US2021308121A1PendingUtilityA1

Prmt5 inhibitors and uses thereof

77
Assignee: EPIZYME INCPriority: Dec 21, 2012Filed: Mar 2, 2021Published: Oct 7, 2021
Est. expiryDec 21, 2032(~6.4 yrs left)· nominal 20-yr term from priority
Inventors:Kenneth W. DuncanRichard ChesworthPaula Ann Boriack-SjodinMichael John MunchhofLei Jin
C07D 217/04A61P 35/00C07D 413/12C07D 217/12A61P 3/10C07D 401/14A61K 31/498Y02A50/30C07D 405/12A61P 3/04A61K 31/4725C07D 405/14A61K 31/538A61K 31/472C12N 9/1007C07D 401/12A61K 31/506A61K 31/496A61P 7/06A61K 31/5377
77
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

Claims

exact text as granted — not AI-modified
1 - 126 . (canceled) 
     
     
         127 . A method of treating breast cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         128 . The method of  claim 127 , comprising administering to the subject in need thereof a therapeutically effective amount of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         129 . The method of  claim 127 , comprising administering to the subject in need thereof a therapeutically effective amount of a pharmaceutically acceptable salt of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         130 . A method of treating myelodysplastic syndrome (MDS), comprising administering to a subject in need thereof a therapeutically effective amount of a compound: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         131 . The method of  claim 130 , comprising administering to the subject in need thereof a therapeutically effective amount of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         132 . The method of  claim 130 , comprising administering to the subject in need thereof a therapeutically effective amount of a pharmaceutically acceptable salt of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         133 . A method of treating acute myelocytic leukemia (AML), comprising administering to a subject in need thereof a therapeutically effective amount of a compound: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         134 . The method of  claim 133 , comprising administering to the subject in need thereof a therapeutically effective amount of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         135 . The method of  claim 133 , comprising administering to the subject in need thereof a therapeutically effective amount of a pharmaceutically acceptable salt of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         136 . A method of treating non-Hodgkin lymphoma (NHL), comprising administering to a subject in need thereof a therapeutically effective amount of a compound: 
       
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         137 . The method of  claim 136 , comprising administering to the subject in need thereof a therapeutically effective amount of the compound: 
       
         
           
           
               
               
           
         
       
     
     
         138 . The method of  claim 136 , comprising administering to the subject in need thereof a therapeutically effective amount of a pharmaceutically acceptable salt of the compound:

Join the waitlist — get patent alerts

Track US2021308121A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.