US2021261635A1PendingUtilityA1

Compositions and methods for using actin-based peptides to modulate cellular bioactivity and cellular susceptibility to intracellular pathogens

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Assignee: VIRONGY L L CPriority: Jul 2, 2016Filed: May 11, 2021Published: Aug 26, 2021
Est. expiryJul 2, 2036(~9.9 yrs left)· nominal 20-yr term from priority
Inventors:Yuntao Wu
A61K 38/00C07K 2319/10A61P 35/00C07K 14/4716A61K 38/1719A61K 47/64A61K 47/51
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Claims

Abstract

Compositions and methods for using actin-based peptides to modulate cellular bioactivity, including modulation of cellular susceptibility to intracellular pathogens, such as bacteria and viruses.

Claims

exact text as granted — not AI-modified
1 - 21 . (canceled) 
     
     
         22 . An actin-based peptide, comprising
 an actin core domain and a cell penetration domain, operably linked together by a a spacer domain,   wherein an N-terminus or C-terminus may have either the actin core domain or the cell penetration domain, and   wherein the actin core domain is N7 types selected from SEQ ID NOs: 2, 8, 9, 139-290.

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