Endoxifen for the treatment of bipolar i disorder

Abstract

A method for managing or decreasing a risk of suicidal behaviour in a patient undergoing treatment of bipolar I disorder is provided. The said method includes maintaining the therapeutically effective concentration of endoxifen by administrating a dose of 2 mg to 16 mg of endoxifen citrate in an enteric coated tablet once per day for at least 21 days.

1 . A method for managing or decreasing a risk of suicidal behavior in a patient undergoing treatment of bipolar I disorder comprising:
 maintaining a therapeutically effective concentration of endoxifen in the patient by administrating a dose of 2 mg to 16 mg of endoxifen citrate in an enteric coated tablet once per day for at least 21 days.   
     
     
         2 . The method of  claim 1 , wherein the patient has manic episodes with mixed features. 
     
     
         3 . The method of  claim 1 , wherein the patient has manic episodes without mixed features. 
     
     
         4 . The method of  claim 1 , wherein the patient has depression. 
     
     
         5 . The method of  claim 1 , wherein the patient associated with depressive episodes. 
     
     
         6 . The method of  claim 1 , wherein the patient had the bipolar I disorder progress during or after treatment with at least one drug(s) selected from lithium, valproate, carbamazepine or an antipsychotic.