US2021346663A1PendingUtilityA1

Methods for improving drug efficacy

Assignee: NUVAIRA INCPriority: Dec 27, 2012Filed: Dec 17, 2020Published: Nov 11, 2021
Est. expiryDec 27, 2032(~6.4 yrs left)· nominal 20-yr term from priority
Inventors:Martin L. Mayse
A61B 18/18A61K 31/573A61B 2018/00541A61B 2018/00577A61B 2018/0022A61B 18/1492A61N 1/3611A61K 31/522A61K 45/06A61K 31/00A61B 2018/00023A61K 31/56A61M 37/00A61K 31/137A61K 9/007A61B 17/32
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Claims

Abstract

The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.

Claims

exact text as granted — not AI-modified
1 . A method for improving efficacy of a drug in a patient having an obstructive lung disease, the drug having a reference efficacy, comprising:
 modulating nerve activity in the autonomic nervous system of the patient to reduce obstruction in at least one obstructed airway in the lung of the patient, and   subsequently administering the drug to the patient,   wherein steps (a) and (b) have a treatment efficacy greater than the reference efficacy.   
     
     
         2 .- 88 . (canceled)

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