Device and method for aerosolized delivering of substance to a natural orifice of the body

Abstract

A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

1 . A device for delivering a predetermined volume V sub  [ml] of at least one substance within at least one body cavity of a subject, said device comprising:
 a. at least one capsule sized and shaped for containing said predetermined volume V sub  [ml] of said at least one substance; wherein said predetermined volume V sub  [ml] is in a range of 0.01-7 ml;   b. a nozzle configured for placement in proximity to said at least one body cavity, said nozzle being in fluid communication with said at least one capsule; said nozzle comprises at least one orifice, wherein a diameter D [mm] of the at least one orifice is in a range of 0.2-6 mm;   c. at least one valve mechanically connectable to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of the predetermined volume V sub  [ml] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined volume V sub  [ml] of said at least one substance from said at least one capsule to said at least one body cavity;
 said at least one valve is reconfigurable from said inactive configuration to said active configuration within a predetermined period of time, dT, in response to activation of said at least one valve; wherein said predetermined period of time dT is less than or equal to 200 ms; and 
   d. a fluid tight chamber configured to contain predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg]; wherein said predetermined pressure P gas  [barg] is in a range of 1-10 barg;   said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, is configured to entrain said at least one substance and deliver said at least one substance via said at least one orifice in said nozzle within said at least one body cavity;   wherein said device is configured to deliver said predetermined volume V sub  [ml] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said predetermined volume V sub  [ml] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas, dT deliver , is less than 500 milliseconds; and   wherein the dT deliver  is maintained less than 500 milliseconds independent of the predetermined volume V gas  [ml], V sub  [ml], and the predetermined pressure, P gas  [barg].   
     
     
         2 . The device of  claim 1 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         3 . The device of  claim 1 , wherein at least one of the following is true:
 a. said at least one body cavity is selected from a group consisting of a nasal cavity, a mouth, a throat, an ear, a vagina, a rectum, a urethra, and any combination thereof;   b. a viscosity η of said at least one substance is in a range of 1×10 −3  poise to 1 poise;   c. a velocity of said particles of said at least one substance, after exit from said device, is in a range of about 5 m/s to 50 m/s;   d. said pressurized gas comprises at least one of air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon or any combination thereof;   e. during dispensing of said at least one substance, a mixture of said predetermined volume V gas  [ml] of said pressurized gas with said predetermined volume V sub  [ml] of said at least one substance entrained within it forms a plume of aerosol; said aerosol having a predetermined distribution, said distribution being either homogeneous or heterogeneous, said heterogeneous distribution is selected from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; characteristics of said aerosol selected from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof;   f. said at least one substance is selected from a group consisting of a gas, a liquid, a powder, an aerosol, a slurry, a gel, a suspension and any combination thereof;   g. said at least one substance is stored under either an inert atmosphere or under vacuum to prevent reaction during storage;   h. a dose-response curve is substantially linear for a brain concentration of said at least one substance when administered nasally via said device; and   i. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof; of said at least one substance when administered nasally via said device.   
     
     
         4 . The device of  claim 1 , wherein said at least one capsule has a main longitudinal axis, said at least one capsule comprising a number n of compartments, said at least one capsule configured to contain said predetermined volume V sub  [ml] of said at least one substance, said predetermined volume V sub  [ml] of said at least one substance containable in at least one of said n compartments; at least one of the following being true:
 a. the number n of said compartments is an integer greater than or equal to 1; said compartments being annular; at least one of said compartments has a cross-section with a shape selected from a group consisting of: circular, oval, elliptical, polygonal and any combination thereof;   b. for said number n of compartments being an integer greater than 1, at least two said compartments have different volumes;   c. for said number n of compartments being an integer greater than 1, at least two said compartments have the same volume;   d. for said number n of compartments being an integer greater than 1, at least two said compartments have different cross-sectional areas;   e. for said number n of compartments being an integer greater than 1, at least two said compartments have the same cross-sectional area;   f. for said number n of compartments being an integer greater than 1, at least two said compartments contain different substances;   g. for said number n of compartments being an integer greater than 1, at least two said compartments contain the same substance;   h. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed coaxially around said main longitudinal axis of said at least one capsule;   i. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed sequentially along said main longitudinal axis of said at least one capsule;   j. for said number n of compartments greater than 1, there is mixing of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during dispensing; and   k. for said number n of compartments greater than 1, there is a reaction of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during said dispensing.   
     
     
         5 . The device of  claim 1 , wherein said at least one capsule comprises a port fluidly connectable to the exterior of said device, said port configured such that said at least one substance is insertable into said capsule via said port. 
     
     
         6 . The device of  claim 5 , wherein said device comprises a port cover configured to provide an air-tight closure for said port, said port cover selected from a group consisting of slidable along said device, rotatable around said device, rotatable around a hinge on an exterior of said device and any combination thereof. 
     
