); 
 4-(5-(1-((1H-imidazol-5-yl) methyl)piperidin-4-yl)-3-ethyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (863); 
 4-(3-isopropyl-5-(1-((4-methyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (864); 
 4-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl) piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (865); 
 4-(3-isopropyl-5-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (866); 
 2-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl) oxazole (867); 
 4-(3-isopropyl-5-(1-((3-methylimidazo[1,5-a]pyridin-1-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (868); 
 4-(3-isopropyl-5-(1-((2-methyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (869); 
 4-(5-(1-((1H-imidazol-4-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (870); 
 4-(3-ethyl-5-(1-((1-methyl-1H-pyrrol-2-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrrolo[2,3-b]pyridine (871); 
 4-(3-isopropyl-5-(1-((2-methyl-1H-imidazol-5-yl)methyl) piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (872); 
 4-(5-(1-((1H-imidazol-5-yl)methyl)piperidin-4-yl)-3-ethyl-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (873); 
 4-(3-isopropyl-5-(1-((4-methyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (874); 
 4-(5-(1-((1H-imidazol-5-yl)methyl) piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine (875); 
 3-(3-isopropyl-5-(1-((2-methylpyrimidin-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (876); 
 3-(5-(1-((1H-1,2,3-triazol-5-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (877); 
 3-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine (878); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl) piperidin-4-yl)-1H-indol-2-yl)-[1,2,3]triazolo[1,5-a]pyridine (879); 
 7-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-[1,2,4]triazolo[4,3-a]pyridine (880); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (881); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (882); 
 6-(5-(1-((1H-1,2,3-triazol-5-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (883); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (884); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (885); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazolo[1,5-a]pyridine (886); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-7-methyltetrazolo[1,5-a]pyridine (887); 
 5-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-3-yl) methyl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (888); 
 5-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-3-methyl-[1,2,3]triazolo[1,5-a]pyridine (889); 
 5-(3-isopropyl-5-(1-((1-methyl-1H-1,2,4-triazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,3]triazolo[1,5-a]pyridine (890); 
 5-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-3-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-7-methyl-[1,2,3]triazolo[1,5-a]pyridine (891); 
 4-(5-(1-((2H-1,2,3-triazol-4-yl)methyl)piperidin-4-yl)-3-ethyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (892); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)-3,5-dimethylisoxazole (893); 
 N-(2-(4-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)methyl)phenoxy)ethyl)-N-methylpyridin-2-amine (894); 
 3-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)quinoline (895); 
 4-(5-(1-((2-butyl-4-chloro-1H-imidazol-5-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (896); 
 3-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)-5-phenylisoxazole (897); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)-2,5-dimethyloxazole (898); 
 4-(3-isopropyl-5-(1-(4-(pyrimidin-2-yloxy)benzyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (899); 
 4-(3-ethyl-5-(1-((3-methyl-1H-pyrazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (900); 
 4-(3-ethyl-5-(1-((1-methyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (901); 
 2-chloro-3-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)methyl)-6-methoxyquinoline (902); 
 4-(3-isopropyl-5-(1-(pyrazin-2-ylmethyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (903); 
 4-(5-(1-((1H-imidazol-5-yl)methyl) piperidin-4-yl)-3-ethyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (904); 
 4-(3-isopropyl-5-(1-(4-(pyrrolidin-1-yl)benzyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (905); 
 4-(3-isopropyl-5-(1-((1-methyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (906); 
 4-(3-isopropyl-5-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (907); 
 4-(3-ethyl-5-(1-((2-phenyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (908); 
 4-(3-isopropyl-5-(1-((2-methoxypyrimidin-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (909); 
 1-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl) isoquinoline (910); 
 4-(3-ethyl-5-(1-((1-methyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (911); 
 4-(4-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)phenyl)morpholine (912); 
 4-(5-(1-((2-chloro-5-fluoropyridin-3-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (913); 
 4-(5-(1-((1H-imidazol-2-yl) methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (914); 
 4-(3-ethyl-5-(1-((2-ethyl-1H-imidazol-5-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (915); 
