Noribogaine compositions

Abstract

Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.

What is claimed is: 
     
         1 . A composition comprising noribogaine wherein at least 95% of the noribogaine is present as the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and further wherein said composition comprises not more than 0.5 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         2 . The composition of  claim 1 , wherein said composition comprises not more than 0.3 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         3 . The composition of  claim 1 , wherein said composition comprises not more than 0.1 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         4 . The composition of  claim 1 , wherein said composition comprises less than 800 ppm ibogaine. 
     
     
         5 . The composition of  claim 1 , wherein at least 98% of the noribogaine is present as the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer. 
     
     
         6 . A composition comprising noribogaine wherein at least 98% of the noribogaine is present as the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and further wherein said composition comprises not more than 0.5 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         7 . The composition of  claim 6 , wherein said composition comprises not more than 0.3 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         8 . The composition of  claim 6 , wherein said composition comprises not more than 0.1 wt % ibogaine relative to the total amount of noribogaine. 
     
     
         9 . A composition comprising noribogaine hydrochloride and isopropanol. 
     
     
         10 . A composition comprising noribogaine, hydrochloric acid at a concentration of 5M, and isopropanol, wherein the composition has a temperature of from 45 to 55° C. 
     
     
         11 . A composition comprising noribogaine, silica gel, methylene chloride, acetonitrile and an organic base. 
     
     
         12 . A composition comprising solid noribogaine hydrochloride and isopropanol.