     
         7 . A device for delivering a predetermined mass M sub  [mg] of at least one substance within at least one body cavity of a subject, said device comprising:
 a. at least one capsule sized and shaped for containing said predetermined mass M sub  [mg] of said at least one substance; wherein said predetermined mass M sub  [mg] is in a range of 1-1000 mg;   b. a nozzle configured for placement in proximity to said at least one body cavity, said nozzle being in fluid communication with said at least one capsule; said nozzle comprising at least one orifice, wherein a diameter D [mm] of the at least one orifice is in a range of 0.2-6 mm;   c. at least one valve mechanically connectable to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of said predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity,
 said at least one valve is reconfigurable from said inactive configuration to said active configuration within a predetermined period of time, dT, in response to activation of said at least one valve; wherein said predetermined period of time dT is less than or equal to 200 ms and 
   d. a fluid tight chamber configured to contain said predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg]; wherein said predetermined pressure P gas  is in a range of 1-10 barg;   said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, is configured to entrain said at least one substance and deliver said at least one substance via said at least one orifice in said nozzle within said at least one body cavity;   wherein said device is configured to deliver said predetermined mass M sub  [mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said V sub  [ml] of said at least one substance and said V gas  [ml] of said pressurized gas, dT deliver , is less than 500 ms; and   wherein the dT deliver  is maintained less than 500 milliseconds independent of the predetermined volume V gas  [ml], V sub  [ml], and the predetermined pressure, P gas  [barg].   
     
     
         8 . The device of  claim 7 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         9 . The device of  claim 7 , wherein at least one of the following is true:
 a. said at least one body cavity is selected from a group consisting of a nasal cavity, the mouth, the throat, an ear, a vagina, a rectum, a urethra, and any combination thereof;   b. a viscosity η of said at least one substance is in a range of 1×10 −3  poise to 1 poise.   c. a velocity of said particles of said at least one substance, after exit from said device, is in a range of about 5 m/s to 50 m/s;   d. said pressurized gas comprises at least one of air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon or any combination thereof;   e. during dispensing of said at least one substance, a mixture of said predetermined volume V gas  [ml] of said pressurized gas with said predetermined mass M sub  [mg] of said at least one substance entrained within it forms a plume of aerosol, said aerosol having a predetermined distribution, said distribution being either homogeneous or heterogeneous, said heterogeneous distribution is selected from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; characteristics of said aerosol selected from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof;   f. a full width of the plume of aerosol comprising said at least one substance and said pressurized gas subtends an angle θ of less than 25°;   g. said at least one substance is selected from a group consisting of a gas, a liquid, a powder, an aerosol, a slurry, a gel, a suspension and any combination thereof;   h. said at least one substance is stored under either an inert atmosphere or under vacuum to prevent reaction during storage;   i. a dose-response curve is substantially linear for a brain concentration of said at least one substance when administered nasally via said device; and,   j. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof of said at least one substance when administered nasally via said device.   
     
     
         10 . The device of  claim 9 , wherein said at least one capsule has a main longitudinal axis, said at least one capsule comprising a number n of compartments, said at least one capsule configured to contain said predetermined mass M sub  [mg] of said at least one substance, said predetermined mass M sub  [mg] of said at least one substance containable in at least one of said n compartments; at least one of the following being true:
 a. the number n of said compartments is an integer greater than or equal to 1; said compartments being annular; at least one of said compartments has a cross-section with a shape selected from a group consisting of: circular, oval, elliptical, polygonal and any combination thereof;   b. for said number n of compartments being an integer greater than 1, at least two said compartments have different volumes;   c. for said number n of compartments being an integer greater than 1, at least two said compartments have the same volume;   d. for said number n of compartments being an integer greater than 1, at least two said compartments have different cross-sectional areas;   e. for said number n of compartments being an integer greater than 1, at least two said compartments have the same cross-sectional area;   f. for said number n of compartments being an integer greater than 1, at least two said compartments contain different substances;   g. for said number n of compartments being an integer greater than 1, at least two said compartments contain the same substance;   h. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed coaxially around said main longitudinal axis of said at least one capsule;   i. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed sequentially along said main longitudinal axis of said at least one capsule;   j. for said number n of compartments greater than 1, there is mixing of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during dispensing; and   k. for said number n of compartments greater than 1, there is a reaction of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during said dispensing.   
     
     
         11 . The device of  claim 7 , wherein said at least one capsule comprises a port fluidly connectable to the exterior of said device, said port configured such that a substance is insertable into said capsule via said port. 
     
     
         12 . The device of  claim 11 , wherein said device comprises a port cover configured to provide an air-tight closure for said port, said port cover selected from a group consisting of slidable along said device, rotatable around said device, rotatable around a hinge on an exterior of said device and any combination thereof. 
     
