Novel use of peptide for inhibiting functions and expressions of multiple disease biomarkers

Abstract

The present invention relates to a novel use of a peptide for inhibiting the functions and expressions of multiple disease biomarkers, and more specifically, to a pharmaceutical composition for treating or preventing inflammation, metabolic diseases or fibrotic diseases, the composition comprising, as an active ingredient, any one or more peptide among peptides which are represented by the amino acid sequences of SEQ ID NOs: 1 to 8, and which, for histone deacetylase 5 (HDAC5), GDF15 and ATF3 which are biomarkers associated with inflammation, metabolic diseases or fibrotic diseases, have the functions of inhibiting HDAC5 phosphorylation, inhibiting the expression of the GDF15 protein and inhibiting the expression of the ATF3 protein. The peptide, according to the present invention, enables the triple-blocking of the biomarkers associated with inflammation, metabolic diseases or fibrotic diseases by inhibiting HDAC phosphorylation, inhibiting the expression of the GDF15 protein and inhibiting the expression of the ATF3 protein, and thus the production of inflammatory cytokine may be reduced, and thus the peptide is effective in preventing and treating inflammatory, metabolic or fibrotic diseases.

1 . A method for treating or preventing an inflammatory, metabolic or fibrotic disease comprising administering a peptide represented by any one amino acid sequence selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 8 to a subject in need thereof. 
     
     
         2 . The method according to  claim 1 , wherein the disease is caused by hyperphosphorylation of HDAC5 protein, overexpression of GDF15 protein and/or overexpression of ATF3 protein. 
     
     
         3 . The method according to  claim 1 , wherein the peptide inhibits the phosphorylation of HDAC5 protein, the expression of GDF15 protein and/or the expression of ATF3 protein. 
     
     
         4 . The method according to  claim 1 , wherein the metabolic disease is at least one selected from the group consisting of arthritis, periodontitis, atopy, inflammatory colitis, ulcerative enteritis, Crohn's disease, hepatitis, fatty liver and obesity. 
     
     
         5 . The method according to  claim 4 , wherein the hepatitis is non-alcoholic steatohepatitis caused by diabetes and/or obesity. 
     
     
         6 . The method according to  claim 1 , wherein the fibrous disease is at least one selected from the group consisting of cirrhosis, pulmonary fibrosis, obstructive pulmonary disease, heart failure, arteriosclerosis, chronic kidney failure, diabetes, and keloids caused by postoperative sequelae. 
     
     
         7 . The method according to  claim 1 , wherein the peptide is prepared in any one formulation selected from the group consisting of injections, formulations for oral administration, patches, solutions, capsules, granules, tablets, powders, sprays, ointments, gels, mucosal formulations and suppositories. 
     
     
         8 . The method according to  claim 7 , wherein the formulation further comprises a pharmaceutically acceptable adjuvant. 
     
     
         9 . The method according to  claim 8 , wherein the pharmaceutically acceptable adjuvant comprises at least one selected from the group consisting of excipients, diluents, buffers, antimicrobial preservatives, surfactants, antioxidants, thickeners and viscosity modifiers. 
     
     
         10 . The method according to  claim 1 , wherein a daily dose of the peptide to be administered is 1 to 100 mg/kg and the peptide is administered once a day or 2 to 3 times a week.