Compositions, methods and systems for the treatment of cutaneous disorders

Abstract

Provided herein are devices, systems, kits and methods for treating skin conditions, ailments or diseases, such as skin warts. In some examples, a device for treating warts comprises a reservoir that includes a cantharidin formulation, and an applicator device in fluid communication with the reservoir that delivers the cantharidin formulation to a subject.

1 - 76 . (canceled) 
     
     
         77 . A formulation comprising:
 cantharidin;   acetone;   ethanol;   a film-forming agent; and   a gelling agent;   wherein the formulation comprises 5% (w/v) or less of diethyl ether.   
     
     
         78 . The formulation of  claim 77 , wherein the formulation comprises 1% (w/v) or less of diethyl ether. 
     
     
         79 . The formulation of  claim 77 , wherein the formulation is substantially free of diethyl ether. 
     
     
         80 . The formulation of  claim 77 , wherein the gelling agent is selected from the group consisting of dextran, hydroxypropyl cellulose, and ethyl cellulose. 
     
     
         81 . The formulation of  claim 77 , wherein the film-forming agent is selected from the group consisting of nitrocellulose, polyvinyl pyrrolidone, hydroxypropylmethyl cellulose, and carboxymethyl cellulose. 
     
     
         82 . The formulation of  claim 77  further comprising one or more plasticizers. 
     
     
         83 . The formulation of  claim 82 , wherein the one or more plasticizers comprise camphor and/or castor oil. 
     
     
         84 . The formulation of  claim 77  further comprising a flavorant that induces a bitter taste to prevent or deter licking and/or ingestion of the formulation by a subject. 
     
     
         85 . The formulation of  claim 84 , wherein the flavorant is selected from the group consisting of denatonium, amarogentin, gentiopicrin, sucrose octaacetate, quercetin, brucine, and quassin. 
     
     
         86 . The formulation of  claim 77  further comprising a colorant that enables visible detection of the formulation by the subject. 
     
     
         87 . The formulation of  claim 86 , wherein the colorant is selected from the group consisting of D&C violet, isosulfan blue, methylene blue, methyl red, methyl orange, congo red, alizarin yellow, bromocresol green, and gentian violet. 
     
     
         88 . The formulation of  claim 77 , wherein the formulation has a viscosity of more than 5 centipoise and less than 100 centipoise. 
     
     
         89 . The formulation of  claim 77 , wherein the formulation comprises 55% (w/v) or more of acetone; and 30% (w/v) or more of ethanol. 
     
     
         90 . The formulation of  claim 77 , comprising:
 cantharidin;   acetone;   ethanol;   nitrocellulose; and   hydroxypropyl cellulose.   
     
     
         91 . The formulation of  claim 90  further comprising camphor and castor oil. 
     
     
         92 . The formulation of  claim 91  further comprising denatonium benzoate and/or gentian violet 
     
     
         93 . A formulation comprising:
 cantharidin;   hydroxypropyl cellulose;   nitrocellulose; and   one or more solvents;   wherein the formulation comprises 5% (w/v) or less of diethyl ether.   
     
     
         94 . The formulation of  claim 93 , wherein the formulation comprises 1% (w/v) or less of diethyl ether. 
     
     
         95 . The formulation of  claim 93 , wherein the formulation is substantially free of diethyl ether. 
     
     
         96 . A formulation comprising:
 cantharidin in amount from 0.001-7% (w/v);   ethanol in an amount up to 99% (w/v);   acetone in an amount up to 99% (w/v);   hydroxypropyl cellulose in an amount up to 10% (w/v);   nitrocellulose in an amount up to 10% (w/v);   castor oil in an amount up to 5% (w/v); and   camphor in an amount up to 5% (w/v).   
     
     
         97 . The formulation of  claim 96  further comprising:
 denatonium benzoate in an amount from 0.00001-1% (w/v); and/or 
 gentian violet in an amount from 0.00001-1% (w/v). 
 
     
     
         98 . A method of treating a subject having a skin lesion comprising administering a composition of  claim 77  to at least a portion of the skin lesion. 
     
     
         99 . The method of  claim 98 , wherein the skin lesion is caused by molluscum contagiosum. 
     
     
         100 . An applicator device for delivering a cantharidin formulation to a subject comprising:
 a reservoir comprising a cavity containing a cantharidin formulation of  claim 77 ; and   an applicator unit in fluid communication with the reservoir.