     
         13 . A method of delivering a predetermined volume V sub  [ml] of at least one substance within at least one body cavity of a subject, comprising:
 a. providing a device comprising:
 i. at least one capsule sized and shaped for containing said predetermined volume V sub  [ml] of said at least one substance; wherein said predetermined volume V sub  [ml] is in a range of 0.01-7 ml; 
 ii. a nozzle in fluid communication with said at least one capsule; said nozzle comprising at least one orifice, wherein said diameter D [mm] of said at least one orifice is in a range of 0.2-6 mm; 
 iii. at least one valve mechanically connected to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of said predetermined volume V sub  [ml] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined volume V sub  [ml] of said at least one substance from said at least one capsule to said at least one body cavity;
 said at least one valve is reconfigurable from said inactive configuration to said active configuration, within a predetermined period of time, dT, in response to activation of said at least one valve; wherein said predetermined period of time dT is less than or equal to 200 ms; and 
 
 iv. a fluid tight chamber configured to contain predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg]; wherein said predetermined pressure P gas  is in a range of 1-10 barg; 
   b. placing said nozzle in proximity to said at least one body cavity;   c. reconfiguring said at least one valve from said inactive configuration to said active configuration thereby entraining said at least one substance in said predetermined volume V gas  [ml] of said pressurized gas; thereby   d. delivering said predetermined volume V sub  [ml] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice in (a) a pressure rate of dP gas /dT, (b) a volume rate of dV gas /dT; and (c) a volume rate of dV sub /dT; wherein said predetermined volume V gas  [ml] of said pressurized gas at said predetermined pressure P gas  [barg] is released from said fluid-tight chamber upon activation of said at least one valve, said predetermined volume V gas  [ml] of said pressurized gas entrains said at least one substance, erupts via said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said predetermined volume V sub  [ml] of said at least one substances and said predetermined volume V gas  [ml] of said pressurized gas, dT deliver , is less than 500 ms, wherein the dT deliver  is maintained less than 500 milliseconds independent of the predetermined volume V gas  [ml], V sub  [ml], and the predetermined pressure, P gas  [barg].   
     
     
         14 . The method of  claim 13 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         15 . The method of  claim 13 , additionally comprising at least one of the following steps:
 a. selecting said at least one body cavity from a group consisting of a nasal cavity, a mouth, a throat, an ear, a vagina, a rectum, a urethra, and any combination thereof;   b. selecting viscosity η of said at least one substance to be in a range of 1×10 −3  poise to 1 poise;   c. characterizing a velocity of said particles of said at least one substance, after exit from said device, as being in a range of 5 m/s to 50 m/s;   d. selecting said gas from a group consisting of: air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon and any combination thereof;   e. dispensing said at least one substance, and during said step of dispensing, forming a plume of aerosol with predetermined distribution from a mixture of said predetermined volume V gas  [ml] of said pressurized gas and said predetermined volume V sub  [ml] entrained within it; selecting said predetermined distribution from a group consisting of: a homogeneous distribution, a heterogeneous distribution; selecting said heterogeneous distribution from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; selecting characteristics of said aerosol from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof;   f. characterizing the plume of said aerosol by a plume angle θ, said plume angle θ subtending a full width of said plume, said plume angle θ subtending an angle of less than 25°;   g. selecting said at least one substance from a group consisting of: a gas, a liquid, a powder, a slurry, a gel, a suspension, and any combination thereof;   h. storing at least one said at least one substance under either an inert atmosphere or under vacuum, thereby preventing reaction during storage; and   i. characterizing a dose-response curve for a brain concentration of said at least one substance to be of substantially linear form;   j. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof of said at least one substance when administered nasally via said device.   
     
     
         16 . The method of  claim 13 , additionally comprising steps of providing said at least one capsule having a main longitudinal axis, said at least one capsule comprising a number n of compartments, configuring said at least one capsule to contain said predetermined volume V sub  [ml] of said at least one substance, containing said predetermined volume V sub  [ml] of said at least one substance in at least one of said n compartments; additionally comprising at least one of the following steps:
 a. providing said at least one capsule with n compartments; n is an integer greater than or equal to 1; said compartments being annular;   b. selecting a cross-sectional shape of at least one of said n compartments from a group consisting of: circular, oval, elliptical, polygonal and any combination thereof;   c. for said number n of compartments being an integer greater than 1, providing at least two of said plurality of said compartments having different volumes;   d. for said number n of compartments being an integer greater than 1, providing at least two said compartments having the same volume;   e. for said number n of compartments being an integer greater than 1, providing at least two said compartments having different cross-sectional areas;   f. for said number n of compartments being an integer greater than 1, providing at least two said compartments having the same cross-sectional area;   g. for said number n of compartments being an integer greater than 1, providing at least two of said compartments containing different substances;   h. for said number n of compartments being an integer greater than 1, providing at least two of said compartments containing the same substance;   i. for said number n of compartments being an integer greater than 1, disposing said plurality of compartments coaxially around said main longitudinal axis of said at least one capsule;   j. for said number n of compartments being an integer greater than 1, disposing said plurality of compartments sequentially along said main longitudinal axis of said at least one capsule;   k. for said number n of compartments being an integer greater than 1, mixing said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during dispensing; and   l. for said number n of compartments being an integer greater than 1, reacting said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during said dispensing.   
     
