Cannabis extracts

Abstract

A method is provided for removing THC from raw Cannabis oil. Additionally, new compositions of Cannabis oil are provided. Further, a new method of obtaining a substantially pure cannabinoid is provided

We claim: 
     
         1 . A method of removing one or more  Cannabis  compounds from a  Cannabis  oil, the method comprising:
 obtaining a column packed with a stationary phase particulate;   adding  Cannabis  oil to the packed column;   adding a first eluent to the packed column;   adding a second eluent to the packed column;   collecting at least two eluate fractions comprising one or more compounds; and   evaporating solvent from a subset of the at least two fractions to form a composition.   
     
     
         2 . The method of  claim 1 , further comprising adding a third eluent to the packed column. 
     
     
         3 . The method of  claim 1 , wherein the stationary phase particulate is selected from normal phase or reverse phase stationary phase. 
     
     
         4 . The method of  claim 3 , wherein the normal phase is silica gel stationary phase particulate. 
     
     
         5 . The method of  claim 3 , wherein the reverse phase is selected from the group consisting of C18, C8, C4 and phenyl stationary phase particulate. 
     
     
         6 . The method of  claim 4 , wherein the first eluent and second eluent are each solvents selected from one of, or a specific mixture of two or more of, the group consisting of petroleum ether, pentane, n-hexane, hexanes, n-heptane, heptanes, diethyl ether, methyl tert butyl ether, ethyl acetate, and ethanol. 
     
     
         7 . The method of  claim 6 , wherein the first eluent and the second eluent are each solvents selected from one of, or a specific mixture of two or more of, the group consisting of petroleum ether, n-hexane, hexanes, n-heptane, heptanes, diethyl ether, and methyl tert butyl ether. 
     
     
         8 . The method of  claim 6 , wherein the first eluent and the second eluent are each a mixture of diethyl ether and petroleum ether. 
     
     
         9 . The method of  claim 6 , wherein the first eluent and the second eluent are each a mixture of methyl tert butyl ether and petroleum ether. 
     
     
         10 . The method of  claim 6 , wherein the first eluent and the second eluent are each a mixture of diethyl ether and n-heptane or a heptane. 
     
     
         11 . The method of  claim 6 , wherein the first eluent and the second eluent are each a mixture of methyl tert butyl ether and n-heptane or a heptane. 
     
     
         12 . The method of  claim 4 , wherein the first eluent added totals between one and eleven column volumes (CVs), 2 to 7 CVs, or 4 to 6 CVs. 
     
     
         13 . The method of  claim 4 , wherein the second eluent added totals between one and eleven column volumes (CVs), 2 to 7 CVs, or 4 to 6 CVs. 
     
     
         14 . The method of  claim 1 , the method further comprises pooling the eluate from 6-7.5 CVs, evaporating the pooled eluate, and recrystallizing the composition to provide a purified composition comprising cannabidiol (CBD) in greater than 94% purity, having not more than 0.3% THC. 
     
     
         15 . The method of  claim 1 , wherein the composition comprises 60-70% CBD, not more than 0.3% THC, 0.3-5% CBC, and about 10-20% fatty acids and terpenes. 
     
     
         16 . A method for processing raw  Cannabis  oil to provide clean  Cannabis  oil having less than 0.3 wt % delta9-THC, the method comprising:
 obtaining raw  Cannabis  oil;   applying the raw  Cannabis  oil to a normal stationary phase column;   eluting the normal stationary phase column with a binary solvent system wherein the binary solvent system comprises a first solvent A and a second solvent B;   fractionating the eluate into at least two eluate fractions; and   evaporating solvent from a subset of the at least two eluate fractions to provide the clean  Cannabis  oil comprising less than 0.3 wt % THC.   
     
     
         17 . The method of  claim 16 , wherein the first solvent A in the binary solvent system is a non-polar solvent selected from one or more of the group consisting of pentane, petroleum ether, hexanes, n-hexane, n-heptane, heptanes, diisopropyl ether, toluene, chloroform, and methylene chloride. 
     
     
         18 . The method of  claim 16 , wherein the second solvent B in the binary solvent system is a polar solvent selected from one or more of the group consisting of diethyl ether, methyl tert butyl ether, tetrahydrofuran, ethyl acetate, acetone, acetonitrile, isopropanol, ethanol, and methanol. 
     
     
         19 . The method of  claim 16 , wherein the column is eluted with a step gradient using a binary solvent system comprising the first solvent A and the second solvent B, wherein solvent A is petroleum ether, a heptane, or n-heptane and solvent B is diethyl ether or methyl tert butyl ether. 
     
     
         20 . A composition comprising about 65-70% CBD, not more than 0.3% THC, 0.3-5% CBC, 0.3-5% CBG, 0.3-5% CBN, and about 10-20% fatty acids and terpenes.