Potassium channel modulators

Abstract

Provided are compounds and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.

1 . A compound of the formula: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         2 . A pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. 
     
     
         3 . A method of treating a disease or condition responsive to modulation of the small conductance calcium-activated potassium channel (SK channel) in a subject in need thereof comprising the step of administering a compound of  claim 1  to the subject, or a pharmaceutically acceptable salt thereof, or the composition of  claim 2 . 
     
     
         4 . The method of  claim 3 , wherein the disease or condition is response to the modulation of the SK2 channel. 
     
     
         5 . The method of  claim 3 , wherein the disease or condition is selected from a neurodegenerative disease, dementia, heart disease, withdrawal symptoms associated with termination of addiction, metabolic disease, and bladder disease. 
     
     
         6 . The method of  claim 3 , wherein the disease or condition is selected from ataxia, dystonia, tremors, Parkinson's disease, ischemia, traumatic brain injury, amyotrophic lateral sclerosis, hypertension, atherosclerosis, diabetes, arrhythmia, over-active bladder, and withdrawal symptoms caused by the termination of abuse of alcohol and other drugs of abuse. 
     
     
         7 . The method of  claim 6 , wherein the disease or condition is essential tremor. 
     
     
         8 . The method of  claim 6 , wherein the disease or condition is ataxia. 
     
     
         9 . The method of  claim 8 , wherein the disease or condition is spinocerebellar ataxia.