     
         17 . The method of  claim 13 , additionally comprising step of inserting said predetermined volume V sub  [ml] of said at least one substance into said at least one capsule via a port fluidly connectable to the exterior of said device. 
     
     
         18 . The method of  claim 17 , additionally comprising step of providing an air-tight closure for said port, and of moving said port cover relative to said device in at least one motion selected from a group consisting of: sliding said port cover along said device, rotating said port cover around said device, rotating said port cover around a hinge on the exterior of said device and any combination thereof. 
     
     
         19 . A method of delivering a predetermined mass M sub  [mg] of at least one substance within at least one body cavity of a subject, comprising:
 a. providing a device comprising:
 i. at least one capsule sized and shaped for containing said predetermined mass M sub  [mg] of said at least one substance; wherein said predetermined mass M sub  [mg] is in a range of 1-1000 mg; 
 ii. a nozzle in fluid communication with said at least one capsule; said nozzle comprising at least one orifice, wherein said diameter D [mm] of the at least one orifice is in a range of 0.2-6 mm; 
 iii. at least one valve mechanically connected to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of said predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and, (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity;
 said at least one valve is reconfigurable from said inactive configuration to said active configuration, within a predetermined period of time, dT, in response to activation of said at least one valve; wherein said predetermined period of time dT is less than or equal to 200 ms; and 
 
 iv. a fluid tight chamber adapted to contain predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg]; wherein said predetermined pressure P gas  is in a range of 1-10 barg; 
   b. placing said nozzle in proximity to said at least one body cavity;   c. reconfiguring said at least one valve from said inactive configuration to said active configuration thereby entraining said at least one substance in said predetermined volume V gas  [ml] of said pressurized gas; thereby   d. delivering said predetermined mass M sub  [mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice in (a) a pressure rate of dP gas /dT, (b) a volume rate of dV gas /dT; and (c) a volume rate of dV sub /dT; wherein said predetermined volume V gas  [ml] of said pressurized gas at said predetermined pressure P gas  [barg] is released from said fluid-tight chamber upon activation of said at least one valve, said predetermined volume V gas  [ml] of said pressurized gas entrains said at least one substance, erupts via said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said predetermined volume V sub  [ml] of said at least one substances and said predetermined volume V gas  [ml] of said pressurized gas, dT deliver , is less than 500 ms, wherein the dT deliver  is maintained less than 500 milliseconds independent of the predetermined volume V gas  [ml], V sub  [ml], and the predetermined pressure, P gas  [barg].   
     
     
         20 . The method of  claim 19 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         21 . The method of  claim 19 , additionally comprising at least one of the following:
 a. selecting said at least one body cavity from a group consisting of a nasal cavity, a mouth, a throat, an ear, a vagina, a rectum, a urethra, and any combination thereof;   b. selecting viscosity η of said at least one substance to be in a range of 1×10 −3  poise to 1 poise;   c. characterizing a velocity of said particles of said at least one substance, after exit from said device, as being in a range of about 5 m/s to 50 m/s;   d. selecting said gas from a group consisting of: air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon and any combination thereof;   e. dispensing said at least one substance, and during said step of dispensing, forming a plume of aerosol with predetermined distribution from a mixture of said predetermined volume V gas  [ml] of said pressurized gas and said predetermined mass M sub  [mg] entrained within it; selecting said predetermined distribution from a group consisting of: a homogeneous distribution, a heterogeneous distribution; selecting said heterogeneous distribution from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; selecting characteristics of said aerosol from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof;   f. characterizing said plume of said aerosol by a plume angle θ, said plume angle θ subtending a full width of said plume, said plume angle θ subtending an angle of less than 25°;   g. selecting said at least one substance from a group consisting of: a gas, a liquid, a powder, a slurry, a gel, a suspension, and any combination thereof;   h. storing at least one said at least one substance under either an inert atmosphere or under vacuum, thereby preventing reaction during storage;   i. characterizing a dose-response curve for a brain concentration of said at least one substance to be of substantially linear form; and   j. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof of said at least one substance when administered nasally via said device.   
     
     
         22 . The device of  claim 1 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         23 . The device of  claim 1 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said active configuration;   (b) said predetermined volume V sub  [ml] of said at least one substance;   (c) said predetermined volume V gas  [ml] of said pressurized gas; and,   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         24 . The device of  claim 1 , wherein at least one of the following is being held true:
 (a) said pressure velocity dP gas /dT or dP gas /dT deliver  is greater than 0.001 barg/ms;   (b) said volume rate dV sub /dT or dV sub /dT deliver  is greater than 0.0001 ml/ms; and   (c) said volume rate dV gas /dT or dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         25 . The device of  claim 7 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         26 . The device of  claim 7 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said active configuration;   (b) said predetermined volume V sub  [ml] of said at least one substance;   (c) said predetermined volume V gas  [ml] of said pressurized gas; and,   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         27 . The device of  claim 6 , wherein at least one of the following is being held true:
 (d) said pressure velocity dP gas /dT or dP gas /dT deliver  is greater than 0.001 barg/ms;   (e) said volume rate dV sub /dT or dV sub /dT deliver  is greater than 0.0001 ml/ms; and   (f) said volume rate dV gas /dT or dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         28 . The method of  claim 13 , additionally comprising step of either pre-pressurizing said fluid-tight chamber with said gas to said predetermined pressure; or pressurizing said fluid-tight chamber with said gas to said predetermined pressure before reconfiguring said valve from said inactive configuration to said active configuration. 
     
