Formulations of abaloparatide, transdermal patches thereof, and uses thereof

Abstract

Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.

1 . A preparation formulation suitable for coating a transdermal patch wherein said preparation formulation comprises abaloparatide, water and one or more excipients selected from the group consisting of Zn 2+  salts, Mg 2+  salts, Ca 2+  salts, polyethylene glycols and hydroxypropyl beta-cyclodextrins. 
     
     
         2 - 66 . (canceled)