Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders

Abstract

A nasally administered liquid, including suspension and viscous liquid compositions, containing a therapeutically effective quantity of (Z)-2-(3,5,5-trimethyl-2-cyclohexen-1-ylidene) acetic acid, its salts or analogs, combined with suitable pharmaceutical ingredients, to treat epilepsy.

What is claimed is: 
     
         1 . A method of treating epilepsy by a administering an effective amount of (Z)-2-(3,5,5-trimethyl-2-cyclohexen-1-ylidene) acetic acid, its salts or analogs, in a pharmaceutical formulation suitable essentially for nasal delivery. 
     
     
         2 . The method of treating epilepsy of  claim 1 , wherein the analog is (Z)-2-(3,5,5-trimethyl-2-cyclohexen-1-ylidene) acetic acid-Lys-Lys-OH. 
     
     
         3 . The method of treating epilepsy of  claim 1 , wherein the pharmaceutical formulation is a liquid, a suspension, a gel, an emulsion, or a cream. 
     
     
         4 . The method of treating epilepsy of  claim 1 , wherein the pharmaceutical formulation is comprised of a vegetable oil and a surfactant. 
     
     
         5 . The method of treating epilepsy of  claim 4 , wherein the vegetable oil is corn oil, sesame and olive oil, or a combination thereof. 
     
     
         6 . The liquid pharmaceutical composition of  claim 4 , wherein the surfactant is polysorbate 80.