Transdermal delivery of pharmaceutical agents

Abstract

A method of administering a pharmaceutical agent to the circulatory system through the skin of a mammal may include the steps of loading a pharmaceutical agent in a transdermal patch, applying the transdermal patch to the skin of the mammal and releasing the pharmaceutical agent into the circulatory system at a rate of at least 0.001 micrograms per hour up to 50.0 micrograms per hour per kilogram of bodyweight of the mammal. The drug delivery system may comprise a transdermal patch loaded with the pharmaceutical agent. The patch may include a porous membrane and an outer impermeable cover defining a cavity therebetween. A plurality of drug delivery layers may be disposed between the porous membrane and the impermeable cover. A lipophilic/hydrophilic suspension may be disposed between the drug delivery layers.

1 . A method of administering a pharmaceutical agent through the skin of a mammal, comprising the steps of:
 a) loading said pharmaceutical agent in a transdermal patch;   b) applying said transdermal patch to the skin of the mammal;   c) releasing said pharmaceutical agent through the skin into the circulatory system of the mammal at a rate of at least 0.001 micrograms per hour up to 50.0 micrograms per hour per kilogram of bodyweight of the mammal.   
     
     
         2 . The method of  claim 1  wherein during the releasing step said pharmaceutical agent is released at a rate of 20 micrograms per hour per kilogram bodyweight of the mammal. 
     
     
         3 . The method of  claim 1  wherein said pharmaceutical agent comprises a pharmaceutical mixture of a liposomal prostaglandin, prostaglandin derivative, prostaglandin prodrug, or mixture thereof. 
     
     
         4 . The method of  claim 1  wherein said pharmaceutical agent comprises cannabis THC, cannabinols, prostaglandins or other lipophilic fatty acids in liposomal or raw form.