Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors

Abstract

The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

1 - 15 . (canceled) 
     
     
         16 . A pharmaceutical composition, comprising:
 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine or a hydrobromic acid addition salt thereof, and   at least one pharmaceutically acceptable carrier or diluent.   
     
     
         17 . The composition of  claim 16 , wherein the composition comprises a hydrobromic acid addition salt of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine. 
     
     
         18 . The composition of  claim 17 , wherein the composition is a tablet. 
     
     
         19 . The composition of  claim 18 , wherein the composition comprises 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine in an amount of from 0.01 mg to 100 mg. 
     
     
         20 . A method for the treatment of an affective disorder in a human in need thereof, comprising administering to the human an amount of the composition of claim  1  comprising a therapeutically effective amount of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine or a hydrobromic acid addition salt thereof. 
     
     
         21 . The method of  claim 20 , wherein the affective disorder is depression. 
     
     
         22 . The method of  claim 20 , wherein the affective disorder is an anxiety disorder. 
     
     
         23 . The method of  claim 22 , wherein the anxiety disorder is general anxiety disorder or panic disorder. 
     
     
         24 . The method of  claim 20 , wherein the affective disorder is obsessive compulsive disorder. 
     
     
         25 . The method of  claim 20 , wherein the composition comprises a therapeutically effective amount of a hydrobromic acid addition salt of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine. 
     
     
         26 . The method of  claim 25 , wherein the affective disorder is depression. 
     
     
         27 . The method of  claim 25 , wherein the affective disorder is an anxiety disorder. 
     
     
         28 . The method of  claim 27 , wherein the anxiety disorder is general anxiety disorder or panic disorder. 
     
     
         29 . The method of  claim 25 , wherein the affective disorder is obsessive compulsive disorder. 
     
     
         30 . The method of  claim 25 , wherein the composition is a tablet. 
     
     
         31 . The method of  claim 30 , wherein the affective disorder is depression. 
     
     
         32 . The method of  claim 30 , wherein the affective disorder is an anxiety disorder. 
     
     
         33 . The method of  claim 32 , wherein the anxiety disorder is general anxiety disorder or panic disorder. 
     
     
         34 . The method of  claim 33 , wherein the affective disorder is obsessive compulsive disorder. 
     
     
         35 . The method of  claim 30 , wherein the composition comprises 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine in an amount of from 0.01 mg to 100 mg. 
     
     
         36 . The method of  claim 35 , wherein the affective disorder is depression. 
     
     
         37 . The method of  claim 35 , wherein the affective disorder is an anxiety disorder. 
     
     
         38 . The method of  claim 37 , wherein the anxiety disorder is general anxiety disorder or panic disorder. 
     
     
         39 . The method of  claim 35 , wherein the affective disorder is obsessive compulsive disorder.