Aqueous Preparation for External Use

Abstract

The purpose of the present invention is to provide an aqueous preparation for external use, said aqueous preparation comprising an acidic drug such as an arylacetic acid nonsteroidal anti-inflammatory analgesic, having an excellent percutaneous absorbability and giving a good feeling in use. The aqueous preparation for external use comprises the acidic drug or a salt thereof, isostearic acid and an alkanol amine. It is preferred that the aqueous preparation according to the present invention for external use further comprises a C2-6 aliphatic hydroxy acid and has a pH value of 4.5-7.8. The C2-6 aliphatic hydroxy acid is one member or a combination of the same selected from the group consisting of lactic acid, glycolic acid, malic acid, tartaric acid and citric acid.

1 - 5 . (canceled) 
     
     
         6 . An aqueous preparation for external use, comprising an acidic drug or a salt thereof, isostearic acid, an alkanolamine, isopropanol, and propylene glycol, wherein a weight ratio of isopropanol to propylene glycol is in a range of 1:3 to 3:1. 
     
     
         7 . The aqueous preparation according to  claim 6 , further comprising a C2-6 aliphatic hydroxy acid, and having pH 4.5 to 7.8. 
     
     
         8 . The aqueous preparation according to  claim 7 , wherein the C2-6 aliphatic hydroxy acid is one or more selected from the group consisting of lactic acid, glycolic acid, malic acid, tartaric acid and citric acid. 
     
     
         9 . The aqueous preparation according to  claim 6 , wherein the acidic drug is an arylacetic acid nonsteroidal anti-inflammatory analgetic. 
     
     
         10 . The aqueous preparation according to  claim 6 , further comprising glycerin.