Dosing Regimen for Treatment of Cognitive and Motor Impairments with Blood Plasma and Blood Plasma Products

Abstract

Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.

1 . A method of treating a subject diagnosed with a cognitive impairment, the method comprising, administering an effective amount of a Plasma Fraction using a Pulse Dosed dosing regimen. 
     
     
         2 . The method of  claim 1  wherein the Plasma Fraction is a Plasma Protein Fraction. 
     
     
         3 . The method of  claim 2  wherein the Plasma Protein Fraction comprises between 83% to 95% albumin. 
     
     
         4 . The method of  claim 3  wherein the Plasma Protein Fraction is a commercially available Plasma Protein Fraction. 
     
     
         5 . The method of  claim 1  wherein the Plasma Fraction is a protein-enriched plasma protein product. 
     
     
         6 . The method of  claim 1  wherein the Plasma Fraction is derived from plasma from a pool of young individuals. 
     
     
         7 . The method of  claim 1  wherein the Plasma Fraction is produced from a mammalian blood product. 
     
     
         8 . The method of  claim 7  wherein the mammalian blood product is a human blood product. 
     
     
         9 . (canceled) 
     
     
         10 . The method of  claim 1  further comprising monitoring the subject for improved cognitive function. 
     
     
         11 . The method of  claim 1  wherein the subject is a mammal. 
     
     
         12 . The method of any  claim 11  wherein the mammal is a human. 
     
     
         13 . The method of  claim 1  wherein the Plasma Fraction or young plasma is derived from a pool of young individuals. 
     
     
         14 . The method of  claim 1  wherein the Pulse Dosed dosing regimen comprises administering the Plasma Fraction or young plasma for five to seven consecutive days. 
     
     
         15 . The method of  claim 1  wherein the effective amount is 100 ml. 
     
     
         16 . The method of  claim 1  wherein the effective amount is 250 ml. 
     
     
         17 . The method of  claim 1  wherein the subject follows an exercise regimen after the Pulsed Dosed dosing regimen has been fully administered. 
     
     
         18 . The method of  claim 1  wherein the administering increases the number of synapses in the subject. 
     
     
         19 . The method of  claim 1  wherein the administering increases synaptic integrity of the subject. 
     
     
         20 . The method of  claim 1  wherein the administering increases neuronal network integrity of the subject. 
     
     
         21 . The method of  claim 1  wherein the administering increases neuronal connectivity of the subject. 
     
     
         22 . A kit for use in treating a subject for a cognitive disorder, the kit comprising a container comprising a Plasma Fraction as described in  claim 1 .