Medicament delivery devices with wireless connectivity and event detection

Abstract

A computer-implemented method includes establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device. A user input selecting a motion profile of the medicament delivery device is then received in response to an input prompt. A wireless signal is received from the medicament delivery device, the wireless signal associated with an actual motion profile of the medicament delivery device. A notification is produced to indicate a motion difference between the actual motion profile and the target motion profile. In some embodiments, the method optionally includes modifying the target motion profile based on the motion profile over a time period of at least one week, the notification indicating a motion difference between the motion profile and the modified target motion profile.

1 . An apparatus, comprising:
 a medicament delivery device; and   an electronic circuit system coupled to at least one of a housing of the medicament delivery device or a cover configured to receive a portion of the medicament delivery device, the electronic circuit system including:
 a sensor configured to produce a motion signal associated with at least one of a position, a velocity, an acceleration, or an orientation of at least one of the housing or the cover; 
 a motion module implemented in at least one of a memory or a processing device, the motion module configured to receive the motion signal and determine, based on the motion signal, a motion profile associated with the medicament delivery device; and 
 a radio configured to electronically communicate with a computing device via a short-range wireless communication protocol, the radio sending a first wireless signal to establish a communications link between the computing device and the medicament delivery device, the radio sending a second wireless signal associated with the motion profile of the medicament delivery device. 
   
     
     
         2 . The apparatus of  claim 1 , wherein the medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler. 
     
     
         3 . The apparatus of  claim 1 , wherein the sensor is an accelerometer that detects at least one of the position, the velocity, the acceleration, or the orientation of at least one of the housing or the cover. 
     
     
         4 . The apparatus of  claim 1 , wherein the electronic circuit system further includes:
 a predictive module implemented in at least one of the memory or the processing device, the predictive module configured to determine a target motion profile based on the motion profile received over a time period; and   a notification module implemented in at least one of the memory or the processing device, the notification module configured to produce a notification signal indicating a motion difference between the motion profile and the target motion profile,   the radio sending a third wireless signal associated with the notification signal.   
     
     
         5 . The apparatus of  claim 1 , wherein:
 the motion profile is a daily motion profile; and   the time period is at least a month.   
     
     
         6 . A computer-implemented method, comprising:
 establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device, the medicament delivery device including a medicament container, an actuator, and an electronic circuit system, the actuator configured to initiate delivery of a medicament from the medicament container, the electronic circuit system including a first sensor, and a second sensor, the first sensor configured to produce a first actuation signal in response to movement of the actuator relative to the medicament container, the second sensor configured to produce a second actuation signal associated with a delivery characteristic of delivery of the medicament from the medicament container;   receiving, from the medicament delivery device, a first wireless signal associated with the first actuation signal;   receiving, from the medicament delivery device, a second wireless signal associated with the second actuation signal; and   producing an event detection notification based on the first wireless signal and the second wireless signal.   
     
     
         7 . The computer-implemented method of  claim 6 , wherein the delivery characteristic includes at least one of a vibration signature of the medicament delivery device during the second actuation, a gas pressure within the medicament delivery device during the second actuation, a temperature change of a portion of the medicament delivery device during the second actuation, or a noise produced by the medicament delivery device during the second actuation. 
     
     
         8 . The computer-implemented method of  claim 6 , wherein:
 the producing the event detection notification is performed in an event detection module and includes comparing information associated with the delivery characteristic conveyed via the second wireless signal to an actuation profile.   
     
     
         9 . The computer-implemented method of  claim 6 , wherein the delivery characteristic is associated with delivery of the medicament from the medicament container into a body, the delivery characteristic including at least one of a temperature associated with the body, an ionic change associated with placing the medicament delivery device in contact with the body, or a tissue impedance associated with the body. 
     
     
         10 . The computer-implemented method of  claim 6 , wherein the medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler. 
     