     
         29 . The method of  claim 13 , additionally comprising step of storing the substance within the capsule prior to being dispensed, wherein the substance is dispensed during activation. 
     
     
         30 . The method of  claim 13 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         31 . The method of  claim 13 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said ACTIVE CONFIGURATION;   (b) said predetermined volume V sub  [ml] of said at least one substance;   (c) said predetermined volume V gas  [ml] of said pressurized gas; and,   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         32 . The method of  claim 11 , wherein at least one of the following is being held true:
 (a) said pressure rate dP gas /dT or pressure rate dP gas /dT deliver  is greater than 0.001 barg/ms;   (b) said volume rate dV sub /dT or volume rate dV sub /dT deliver  is greater than 0.0001 ml/ms; and   (c) said volume rate dV gas /dT or volume rate dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         33 . The method of  claim 19 , additionally comprising step of either pre-pressurizing said fluid-tight chamber with said gas to said predetermined pressure; or pressurizing said fluid-tight chamber with said gas to said predetermined pressure before reconfiguring said valve from said inactive configuration to said active configuration. 
     
     
         34 . The method of  claim 19 , additionally comprising step of storing the substance within the capsule prior to being dispensed, wherein the substance is dispensed during activation. 
     
     
         35 . The method of  claim 19 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         36 . The method of  claim 19 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said active configuration;   (b) said predetermined volume V sub  [ml] of said at least one substance;   (c) said predetermined volume V gas  [ml] of said pressurized gas; and,   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         37 . The method of  claim 19 , wherein at least one of the following is being held true:
 (a) said pressure velocity dP gas /dT or pressure rate dP gas /dT deliver  is greater than 0.001 barg/ms;   (b) said mass rate dM sub /dT or dM sub /dT deliver  is greater than 0.0001 ml/ms; and   (c) said volume rate dV gas /dT volume rate dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         38 . The device of  claim 1 , wherein the nozzle comprises a nozzle tip portion and a tip extension that surrounds the nozzle tip portion and has a larger diameter than the nozzle tip portion, wherein the nozzle tip portion defines the at least one orifice through which the at least one substance exits longitudinally from the nozzle, wherein the tip extension defines at least one hole through which the at least one substance exits laterally from the nozzle. 
     
     
         39 . The device of  claim 1 , wherein the velocity of the particles of the at least one substance, after the exit from the device, is maintained in the range of about 5 m/s to 50 m/s, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         40 . The device of  claim 1 , wherein, during delivery of the at least one substance, a mixture of the predetermined volume V gas  [ml] of the pressurized gas with the predetermined volume V sub  [ml] of the at least one substance entrained within the predetermined volume V gas  [ml] of the pressurized gas forms a plume of aerosol, wherein a full width of the plume of aerosol subtends an angle θ of less than 25°. 
     
     
         41 . The device of  claim 40 , wherein the full width of the plume of aerosol is maintained at the angle θ of less than 25°, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         42 . The device of  claim 40 , wherein the full width of the plume of aerosol, as measured at 6 cm from the nozzle, is 21 mm or less. 
     
     
         43 . The device of  claim 1 , wherein said at least one valve is characterized by an internal diameter, through which said pressurized gas exits said fluid tight chamber and enters said nozzle, which is above 0.22 mm, such that said dT deliver  is maintained less than 500 milliseconds independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         44 . The device of  claim 7 , wherein the velocity of the particles of the at least one substance, after the exit from the device, is maintained in the range of about 5 m/s to 50 m/s, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         45 . The device of  claim 7 , wherein, during delivery of the at least one substance, a mixture of the predetermined volume V gas  [ml] of the pressurized gas with the predetermined volume V sub  [ml] of the at least one substance entrained within the predetermined volume V gas  [ml] of the pressurized gas forms a plume of aerosol, wherein a full width of the plume of aerosol subtends an angle θ of less than 25°. 
     
     
         46 . The device of  claim 45 , wherein the full width of the plume of aerosol is maintained at the angle θ of less than 25°, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         47 . The device of  claim 45 , wherein the full width of the plume of aerosol, as measured at 6 cm from the nozzle, is 21 mm or less. 
     