 4-(3-ethyl-5-(1-((4-methyl-1H-imidazol-5-yl)methyl) piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (916); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)-2-methyloxazole (917); 
 4-(5-(1-((1H-imidazol-4-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (918); 
 4-(3-isopropyl-5-(1-(4-(4-methylpiperazin-1-yl)benzyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (919); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)oxazole (920); 
 3-(2-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)methyl)phenoxy)-N,N-dimethylpropan-1-amine (921); 
 2-chloro-3-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl) piperidin-1-yl)methyl)-8-methylquinoline (922); 
 4-(5-(1-((3-chloropyridin-4-yl)methyl) piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (923); 
 4-((dimethylamino)methyl)-2-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)methyl)-6-methoxyphenol (924); 
 4-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazol-2-amine (925); 
 5-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazol-2-amine (926); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazole (927); 
 5-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazole (928); 
 2-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazole (929); 
 4-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)-1,2,3-thiadiazole (930); 
 5-((4-(3-ethyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl) methyl)thiazol-2-amine (931); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (932); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine (933); 
 6-(3-isopropyl-5-(1-((1-methyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-2-methyl-8-(trifluoromethyl) imidazo[1,2-a]pyridine (934); 
 6-(3-isopropyl-5-(1-((6-methoxypyridin-3-yl)methyl) piperidin-4-yl)-1H-indol-2-yl) imidazo[1,2-a]pyridine (935); 
 6-(5-(1-((1H-imidazol-4-yl) methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (936); 
 6-(3-isopropyl-5-(1-((2-methyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (937); 
 6-(3-isopropyl-5-(1-((2-methyl-1H-imidazol-4-yl) methyl)piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (938); 
 6-(3-(2,2-difluoroethyl)-5-(1-((2-methyl-1H-imidazol-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (939); 
 6-(5-(1-((1H-imidazol-4-yl)methyl)piperidin-4-yl)-3-isopropyl-1H-indol-2-yl) imidazo[1,2-a]pyridine (940); 
 6-(5-(1-((1H-imidazol-4-yl)methyl)piperidin-4-yl)-3-(2,2-difluoroethyl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (941); 
 6-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)-8-(trifluoromethyl) imidazo[1,2-a]pyridine (942); 
 6-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine (943); 
 6-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)pyrazolo[1,5-a]pyrimidine (944); 
 6-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)-2-methylimidazo[1,2-a]pyridine (945); 
 6-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (946); 
 6-(3-isopropyl-5-(1-methylpiperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (947); 
 6-(3-(2,2-difluoroethyl)-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)imidazo[1,2-a]pyridine (948); 
 5-(3-isopropyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)quinoline-8-carbonitrile (949); 
 2-(4-(3-isopropyl-2-(8-methoxyimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetonitrile (950); 
 2-(4-(3-isopropyl-2-(8-methylimidazo[1,2-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetonitrile (951); 
 6-(3-isopropyl-5-(1-propylpiperidin-4-yl)-1H-indol-2-yl)-8-methoxy-[1,2,4]triazolo[1,5-b]pyridazine (952); 
 5-(3-isopropyl-5-(1-propylpiperidin-4-yl)-1H-indol-2-yl)isobenzofuran-1(3H)-one (953); 
 6-(3-isopropyl-5-(1-propylpiperidin-4-yl)-1H-indol-2-yl)-1,4-dimethyl-1H-benzo[d]imidazole (954); 
 6-(5-(1-isobutylpiperidin-4-yl)-3-isopropyl-1H-indol-2-yl)-4-methyl-1H-benzo[d]imidazole (955); 
 5-(3-isopropyl-5-(1-propylpiperidin-4-yl)-1H-indol-2-yl)-1,7-dimethyl-1H-benzo[d]imidazole (956); 
 4-(3-ethyl-5-(1-isopropylpiperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (957); 
 2-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)acetonitrile (958); 
 3-(4-(3-isopropyl-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indol-5-yl) piperidin-1-yl)propanenitrile (959); 
 6-(3-isopropyl-5-(1-(4,4,4-trifluorobutyl)piperidin-4-yl)-1H-indol-2-yl)-4-methyl-[1,2,3]triazolo[1,5-a]pyridine (960); 
 2-(4-(3-isopropyl-2-(8-methyltetrazolo[1,5-a]pyridin-6-yl)-1H-indol-5-yl)piperidin-1-yl)acetonitrile (961); 
 6-(3-isopropyl-5-(1-(3,3,3-trifluoropropyl) piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (962); 
 6-(3-isopropyl-5-(1-(4,4,4-trifluorobutyl)piperidin-4-yl)-1H-indol-2-yl)-8-methyltetrazolo[1,5-a]pyridine (963); 
 2-(4-(3-isopropyl-2-(7-methyl-[1,2,3]triazolo[1,5-a]pyridin-5-yl)-1H-indol-5-yl) piperidin-1-yl)acetonitrile (964); 
 3-(4-((4-(3-isopropyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-1H-indol-5-yl)piperidin-1-yl)methyl)phenoxy)-N,N-dimethylpropan-1-amine (965); 
 4-(6-fluoro-3-isopropyl-5-(1-((1-isopropylpiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (966); and 
 4-(4-fluoro-3-isopropyl-5-(1-((1-isopropylpiperidin-4-yl)methyl)piperidin-4-yl)-1H-indol-2-yl)-1H-pyrazolo[3,4-b]pyridine (967).
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