Devices for gastrointestinal stimulation and uses thereof

Abstract

A gastrointestinal stimulation devices including a random stimulation delivery mechanism(s), configured to provide stimuli to a bodily tissue in a vicinity of the stimulation capsule, the provided random stimuli being characterized by a stimulation parameter, and a control circuitry in communication with said physical stimulation delivery mechanism, and configured to set and alter the stimulation parameter non-systematically, thereby altering the characterization of the stimuli provided to the bodily tissue. The algorithm may be patient tailored, and may have a learning machinery which responds to data being received from the patient.

1 . A system for closed loop abdominal stimulation, comprising:
 an update module, computationally configured to receive a plurality of feature values, and provide stimulation parameters based thereon,   a sensor, configured to measure a physiological property, and provide a signal indicative thereof,   a stimulation device, comprising:
 a stimulation inducer, configured to generate a stimulation action based on stimulation parameters to affect a physiological change in a target organ or organs; and 
 a communication unit, configured to allow transfer of data to the stimulation device for modifying one or more stimulation parameters, and 
   wherein the update module comprises a processing circuitry, configured to:
 obtain a signal from said sensor; 
 determine stimulation parameters based on the signal obtained from said sensor; and 
 provide said stimulation device with the determined stimulation parameters via said communication unit, 
 wherein said processing circuitry of said update module is utilizing deep learning system, in which the learning on some features is guided learning, while learning on other features is unguided learning. 
   
     
     
         2 . The system of  claim 1 , wherein the stimulation is provided for achieving a desired physiological change. 
     
     
         3 . The system of  claim 1 , wherein the desired physiological change is a lowering of bodyweight, managing glucose levels, and/or lowering blood pressure. 
     
     
         4 . The system of  claim 1 , wherein the feature values are selected from a list comprising: age, weight, periodic caloric intake and output, gender, ethnicity, geography, pathological history/state, temperature, metabolic rate, glucose levels, blood tests and any physiological or pathological parameters that can be measured whether directly or indirectly associated with the physiological target. 
     
     
         5 . The system of  claim 1 , wherein said stimulation inducer is configured to affect a stimulation by providing a magnetic signal to a target body part, using various types of rate and rhythms of stimuli with various frequencies, amplitudes, durations, and interval, in structured or random manner. 
     
     
         6 . The system of  claim 1 , wherein said stimulation inducer is configured to affect a stimulation by physical movement, using various types of rate and rhythms of stimuli with various frequencies, amplitudes, durations, and interval, in structured or random manner. 
     
     
         7 . The system of  claim 1 , wherein said stimulation inducer is configured to affect a stimulation by electromagnetic signal emission, using various types of rate and rhythms of stimuli with various frequencies, amplitudes, durations, and interval, in structured or random manner. 
     
     
         8 . The system of  claim 1 , wherein said stimulation inducer is configured to affect a stimulation by temperature alteration, using various types of rate and rhythms of stimuli with various frequencies, amplitudes, durations, and interval, in structured or random manner. 
     
     
         9 . The system of  claim 1 , wherein said stimulation inducer is configured to affect a stimulation by including pressure, or using various types of rate and rhythms of stimuli with various frequencies, amplitudes, durations, and interval, in structured or random manner. 
     
     
         10 . The system of  claim 1 , wherein the sensor is configured to measure temperature, oxygen levels, blood pressure, and/or blood tests. 
     
     
         11 . A stimulation device for abdominal stimulation, comprising:
 a stimulation inducer, configured to generate a stimulation action based on stimulation parameters to affect a physiological change in a target region; and   a communication unit, configured to allow transfer of data between the stimulation device and an update module;   wherein the update module comprises a processing circuitry, configured to:
 obtain a signal from a sensor indicative of a physiological property; 
 determine stimulation parameters based on the signal obtain from said sensor; and 
 provide said stimulation device with the determined stimulation parameters via said communication unit, 
 wherein said processing circuitry of said update module is utilizing deep learning system, in which the learning on some features is guided learning, while learning on other features is unguided learning. 
   
     
     
         12 . The stimulation device of  claim 11 , having a form of a pill, configured to be swallowed or transplantable and reach a target body region within the digestive track. 
     
     
         13 . The stimulation device of  claim 11 , having a form of a wearable device, configured to be placed/held on/near a target body region. 
     
     
         14 . The stimulation device of  claim 11 , wherein said stimulation inducer is configured to affect a stimulation by providing a magnetic signal to a target body part, by physical movement, by electromagnetic signal emission, by temperature alteration, and/or by including pressure, or by any combination thereof. 
     
     
         15 . The stimulation device of  claim 11 , wherein the sensor is configured to measure, temperature, oxygen levels, pressure and/or body weight. 
     
     
         16 . A method for a continuous, semi-continuous, conditional, or non-continuous closed loop abdominal stimulation, comprising:
 providing/placing in a proximity of a target body part the stimulation device of  claim 11 ;   providing initial stimulation parameters to the stimulation device based on initial acquired information and a desired physiological change;   providing stimulation via the stimulation inducer based on the initial stimulation parameters; and   obtain information from the user and/or device or other sources, and update the stimulation parameters based on the obtained information.   
     
     
         17 . The method of  claim 16 , wherein the stimulation device is an implantable device. 
     
     
         18 . The method of  claim 16 , wherein the stimulation device is configured to be swallowed by a user. 
     
     
         19 . The method of  claim 16 , wherein the stimulation device is configured to be placed on the body of the user. 
     
     
         20 . The method  claim 16 , wherein the physiological change is a reduction of weight and/or maintaining a weight loss and wherein the method is for treatment of obesity, or any metabolic, inflammatory, infectious malignant condition.