     
         11 . The computer-implemented method of  claim 8 , wherein the event detection notification indicates an actuation error when a time difference between an occurrence of the second actuation signal and an occurrence of the first actuation signal exceeds a time threshold. 
     
     
         12 . The computer-implemented method of  claim 6 , wherein the medicament delivery device includes a cover configured to be removably disposed about at least a portion of the actuator, and the electronic circuit system includes a third sensor configured to produce a removal signal in response to removal of the cover from about the portion of the actuator, the method further comprising:
 receiving, from the medicament delivery device, a third wireless signal associated with the removal signal, the producing the event detection notification performed only when the removal signal is produced before the first actuation signal.   
     
     
         13 . The computer-implemented method of  claim 6 , wherein the medicament delivery device includes a safety lock configured to limit movement of the actuator when in a first safety lock position, and the electronic circuit system includes a third sensor configured to produce a safety lock signal in response to movement of the safety lock from the first safety lock position to a second safety lock position, the method further comprising:
 receiving, from the medicament delivery device, a third wireless signal associated with the safety lock signal, the producing the event detection notification performed only when the safety lock signal is produced before the first actuation signal.   
     
     
         14 . The computer-implemented method of  claim 7 , wherein the electronic circuit system includes a third sensor configured to produce a third actuation signal associated with a bodily characteristic of a body within which the medicament is delivered, the method further comprising:
 receiving, from the medicament delivery device, a third wireless signal associated with the third actuation signal, the producing the event detection notification performed only when the third actuation signal associated with the bodily characteristic conveyed via the third wireless signal indicates that the medicament has been delivered into the body.   
     
     
         15 . An apparatus, comprising:
 a medicament delivery device including a housing, a medicament container at least partially contained within the housing, an actuator, and a safety member movably coupled to the housing, the safety member preventing movement of the actuator when the safety member is in a first position, the actuator being movable to actuate the medicament delivery device when the safety member is in a second position; and   an electronic circuit system coupled to at least one of a housing of the medicament delivery device or the safety member, the electronic circuit system including a processing device, an output device, a first sensor, a second sensor, and a power management module,   the electronic circuit system configured to produce a first electronic output via the output device when the first sensor produces a safety signal, the safety member configured to actuate the first sensor when the safety member is moved from the first position to the second position,   the electronic circuit system configured to produce a second electronic output when the second sensor produces an actuation signal, the actuator configured to actuate the second sensor when the actuator is moved,   the power management module implemented in at least one of a memory or the processing device, the power management module configured to modify the first electronic output when a number of times the safety member has actuated the first sensor exceeds a threshold safety member number.   
     
     
         16 . The apparatus of  claim 15 , wherein the power management module is configured to disable the production of the first electronic output when the number of times the safety member has actuated the first sensor exceeds the threshold safety member number. 
     
     
         17 . The apparatus of  claim 15 , wherein the output device is any one of an audible output device, a visual output device, a haptic output device, or a radio configured to electronically communicate with a computing device via a short-range wireless communication protocol. 
     
     
         18 . The apparatus of  claim 15 , wherein:
 the output device is an audible output device;   the first electronic output is a first recorded speech output having a first content; and   the power management module is configured to modify the first recorded speech output to include a second content when the number of times the safety member has actuated the first sensor exceeds the threshold safety member number, the second content less than the first content.   
     
     
         19 . The apparatus of  claim 15 , wherein:
 the electronic circuit system has a power source continuously electrically coupled to the processing device; and   the power management module determines the threshold safety member number based on at least one of a power level of the power source, a temperature of the medicament delivery device, or an expiration date of the medicament delivery device.   
     
     
         20 . The apparatus of  claim 15 , wherein:
 the medicament delivery device is any one of an auto-injector, a pen injector, a medication pump, a prefilled syringe, a nasal delivery device or an inhaler; and   the safety member is any one of a cap, a cover, a lid covering a portion of the medicament delivery device, or a safety lock engaged with the actuator.