Oxidized cardiolipin as a pro-inflammatory factor

Abstract

Low levels of antibodies reactive with oxidised Cardiolipin (oxCL) in mammals are related to an increased risk of developing cardivacular diseases, auto-immune diseases or inflammatory conditions. High levels can have a protective function and in general there is a negative association between manifestations of these conditions and antibodies against oxCL. Thus, based on their relations methods of monitoring, determining and diagnosing as well as methods of immunisation and therapy of these diseases and conditions are provided.

1 - 14 . (canceled) 
     
     
         15 . A method of treating, or reducing the risk of developing, an acute inflammatory condition in a mammal, comprising administering to the mammal in need thereof a therapeutically effective amount of Annexin A5. 
     
     
         16 . The method according to  claim 15 , wherein the mammal is selecting from the list consisting of: a mouse, a rat, a rabbit, a dog, a cat, cattle, a horse, and a human. 
     
     
         17 . The method according to  claim 16 , wherein the mammal is a human.