Method for preventing or treating heart failure by administering a medicament containing an antagonist of corticotropin releasing hormone receptor 2 (crhr2)

Abstract

A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient.

1 - 7 . (canceled) 
     
     
         8 . A medicament for preventing or treating heart failure containing an antagonist of the corticotropin releasing hormone receptor 2 as an active ingredient. 
     
     
         9 . The medicament according to  claim 8 , wherein the heart failure is chronic heart failure. 
     
     
         10 . A pharmaceutical composition for preventing or treating heart failure in a mammal comprising an effective amount of the medicament according to  claim 8 . 
     
     
         11 . The pharmaceutical composition according to  claim 10 , further comprising at least one of pharmaceutically acceptable carriers, diluents and excipients. 
     
     
         12 . A method for selecting a subject effective for treatment with the medicament according to  claim 8 , comprising the steps of:
 measuring the serum concentration of the corticotropin releasing hormone receptor 2 agonist in a subject; and   selecting a subject whose measured value is higher than the reference value.   
     
     
         13 . A method of screening drugs for preventing or treating heart failure, comprising the steps of:
 selecting a test substance capable of inhibiting the binding of a corticotropin releasing hormone receptor 2 to its ligand; or   selecting a test substance capable of inhibiting the intracellular signal transduction caused by the binding of a corticotropin releasing hormone receptor 2 to its ligand.