High strength intraosseous implants

Abstract

The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

1 - 17 . (canceled) 
     
     
         18 . An intraosseous dental implant, comprising:
 a threaded endosseous dental device with a cylindrical shape and having an external thread extending from a root of the device along a helix angle with interspaces located between turns of the thread;   laser-grooved surfaces consisting of two parallel microgrooves at the interspaces between the thread turns and oriented according to the helix angle of said thread to provide a helix angle of the microgroves,   wherein said laser-grooved surfaces are coated with tresyl chloride coupled with fibronectin (FN),   wherein said laser-grooved surfaces are further coated with a nanofiber matrix (NFM), and   wherein, said NFM is adhered to said laser-grooved surfaces of said dental device, and aligned with the helix angle of said microgrooves   
     
     
         19 . The implant according to  claim 18 , wherein said microgrooves exhibit a capacity to hold 18 layers of nanofibers where microgroove depth is 5 μm. 
     
     
         20 . The implant according to  claim 19 , wherein said NFM comprises 18 fiber layers where said fibers are deposited circumferentially along the helix angle of said microgrooves and shielded from applied loads. 
     
     
         21 . The implant of  claim 18 , wherein said microgrooves are engraved to a depth of 5 μm, a width of 50 μm, and a spacing of 50 μm to 150 μm between said grooves at the interspace of said thread. 
     
     
         22 . The implant of  claim 18 , further comprising attached collagen loaded with silver nanoparticles (Ag NP) or antimicrobial analogs thereof. 
     
     
         23 . The implant of  claim 18 , wherein said nanofiber matrix (NFM) comprises at least one of growth factor or antibiotic-modified polycapronlectron (PCL) Electrospun Nanofibers (ENFs), said PCL-ENF combined with at least any of Platelet Derived Growth Factor (PDGF), Bone Morphogenetic Protein 2 (BMP2), PDGF+BMP2, or BMP2 and silver (Ag).