Hydroxyl compounds and compositions for cholesterol management and related uses

Abstract

The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

1 .- 15 . (canceled) 
     
     
         16 . A method of lowering LDL cholesterol in a human, comprising administering orally to a human in need of such treatment a therapeutically effective amount of a compound represented by: 
       
         
           
           
               
               
           
         
       
     
     
         17 . The method of  claim 16 , wherein the compound is administered orally to the human in the form of a pharmaceutical composition comprising the compound, and a pharmaceutically acceptable vehicle. 
     
     
         18 . The method of  claim 16 , wherein the human has familial hypercholesterolemia. 
     
     
         19 . The method of  claim 16 , wherein the human has cardiovascular disease. 
     
     
         20 . The method of  claim 19 , wherein the cardiovascular disease is atherosclerotic cardiovascular disease. 
     
     
         21 . The method of  claim 17 , wherein the human has familial hypercholesterolemia. 
     
     
         22 . The method of  claim 17 , wherein the human has cardiovascular disease. 
     
     
         23 . The method of  claim 22 , wherein the cardiovascular disease is atherosclerotic cardiovascular disease.