Compounds

Abstract

Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.

1 . An isolated binding member for human IL-6, which binds human IL-6 with a K D  of not more than 30 pM as defined by surface plasmon resonance. 
     
     
         2 - 22 . (canceled) 
     
     
         23 . An isolated binding member for human IL-6, comprising an HCDR3, an LCDR3 and/or a set of CDRs of any of antibodies 2, 3, 4, 5, 7, 8, 10, 14, 16, 17, 18, 19, 21, 22 or 23. 
     
     
         24 - 58 . (canceled) 
     
     
         59 . A method for producing an antibody antigen-binding domain for IL-6, the method comprising
 providing, by way of addition, deletion, substitution or insertion of one or more amino acids in the amino acid sequence of a parent VH domain comprising HCDR1, HCDR2 and HCDR3, wherein the parent VH domain HCDR1, HCDR2 and HCDR3 are a set of HCDRs as shown in Table 7, a VH domain which is an amino acid sequence variant of the parent VH domain, and optionally combining the VH domain thus provided with one or more VL domains to provide one or more VH/VL combinations; and   testing said VH domain which is an amino acid sequence variant of the parent VH domain or the VH/VL combination or combinations to identify an antibody antigen binding domain for IL-6.   
     
     
         60 - 73 . (canceled)