Predictive deep learning for enhancement of specimen workflow

Abstract

The present disclosure provides methods for screening subjects at a subordinate location within a geographic region, or a subordinate space within the subordinate location for an infectious agent. Such methods may comprise assigning a risk score to each of the one or more subordinate locations or subordinate spaces based on an amount of infectious agent in pooled environmental samples and pooled biological samples in a subordinate location or subordinate space as compared to each other subordinate location or subordinate space, and then screening biological samples from subordinate locations or subordinate spaces that have a higher risk score before screening biological samples from subordinate locations or subordinate spaces that have a lower risk score. Methods for determining a risk of a viral infection in one or more geographic regions are also provided.

1 - 22 . (canceled) 
     
     
         23 . A method of regulating a risk of an infection with an infectious agent for a subject, the method comprising,
 a. generating a heat map of the amount of infectious agent at one or more subordinate locations within the geographic region, wherein the heat map is generated by:
 i) pooling air samples at a pooling ratio of about 2:1 to about 100:1 obtained within each of the one or more subordinate locations; 
 ii) measuring an amount of the infectious agent in the pooled air samples for each of the one or more subordinate locations, and
 iii) assigning each of the one or more subordinate locations or the subject that resides in or passed through the subordinate location a risk score based on the amount of infectious agent in the pooled air samples in each of the one or more subordinate locations as compared to each other subordinate location; and 
 
   b. determining the risk of infection with the infectious agent for the subject based on the risk score assigned to the subordinate location that the subject resides in or passed through.   
     
     
         24 . The method of  claim 23 , wherein the heat map provides an exposure pathway for an infectious agent. 
     
     
         25 . The method of  claim 23 , wherein the infectious agent is a virus or a bacterium. 
     
     
         26 . The method of  claim 25 , wherein the virus is SARS-CoV-2. 
     
     
         27 . The method of  claim 23 , wherein the geographic region is a country, state, county, city, or neighborhood. 
     
     
         28 . The method of  claim 23 , wherein the one or more subordinate locations include one or more counties, cities, or city blocks. 
     
     
         29 . The method  claim 23 , wherein the one or more subordinate locations are a city block, multiple city blocks, a house(s) or a building(s). 
     
     
         30 . The method of  claim 23 , wherein environmental and/or biological samples are pooled from 10-100 subordinate locations or subordinate spaces. 
     
     
         31 . A non-transitory machine-readable storage medium comprising machine-readable instructions for causing a processor to execute the method of  claim 23 . 
     
     
         32 . A system for regulating the risk of an infection comprising:
 a memory configured to store instructions; and   one or more processors configured to execute one or more instructions stored in the memory to perform the method of  claim 23 .