Compositions and methods for improving bruising and rejuvenating skin

Abstract

Compositions and methods for improving bruising, stimulating elastin and/or collagen production, stimulating intrinsic hyaluronic acid production, stimulating adipogenesis, reducing inflammation, or combinations thereof are provided herein. Compositions and methods described herein may be used following a cosmetic procedure.

What we claim is: 
     
         1 . A topical composition for improving bruising associated with injection of a filler comprising:
 one or more ingredients encapsulated in a liposome;   a tripeptide; and   a hexapeptide,   wherein the topical composition improves healing or appearance of a bruise associated with injection of the filler.   
     
     
         2 . The topical composition of  claim 1 , wherein the tripeptide is tripeptide-1. 
     
     
         3 . The topical composition of  claim 2 , wherein the tripeptide-1 is present at 1-10 ppm. 
     
     
         4 . The topical composition of  claim 1 , wherein the hexapeptide is hexapeptide-12. 
     
     
         5 . The topical composition of  claim 4 , wherein the hexapeptide-12 is present at 1-10 ppm. 
     
     
         6 . The topical composition of  claim 1 , wherein a first ingredient of the one or more ingredients encapsulated in the liposome is hexapeptide-11. 
     
     
         7 . The topical composition of  claim 6 , wherein the hexapeptide-11 is present at 50-150 ppm. 
     
     
         8 . The topical composition of  claim 6 , wherein a second ingredient of the one or more ingredients encapsulated in the liposome is hexapeptide-38. 
     
     
         9 . The topical composition of  claim 8 , wherein the hexapeptide-38 is acetyl hexapeptide-38. 
     
     
         10 . The topical composition of  claim 1 , further comprising a tetrapeptide. 
     
     
         11 . The topical composition of  claim 10 , wherein the tetrapeptide is tetrapeptide-2. 
     
     
         12 . The topical composition of  claim 1 , further comprising phosphatidylserine. 
     
     
         13 . The topical composition of  claim 12 , wherein the phosphatidylserine is present at no more than 5.0 wt %. 
     
     
         14 . The topical composition of  claim 6 , wherein a third ingredient of the one or more ingredients encapsulated in the liposome is lactoferrin. 
     
     
         15 . The topical composition of  claim 14 , wherein the lactoferrin is present at no more than 5.0 wt %. 
     
     
         16 . The topical composition of  claim 1 , further comprising  Ledum palustre  extract, dill extract,  Tremella fuciformis  extract, butylene glycol, glycerin, squalane,  Dunaliella salina  extract, phospholipids, tocopherol, ascorbyl palmitate, xanthan gum, betaine, propanediol, lecithin, caprylic/capric triglyceride, caprylyl glycol, caprylyl methicone, phenoxyethanol, ethylhexylglycerin, polyacrylate-13, polyisobutene, polysorbate 20, caprylhydroxamic acid, disodium EDTA,  Arnica Montana  extract, sorbitan isostearate, pentylene glycol, glucose, sunflower seed oil, radish root ferment filtrate, potassium sorbate, sodium hyaluronate crosspolymer, xylitylglucoside, anhydroxylitol, xylitol, hydroxymethoxyphenyl decanone, or combinations thereof. 
     
     
         17 . A topical composition for rejuvenating skin comprising a liposome encapsulating:
 one or more peptides; and   lactoferrin,   wherein the topical composition rejuvenates skin.   
     
     
         18 . The topical composition of  claim 17 , wherein the one or more peptides comprises a tripeptide-1, a hexapeptide-12, a hexapeptide-11, a hexapeptide-38, a tetrapeptide-2, or combinations thereof. 
     
     
         19 . The topical composition of  claim 17 , further comprising phosphatidylserine. 
     
     
         20 . The topical composition of  claim 17 , further comprising  Ledum palustre  extract, dill extract,  Tremella fuciformis  extract, butylene glycol, glycerin, squalane,  Dunaliella salina  extract, phospholipids, tocopherol, ascorbyl palmitate, xanthan gum, betaine, propanediol, lecithin, caprylic/capric triglyceride, caprylyl glycol, caprylyl methicone, phenoxyethanol, ethylhexylglycerin, polyacrylate-13, polyisobutene, polysorbate 20, caprylhydroxamic acid, disodium EDTA,  Arnica Montana  extract, sorbitan isostearate, pentylene glycol, glucose, sunflower seed oil, radish root ferment filtrate, potassium sorbate, sodium hyaluronate crosspolymer, xylitylglucoside, anhydroxylitol, xylitol, hydroxymethoxyphenyl decanone, or combinations thereof.