Composition comprising lactic acid bacteria for use in the preventive and/or curative treatment of recurrent cystitis

Abstract

A composition comprising lactic bacteria for use in the preventive and/or curative treatment of bacterial infections, which cause urinary tract and/or bladder inflammations is described. The composition is in particular for the treatment of recurrent cystitis.

1 . A method to treat bacterial infections caused by  E. coli  and/or related inflammations of the urinary tract and/or bladder in a subject, the method comprising:
 administering to the subject an effective amount of a composition comprising a mixture of bacteria, which comprises:
 a bacterial strain  Lactobacillus plantarum  LMG P-21020 (LP02); and 
 at least a strain of bacteria selected from the group comprising the strain  Lactobacillus paracasei  DSM 24243 (LPC09), the strain  Lactobacillus gasseri  DSM 18299 (LGS01), the strain  Lactobacillus gasseri  DSM 18300 (LGS02), the strain  Lactobacillus acidophilus  DSM 24303 (LA07) and the strain  Lactobacillus acidophilus  DSM 21717 (LA02). 
   
     
     
         2 . The method according to  claim 1 , wherein said mixture of bacteria further comprises  Lactobacillus plantarum  LMG P-21021 (LP01). 
     
     
         3 . The method according to  claim 1 , wherein said mixture of bacteria comprises  Lactobacillus plantarum  LMG P-21020 (LP02) and  Lactobacillus acidophilus  DSM 21717 (LA02). 
     
     
         4 . The method according to  claim 1 , wherein the infection and/or inflammation is cystitis. 
     
     
         5 . The method according to  claim 4 , wherein the cystitis is recurrent cystitis or uncomplicated acute cystitis. 
     
     
         6 . The method according to  claim 1 , wherein said composition further comprises a cranberry extract and/or a D-mannose. 
     
     
         7 . The method according to  claim 1 , wherein said composition further comprises a plant gum and/or a plant gelatin. 
     
     
         8 . The method according to  claim 1 , wherein said composition further comprises a fiber with prebiotic activity selected from inulin, fructo-oligosaccharides (FOS), galacto- and trans-galacto-oligosaccharides (GOS and TOS), gluco-oligosaccharides (GOSα), xylo-oligosaccharides, (XOS), chitosan-oligosaccharides (COS), soy-oligosaccharides (SOS), isomalto-oligosaccharides (IMOS), resistant starch, pectins, psyllium, arabino-galactans, gluco-mannans and galacto-mannans. 
     
     
         9 . (canceled) 
     
     
         10 . The method according to  claim 1 , wherein said composition comprises:
 (i) a mixture of bacteria which comprises  Lactobacillus plantarum  LMG P-21020 (LP02) and  Lactobacillus acidophilus  DSM 21717 (LA02),   (ii) a cranberry extract, a D-mannose and a guar gum, and   (iii) a fructo-oligosaccharide—FOS.   
     
     
         11 . (canceled) 
     
     
         12 . The method according to  claim 1 , wherein  Lactobacillus plantarum  LMG P-21020 (LP02) and the at least a strain of bacteria are in a weight ratio from 4:1 to 3:1. 
     
     
         13 . The method according to  claim 12 , wherein the weight ratio is 1:1. 
     
     
         14 . The method according to  claim 6 , wherein the cranberry extract is a dry cranberry extract. 
     
     
         15 . The method according to  claim 7 , wherein the plant gum and/or plant gelatin is selected from a tannate or a gelatin tannate, an alginate, a xyloglucan or xylogel, a guar gum, a tara gum, an acacia, carob, oat, bamboo fiber, citrus fruit fibers and glucomannans. 
     
     
         16 . The method according to  claim 8 , wherein the fiber with prebiotic activity is a short-chain FOS. 
     
     
         17 . The method according to  claim 10 , wherein the  Lactobacillus plantarum  LMG P-21020 (LP02) and the  Lactobacillus acidophilus  DSM 21717 (LA02) are in a weight ratio from 4:1 to 3:1, the cranberry extract, the D-mannose and the guar gum are in a weight ratio of 1:1:1 and the FOS and the cranberry extract are in a weight ratio of 5:1. 
     
     
         18 . The method according to  claim 10 , further comprising  Lactobacillus paracasei  DSM 24243 (LPC09). 
     
     
         19 . The method accordingly to  claim 18 , further comprising  Lactobacillus plantarum  LMG P-21021 (LP01). 
     
     
         20 . The method accordingly to  claim 19 , further comprising a muco-adhesive gelling complex comprised of exopolysaccharides (EPS) of bacterial origin produced by  Streptococcus thermophilus  ST10 DSM 25246 and tara gum. 
     
     
         21 . The method according to  claim 17 , wherein the  Lactobacillus plantarum  LMG P-21020 (LP02) and the  Lactobacillus acidophilus  DSM 21717 (LA02) are in a weight ratio of 1:1.