Lipophilic active agent infused tobacco leaves and/or tobacco materials and methods of use thereof

Abstract

Aspects described herein relate to lipophilic active agent infused tobacco leaves and/or tobacco materials and methods of use thereof. More particularly, aspects described herein relate to tobacco leaves and/or tobacco materials infused with lipophilic active agents that provide enhanced bioavailability of the lipophilic active agents in a subject, and that mask unpleasant tastes.

1 .- 15 . (canceled) 
     
     
         16 . Nicotine infused tobacco leaves, comprising:
 (a) a therapeutically effective amount of nicotine;   (b) an edible oil; and   (c) tobacco leaves.   
     
     
         17 . The nicotine infused tobacco leaves according to  claim 16 , wherein the edible oil comprises one or more glycerol triesters, the triesters comprising medium chain (C 7 -C 13 ) or long chain (C 14 -C 22 ) fatty acids. 
     
     
         18 . The nicotine infused tobacco leaves according to  claim 16 , wherein the edible oil is a vegetable, nut, or seed oil. 
     
     
         19 . The nicotine infused tobacco leaves according to  claim 18 , wherein the edible oil is coconut oil, peanut oil, soybean oil, safflower seed oil, corn oil, olive oil, castor oil, cottonseed oil,  arachis  oil, sunflower seed oil, coconut oil, palm oil, or rapeseed oil. 
     
     
         20 . The nicotine infused tobacco leaves according to  claim 16 , wherein the edible oil is sunflower oil. 
     
     
         21 . The nicotine infused tobacco leaves according to  claim 16 , further comprising one or more cannabinoids. 
     
     
         22 . The nicotine infused tobacco leaves according to  claim 21 , further comprising THC or CBD. 
     
     
         23 . The nicotine infused tobacco leaves according to  claim 16 , further comprising a flavoring agent. 
     
     
         24 . The nicotine infused tobacco leaves according to  claim 23 , wherein the flavoring agent is selected from the group consisting of vanilla, vanillin, ethyl vanillin, orange oil, peppermint oil, strawberry, raspberry, and mixtures thereof. 
     
     
         25 . The nicotine infused tobacco leaves according to  claim 16 , wherein the tobacco leaves have been dehydrated. 
     
     
         26 . The nicotine infused tobacco leaves according to  claim 16 , wherein the nicotine infused tobacco leaves further comprise terpenes and terpenoids, NSAIDs, vitamins, phosphodiesterase type 5 (PDE5) inhibitors, Maca extract, estrogen, progestin, testosterone, buprenorphine, and scopolamine. 
     
     
         27 . A process for making nicotine infused tobacco leaves:
 (a) contacting tobacco leaves with an edible oil comprising nicotine; and   (b) dehydrating the tobacco leaves;   thereby producing nicotine infused tobacco.   
     
     
         28 . The process according to  claim 27 , wherein the nicotine tobacco leaves are dehydrated by lyophilization. 
     
     
         29 . The process according to  claim 27 , wherein the edible oil is a vegetable, nut, or seed oil. 
     
     
         30 . The process according to  claim 29 , wherein the edible oil is coconut oil, peanut oil, soybean oil, safflower seed oil, corn oil, olive oil, castor oil, cottonseed oil,  arachis  oil, sunflower seed oil, coconut oil, palm oil, or rapeseed oil. 
     
     
         31 . The process according to  claim 30 , wherein the edible oil is sunflower oil. 
     
     
         32 . The process according to  claim 27 , further comprising one or more cannabinoids. 
     
     
         33 . The process according to  claim 32 , wherein the one or more cannabinoids are THC or CBD. 
     
     
         34 . The process according to  claim 27 , wherein the nicotine infused tobacco leaves further comprise terpenes and terpenoids, NSAIDs, vitamins, phosphodiesterase type 5 (PDE5) inhibitors, Maca extract, estrogen, progestin, testosterone, buprenorphine, and scopolamine. 
     
     
         35 . The process according to  claim 27 , wherein the nicotine infused tobacco leaves further comprise a flavoring agent selected from the group consisting of vanilla, vanillin, ethyl vanillin, orange oil, peppermint oil, strawberry, raspberry, and mixtures thereof.