     
         48 . The device of  claim 7 , wherein said at least one valve is characterized by an internal diameter, through which said pressurized gas exits said fluid tight chamber and enters said nozzle, which is above 0.22 mm, such that said dT deliver  is maintained less than 500 milliseconds independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         49 . A device for delivering a predetermined mass M sub  [mg] of at least one substance within at least one body cavity of a subject, said device comprising:
 a. at least one capsule sized and shaped for containing said predetermined mass M sub  [mg] of said at least one substance, wherein said predetermined mass M sub  [mg] is in a range of 1-1000 mg;   b. a nozzle configured for placement in proximity to said at least one body cavity, said nozzle being in fluid communication with said at least one capsule, said nozzle comprising at least one orifice, wherein a diameter D [mm] of the least one orifice is in a range of 0.2-6 mm;   c. at least one valve mechanically connectable to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of the predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined mass M sub  [mg] of said at least one substance from said at least one capsule to said at least one body cavity, said at least one valve being reconfigurable from said inactive configuration to said active configuration within a predetermined period of time, dT, in response to activation of said at least one valve, wherein said predetermined period of time dT is less than or equal to 200 ms; and   d. a fluid tight chamber configured to contain predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg], wherein said predetermined pressure P gas  [barg] is in a range of 1-10 barg;   e. said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, is configured to entrain said at least one substance and deliver said at least one substance via said at least one orifice in said nozzle within said at least one body cavity,
 wherein said device is configured to deliver said predetermined mass M sub  [mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said predetermined mass M sub  [mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas, dT deliver , is less than 500 ms, and 
 wherein said at least one valve is characterized by an internal diameter, through which said pressurized gas exits said fluid tight chamber and enters said nozzle, which is above 0.22 mm, such that said dT deliver  is maintained less than 500 milliseconds independent of at least one of the predetermined volume V gas  [ml], the predetermined mass M sub  [mg], and the predetermined pressure P gas  [barg]. 
   
     
     
         50 . The device of  claim 49 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         51 . The device of  claim 49 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         52 . The device of  claim 49 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said active configuration;   (b) said predetermined volume V sub  [ml] of said at least one substance;   (c) said predetermined volume V gas  [ml] of said pressurized gas; and   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         53 . The device of  claim 49 , wherein at least one of the following is being held true:
 (g) said pressure velocity dP gas /dT or dP gas /dT deliver  is greater than 0.001 barg/ms;   (h) said volume rate dV sub /dT or dV sub /dT deliver  is greater than 0.0001 ml/ms; and   (i) said volume rate dV gas /dT or dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         54 . The device of  claim 49 , wherein the nozzle comprises a nozzle tip portion and a tip extension that surrounds the nozzle tip portion and has a larger diameter than the nozzle tip portion, wherein the nozzle tip portion defines the at least one orifice through which the at least one substance exits longitudinally from the nozzle, wherein the tip extension defines at least one hole through which the at least one substance exits laterally from the nozzle. 
     
     
         55 . The device of  claim 49 , wherein the velocity of the particles of the at least one substance, after the exit from the device, is maintained in the range of about 5 m/s to 50 m/s, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         56 . The device of  claim 49 , wherein, during delivery of the at least one substance, a mixture of the predetermined volume V gas  [ml] of the pressurized gas with the predetermined volume V sub  [ml] of the at least one substance entrained within the predetermined volume V gas  [ml] of the pressurized gas forms a plume of aerosol, wherein a full width of the plume of aerosol subtends an angle θ of less than 25°. 
     
     
         57 . The device of  claim 56 , wherein the full width of the plume of aerosol is maintained at the angle θ of less than 25°, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume Vsub [ml], and the predetermined pressure P gas  [barg]. 
     
     
         58 . The device of  claim 56 , wherein the full width of the plume of aerosol, as measured at 6 cm from the nozzle, is 21 mm or less. 
     
     
         59 . The device of  claim 49 , wherein at least one of the following is true:
 a. said at least one body cavity is selected from a group consisting of a nasal cavity, the mouth, the throat, an ear, a vagina, a rectum, a urethra, and any combination thereof;   b. viscosity η of said at least one substance is in a range of 1λ10 −3  poise to 1 poise;   c. a velocity of said particles of said at least one substance, after exit from said device, is in a range of about 5 m/s to 50 m/s;   d. said pressurized gas comprises at least one of air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon or any combination thereof;   e. during dispensing of said at least one substance, a mixture of said predetermined volume V gas  [ml] of said pressurized gas with said predetermined mass M sub  [mg] of said at least one substance entrained within it forms a plume of aerosol, said aerosol having a predetermined distribution, said distribution being either homogeneous or heterogeneous, said heterogeneous distribution is selected from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; characteristics of said aerosol selected from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof f a full width of the plume of aerosol comprising said at least one substance and said pressurized gas subtends an angle θ of less than 25°;   g. said at least one substance is selected from a group consisting of a gas, a liquid, a powder, an aerosol, a slurry, a gel, a suspension and any combination thereof;   h. said at least one substance is stored under either an inert atmosphere or under vacuum to prevent reaction during storage;   i. a dose-response curve is substantially linear for a brain concentration of said at least one substance when administered nasally via said device; and   j. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof of said at least one substance when administered nasally via said device.   
     
