Implantable medical devices with increased immune tolerance, and methods for making and implanting

Abstract

The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).

1 - 87 . (canceled) 
     
     
         88 . A medical device coated with DA-DKP and a component selected from the group consisting of N-acetyl tryptophan, caprylate, caprylic acid, and combinations thereof. 
     
     
         89 . The medical device of  claim 88 , wherein the component is N-acetyl tryptophan. 
     
     
         90 . The medical device of  claim 88 , wherein the component is caprylate, caprylic acid, or both caprylate and caprylic acid. 
     
     
         91 . The medical device of  claim 88 , wherein the component is N-acetyl tryptophan and caprylate. 
     
     
         92 . The medical device of  claim 88 , wherein the component is N-acetyl tryptophan and caprylic acid. 
     
     
         93 . The medical device of  claim 88 , wherein the component is N-acetyl tryptophan, caprylate and caprylic acid. 
     
     
         94 . The medical device of  claim 88 , which is implantable. 
     
     
         95 . The medical device of  claim 88 , which is selected from the group consisting of a graft, catheter, stent, prosthetic, breast implant, pump, tube, pin, rod, screw, brace, plate and pacemaker. 
     
     
         96 . The medical device of  claim 88 , which is a tracheal tube. 
     
     
         97 . The medical device of  claim 96 , which is an endotracheal tube. 
     
     
         98 . A method of preparing a medical device, comprising contacting the medical device with DA-DKP and a component selected from the group consisting of N-acetyl tryptophan, caprylate, caprylic acid, and combinations thereof. 
     
     
         99 . The method of  claim 98 , wherein the component is N-acetyl tryptophan. 
     
     
         100 . The method of  claim 98 , wherein the component is caprylate, caprylic acid, or both caprylate and caprylic acid. 
     
     
         101 . The method of  claim 98 , wherein the component is N-acetyl tryptophan and caprylate or N-acetyl tryptophan and caprylic acid. 
     
     
         102 . The method of  claim 98 , wherein the device is implantable. 
     
     
         103 . The method of  claim 98 , wherein the device is selected from the group consisting of a graft, catheter, stent, prosthetic, breast implant, pump, tube, pin, rod, screw, brace, plate and pacemaker. 
     
     
         104 . The method of  claim 98 , wherein the device is a tracheal tube. 
     
     
         105 . The method of  claim 104 , wherein the device is an endotracheal tube. 
     
     
         106 . The method of  claim 98 , wherein the DA-DKP is coated onto the surface of the device. 
     
     
         107 . A method for implanting a medical device into a subject, wherein a surface of the device is coated with DA-DKP, N-acetyl tryptophan, caprylate, caprylic acid, or combinations thereof.