Composition containing mixed extract of mulberry and poria cocos bark

Abstract

The present invention relates to a composition comprising the mixed extract of mulberry and Poria cocos peel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry and Poria cocos peel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

1 .- 15 . (canceled) 
     
     
         16 . A method of improving cognitive abilities or memory in a subject in need thereof, comprising administering a composition comprising an extract of a mixture which comprises (i) mulberry and (ii)  Poria cocos  peel to the subject. 
     
     
         17 . The method of  claim 16 , wherein the mixture of mulberry and  Poria cocos  peel is at a weight ratio of 4 to 7:1. 
     
     
         18 . The method of  claim 16 , wherein the mixture of mulberry and  Poria cocos  peel is at a weight ratio of 5:1. 
     
     
         19 . The method of  claim 16 , wherein the mixture further comprises water, a lower alcohol having 1 to 4 carbon atoms, or both water and a lower alcohol having 1 to 4 carbon atoms. 
     
     
         20 . The method of  claim 16 , wherein the mixture further comprises 60 to 80 (v/v) % of ethanol. 
     
     
         21 . The method of  claim 16 , wherein the composition is in the form of a tablet, a pill, a powder, a granule, or a capsule. 
     
     
         22 . The method of  claim 21 , wherein the composition comprises calcium carbonate, sucrose, lactose, talc, magnesium stearate or any combination thereof. 
     
     
         23 . The method of  claim 16 , wherein the composition is formulated for parenteral administration. 
     
     
         24 . The method of  claim 16 , wherein the composition is administered intrarectally, intravenously, intramuscularly, subcutaneously, intra-uterine, durally, or intracerebroventicularly. 
     
     
         25 . The method of  claim 16 , wherein the subject has a degenerative neurological disease selected from the group consisting of Alzheimer's Dementia, Creutzfeldt-Jakob disease, Huntington's disease, multiple sclerosis, Guilin-Barre syndrome, Parkinson's disease, Lou Gehrig's disease, progressive dementia caused by gradual neuronal death, and progressive Ataxia. 
     
     
         26 . A method of reducing tau phosphorylation in a subject comprising administering an extract of a mixture which comprises (i) mulberry and (ii)  Poria cocos  peel to the subject. 
     
     
         27 . The method of  claim 26 , wherein the mixture of mulberry and  Poria cocos  peel is at a weight ratio of 4 to 7:1. 
     
     
         28 . The method of  claim 26 , wherein the mixture is extracted with 60 to 80 (v/v) % of ethanol. 
     
     
         29 . A pharmaceutical composition comprising an extract of a mixture which comprises (i) mulberry and (ii)  Poria cocos  peel as an active ingredient. 
     
     
         30 . The pharmaceutical composition of  claim 29 , wherein the mixed extract of mulberry and  Poria cocos  peel is extracted with water, a lower alcohol having 1 to 4 carbon atoms, or a mixture thereof. 
     
     
         31 . The pharmaceutical of  claim 29 , wherein the mixed extract of mulberry and  Poria cocos  peel is extracted with 60 to 80 (v/v) % of ethanol.