Antiperspirant

Abstract

Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I):and derivatives thereof, and compounds represented by formula (VII):and derivatives thereof.

1 . An antiperspirant for suppressing the secretion of sweat, which comprises as an active ingredient for suppressing the secretion of sweat, a pentacyclic compound represented by the formula (I): 
       
         
           
           
               
               
           
         
         wherein R 1  is a group represented by the formula (II): 
       
       
         
           
           
               
               
           
         
         
           wherein R 2  is hydrogen atom, hydroxyl group, an alkoxy group having 1 to 12 carbon atoms which may have a substituent, an alkanoyl group having 1 to 12 carbon atoms which may have a substituent, an alkanoyloxy group having 1 to 12 carbon atoms which may have a substituent, or glucopyranosyloxy group which may have a substituent, or 
         
         a group represented by the formula (III): 
       
       
         
           
           
               
               
           
         
         R 3  is hydrogen atom or hydroxyl group; R 4  is the group represented by the formula (III) or a group represented by the formula (IV): 
       
       
         
           
           
               
               
           
         
         
           wherein R 5  is hydrogen atom, a halogen atom, hydroxyl group, or an alkyl group having 1 to 6 carbon atoms; 
         
         R 6  is the group represented by the formula (III) or a group represented by the formula (V): 
       
       
         
           
           
               
               
           
         
         
           wherein R 7  is hydrogen atom, hydroxyl group or an alkyl group having 1 to 6 carbon atoms; 
         
         each of R 8  and R 9  is independently hydrogen atom, hydroxyl group or an alkyl group having 1 to 6 carbon atoms; R 10  is an alkyl group having 1 to 6 carbon atoms or carboxyl group; R 11  is hydrogen atom, hydroxyl group, an alkyl group having 1 to 6 carbon atoms or carboxyl group; R 12  is hydrogen atom, an alkyl group having 1 to 6 carbon atoms or carboxyl group; R 13  is hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and R 14  is the group represented by the formula (III) or a group represented by the formula (VI): 
       
       
         
           
           
               
               
           
         
         a derivative of the pentacyclic compound represented by the formula (I); a pentacyclic compound represented by the formula (VII): 
       
       
         
           
           
               
               
           
         
         wherein each of R 1 , R 6 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13  and R 14  is the same as defined above, and R 15  is hydrogen atom, a halogen atom or hydroxyl group; and 
         a derivative of the pentacyclic compound represented by the formula (VII). 
       
     
     
         2 . The antiperspirant according to  claim 1 , wherein R 1  is a group represented by formula (II). 
     
     
         3 . The antiperspirant according to  claim 2 , wherein R 2  in formula (II) is hydroxy group, an alkanoyloxy group having 1 to 12 carbon atoms which may have a substituent, or glucopyranosyloxy group which may have a substituent. 
     
     
         4 . The antiperspirant according to  claim 2 , wherein R 2  in formula (II) is hydroxyl group, an alkanoyloxy group of 1 to 12 carbon atoms having carboxyl group as a substituent, or a glucopyranosyloxy group having glucopyranolofuranosyl group as a substituent. 
     
     
         5 . The antiperspirant according to  claim 1 , wherein R 3  is hydrogen atom. 
     
     
         6 . The antiperspirant according to  claim 1 , wherein R 4  is a group represented by formula (III). 
     
     
         7 . The antiperspirant according to  claim 1 , wherein R 4  is a group represented by formula (IV). 
     
     
         8 . The antiperspirant according to  claim 1 , wherein R 5  in the group represented by formula (IV) is hydrogen atom. 
     
     
         9 . The antiperspirant according to  claim 1 , wherein R 6  is a group represented by formula (III). 
     
     
         10 . The antiperspirant according to  claim 1 , wherein R 6  is a group represented by formula (V).