     
         60 . The device of  claim 59 , wherein said at least one capsule has a main longitudinal axis, said at least one capsule comprising a number n of compartments, said at least one capsule configured to contain said predetermined mass M sub  [mg] of said at least one substance, said predetermined mass M sub  [mg] of said at least one substance containable in at least one of said n compartments; at least one of the following being true:
 a. the number n of said compartments is an integer greater than or equal to 1; said compartments being annular; at least one of said compartments has a cross-section with a shape selected from a group consisting of: circular, oval, elliptical, polygonal and any combination thereof;   b. for said number n of compartments being an integer greater than 1, at least two said compartments have different volumes;   c. for said number n of compartments being an integer greater than 1, at least two said compartments have the same volume;   d. for said number n of compartments being an integer greater than 1, at least two said compartments have different cross-sectional areas;   e. for said number n of compartments being an integer greater than 1, at least two said compartments have the same cross-sectional area;   f. for said number n of compartments being an integer greater than 1, at least two said compartments contain different substances;   g. for said number n of compartments being an integer greater than 1, at least two said compartments contain the same substance;   h. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed coaxially around said main longitudinal axis of said at least one capsule;   i. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed sequentially along said main longitudinal axis of said at least one capsule;   j. for said number n of compartments greater than 1, there is mixing of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during dispensing; and   k. for said number n of compartments greater than 1, there is a reaction of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during said dispensing.   
     
     
         61 . The device of  claim 49 , wherein said at least one capsule comprises a port fluidly connectable to the exterior of said device, said port configured such that a substance is insertable into said capsule via said port. 
     
     
         62 . The device of  claim 61 , wherein said device comprises a port cover configured to provide an air-tight closure for said port, said port cover selected from a group consisting of slidable along said device, rotatable around said device, rotatable around a hinge on an exterior of said device and any combination thereof. 
     
     
         63 . A device for delivering a predetermined volume V sub  [ml or mg] of at least one substance within at least one body cavity of a subject, said device comprising:
 at least one capsule sized and shaped for containing said predetermined volume V sub  [ml or mg] of said at least one substance, wherein said predetermined volume V sub  [ml or mg] is in a range of 0.01-7 ml or 0.01-1000 mg;   a nozzle configured for placement in proximity to said at least one body cavity, said nozzle being in fluid communication with said at least one capsule, said nozzle comprising at least one orifice, wherein a diameter D [mm] of the least one orifice is in a range of 0.2-6 mm;   at least one valve mechanically connectable to said at least one capsule, characterized by at least two configurations: (i) an active configuration in which said at least one valve enables delivery of the predetermined volume V sub  [ml or mg] of said at least one substance from said at least one capsule to said at least one body cavity via said nozzle; and (ii) an inactive configuration, in which said at least one valve prevents delivery of said predetermined volume V sub  [ml or mg] of said at least one substance from said at least one capsule to said at least one body cavity, said at least one valve being reconfigurable from said inactive configuration to said active configuration within a predetermined period of time, dT, in response to activation of said at least one valve, wherein said predetermined period of time dT is less than or equal to 200 ms; and   a fluid tight chamber configured to contain predetermined volume V gas  [ml] of pressurized gas at a predetermined pressure, P gas  [barg], wherein said predetermined pressure P gas  [barg] is in a range of 1-10 barg;
 said pressurized gas, once said at least one valve is reconfigured from said inactive configuration to said active configuration, is configured to entrain said at least one substance and deliver said at least one substance via said at least one orifice in said nozzle within said at least one body cavity, 
 wherein said device is configured to deliver said predetermined volume V sub  [ml or mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas through said at least one orifice into said at least one body cavity, such that a release time of substantially the entirety of said predetermined volume V sub  [ml or mg] of said at least one substance and said predetermined volume V gas  [ml] of said pressurized gas, dT deliver , is less than 500 ms; 
 wherein said at least one valve is characterized by an internal diameter, through which said pressurized gas exits said fluid tight chamber and enters said nozzle, which is above 0.22 mm, such that said dT deliver  is maintained less than 500 milliseconds independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml or mg], and the predetermined pressure P gas  [barg]; and 
 further wherein said body cavity is selected from a group consisting of a nasal cavity, a mouth, a throat, an ear, a vagina, a rectum, a urethra, and any combination thereof. 
   
     
     
         64 . The device of  claim 63 , wherein said predetermined volume V gas  [ml], when compressed, is in a range of 1-21 ml. 
     
