Use of a cream that protects against the effects of aggressive chemical agents in contact with the skin

Abstract

The use of an emulsion for protecting the skin against aggressive chemical agents, wherein this emulsion includes at least one amphoteric chelating agent which includes a complex based on aluminium and on ethylenediaminetetraacetic acid or the trisodium salt thereof, having the general formula [Al(Y)B n ] C′ D c with B being OH − , BO 2 − or H + , Y being a tetracarboxylate which can be protonated four times to form ethylenediaminetetraacetic acid, n being an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na + , c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c.

1 . A method for protecting the skin against aggressive chemical agents, comprising applying to the skin an emulsion comprising at least one amphoteric chelating agent that comprises a complex based on aluminum and ethylenediaminetetraacetic acid or its trisodium salt having the general formula [Al(Y)B n ] c′ D c  with B representing OH − , BO 2   − , H + , Y representing a tetracarboxylate, which may be protonated four times to form ethylenediaminetetraacetic acid, n representing an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na + , c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c. 
     
     
         2 . The method of  claim 1 , wherein the aggressive chemical agent is selected from categories H311, H312, H314, H315, H317 of the CLP regulations (regulation (EC) No. 1272/2008), the products having a pH from 2 to 11.5 and mixtures thereof. 
     
     
         3 . The method of  claim 1 , wherein the aggressive chemical agent is an allergen. 
     
     
         4 . The method of  claim 3 , wherein the allergen is selected from the group consisting of heavy metals such as Al, As, Cd, Cr, Hg, Ni, Pb, Sr and Te, tetramethylthiuram disulfide, 2-mercaptobenzothiazole, benzyl carbamate, bisphenol, ethyl acrylate, Araldite 506 epoxy resin, hevein, methanal and mixtures thereof. 
     
     
         5 . A method for preventing contact dermatitides, comprising applying to the skin an emulsion comprising at least one amphoteric chelating agent that comprises a complex based on aluminum and ethylenediaminetetraacetic acid or its trisodium salt having the general formula [Al(Y)B n ] c′ D c  with B representing OH − , BO 2   − , Y representing a tetracarboxylate, which may be protonated four times to form ethylenediaminetetraacetic acid, n representing an integer equal to 0, 1, 2 or 3, D being a counterion, preferably Na + , c being an integer equal to 0, 1, 2 or 3 and c′ being a relative number having the same absolute value as c. 
     
     
         6 . The method of  claim 1 , wherein the emulsion is applied evenly on the entire area, at a rate of about 0.5 to 5 mg/cm 2 , preferably about 1 to 3 mg/cm 2 , and even more preferably about 2 mg/cm 2 . 
     
     
         7 . The method of  claim 1 , wherein the emulsion is applied at least 5 minutes, preferably at least 10 minutes and even more preferably at least 15 minutes before contact with an aggressive chemical agent. 
     
     
         8 . The method of  claim 1 , wherein the application of the emulsion is renewed at most every 4 hours, preferably at each washing of the hands. 
     
     
         9 . The method of  claim 1 , wherein the concentration of amphoteric chelating agent is from 0.01 to 5 wt % based on the total weight of the emulsion. 
     
     
         10 . The method of  claim 1 , wherein the amphoteric chelating agent is stabilized with an amino acid selected from the group consisting of glycine, histidine, arginine, lysine, phenylalanine, alanine, isoleucine, leucine, methionine, proline, valine, tryptophan, serine, glutamine, cystine and mixtures thereof. 
     
     
         11 . The method of  claim 1 , wherein the emulsion comprises at least one surfactant, which may be hydrophobic with an HLB from 3 to 10 or hydrophilic with an HLB from 11 to 18. 
     
     
         12 . The method of  claim 11 , wherein the concentration of surfactant is from 0.1 to 10 wt %, preferably from 0.5 to 5 wt %, and even more preferably from 1 to 3 wt % based on the total weight of the emulsion. 
     
     
         13 . The method of  claim 1 , wherein said emulsion is an oil-in-water emulsion. 
     
     
         14 . The emulsion as defined in  claim 1  for use thereof for protecting the skin against aggressive chemical agents. 
     
     
         15 . The method of  claim 5 , wherein the emulsion is applied evenly on the entire area, at a rate of about 0.5 to 5 mg/cm 2 , preferably about 1 to 3 mg/cm 2 , and even more preferably about 2 mg/cm 2 . 
     
     
         16 . The method of  claim 5 , wherein the amphoteric chelating agent is stabilized with an amino acid selected from the group consisting of glycine, histidine, arginine, lysine, phenylalanine, alanine, isoleucine, leucine, methionine, proline, valine, tryptophan, serine, glutamine, cystine and mixtures thereof. 
     
     
         17 . The method of  claim 5 , wherein the emulsion comprises at least one surfactant, which may be hydrophobic with an HLB from 3 to 10 or hydrophilic with an HLB from 11 to 18. 
     
     
         18 . The method of  claim 5 , wherein said emulsion is an oil-in-water emulsion.