Methods and compositions for treating conditions associated with an abnormal inflammatory responses

Abstract

This disclosure features chemical entities (e.g., a compound exhibiting activity as a mitochondrial uncoupling agent or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof; e.g., a compound, such as niclosamide or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof; e.g., a compound, such as a niclosamide analog, or a pharmaceutically acceptable salt and/or hydrate and/or cocrystal thereof) that are useful, e.g., for treating one or more symptoms of a pathology characterized by an abnormal inflammatory response (e.g., inflammatory bowel diseases) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

What is claimed is: 
     
         1 . A method for inducing cell death of one or more T cells in the gastrointestinal tract (GI) of a subject, the method comprising contacting the one or more T cells with an effective amount of a mitochondrial uncoupling agent or a pharmaceutically acceptable salt and/or hydrate thereof.