     
         65 . The device of  claim 63 , wherein at least one of the following is true:
 a. viscosity η of said at least one substance is in a range of 1×10 −3  poise to 1 poise;   b. a velocity of said particles of said at least one substance, after exit from said device, is in a range of about 5 m/s to 50 m/s;   c. said pressurized gas comprises at least one of air, nitrogen, oxygen, carbon dioxide, helium, neon, xenon and any combination thereof;   d. during dispensing of said at least one substance, a mixture of said predetermined volume V gas  [ml] of said pressurized gas with said predetermined volume V sub  [ml] of said at least one substance entrained within it forms a plume of aerosol; said aerosol having a predetermined distribution, said distribution being either homogeneous or heterogeneous, said heterogeneous distribution is selected from a group consisting of: an arbitrary distribution, a distribution in which the density of said at least one substance within said mixture follows a predetermined pattern, and any combination thereof; characteristics of said aerosol selected from a group consisting of: particle size, particle shape, particle distribution, and any combination thereof, are determinable from characteristics of said device selected from a group consisting of: said predetermined volume of said pressurized gas, said predetermined volume of said at least one substance, said predetermined pressure of said pressurized gas, said diameter D [mm] of said at least one orifice, and any combination thereof;   e. said at least one substance is selected from a group consisting of a gas, a liquid, a powder, an aerosol, a slurry, a gel, a suspension and any combination thereof;   f. said at least one substance is stored under either an inert atmosphere or under vacuum to prevent reaction during storage;   g. a dose-response curve is substantially linear for a brain concentration of said at least one substance when administered nasally via said device; and   h. a dose-response curve for a brain concentration having a fit selected from a group consisting of logarithmic, parabolic, exponential, sigmoid, power-low, and any combination thereof of said at least one substance when administered nasally via said device.   
     
     
         66 . The device of  claim 63 , wherein said at least one capsule has a main longitudinal axis, said at least one capsule comprising a number n of compartments, said at least one capsule configured to contain said predetermined volume V sub  [ml] of said at least one substance, said predetermined volume V sub  [ml] of said at least one substance containable in at least one of said n compartments; at least one of the following being true:
 a. the number n of said compartments is an integer greater than or equal to 1; said compartments being annular; at least one of said compartments has a cross-section with a shape selected from a group consisting of: circular, oval, elliptical, polygonal and any combination thereof;   b. for said number n of compartments being an integer greater than 1, at least two said compartments have different volumes;   c. for said number n of compartments being an integer greater than 1, at least two said compartments have the same volume;   d. for said number n of compartments being an integer greater than 1, at least two said compartments have different cross-sectional areas;   e. for said number n of compartments being an integer greater than 1, at least two said compartments have the same cross-sectional area;   f. for said number n of compartments being an integer greater than 1, at least two said compartments contain different substances;   g. for said number n of compartments being an integer greater than 1, at least two said compartments contain the same substance;   h. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed coaxially around said main longitudinal axis of said at least one capsule;   i. for said number n of compartments being an integer greater than 1, at least two said compartments are disposed sequentially along said main longitudinal axis of said at least one capsule;   j. for said number n of compartments greater than 1, there is mixing of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during dispensing; and   k. for said number n of compartments greater than 1, there is a reaction of said at least one substance in at least one of said n compartments with said at least one substance in at least one other of said n compartments during said dispensing.   
     
     
         67 . The device of  claim 63 , wherein said at least one capsule comprises a port fluidly connectable to the exterior of said device, said port configured such that said at least one substance is insertable into said fluid-tight chamber via said port. 
     
     
         68 . The device of  claim 67 , wherein said device comprises a port cover configured to provide an air-tight closure for said port, said port cover selected from a group consisting of slidable along said device, rotatable around said device, rotatable around a hinge on an exterior of said device and any combination thereof. 
     
     
         69 . The device of  claim 63 , wherein said dT deliver  is maintained less than 500 ms independent of how a user may operate the device. 
     
     
         70 . The device of  claim 63 , wherein said dT deliver  is maintained less than 500 ms independent of at least one selected from a group consisting of:
 (a) a force required to reconfigured said at least one valve from said inactive configuration to said active configuration;   (b) said predetermined volume V sub  [ml or mg] of said at least one substance;   (c) said predetermined volume V gas  [ml or mg] of said pressurized gas; and   (d) said predetermined pressure, P gas  [barg] of said pressurized gas.   
     
     
         71 . The device of  claim 63 , wherein at least one of the following is being held true:
 (j) said pressure velocity dP gas /dT or dP gas /dT deliver  is greater than 0.001 barg/ms;   (k) said volume rate dV sub /dT or dV sub /dT deliver  is greater than 0.0001 ml/ms; and   (l) said volume rate dV gas /dT or dV gas /dT deliver  is greater than 0.001 ml/ms.   
     
     
         72 . The device of  claim 63 , wherein the nozzle comprises a nozzle tip portion and a tip extension that surrounds the nozzle tip portion and has a larger diameter than the nozzle tip portion, wherein the nozzle tip portion defines the at least one orifice through which the at least one substance exits longitudinally from the nozzle, wherein the tip extension defines at least one hole through which the at least one substance exits laterally from the nozzle. 
     
     
         73 . The device of  claim 63 , wherein the velocity of the particles of the at least one substance, after the exit from the device, is maintained in the range of about 5 m/s to 50 m/s, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml or mg], and the predetermined pressure P gas  [barg]. 
     
     
         74 . The device of  claim 63 , wherein, during delivery of the at least one substance, a mixture of the predetermined volume V gas  [ml] of the pressurized gas with the predetermined volume V sub  [ml or mg] of the at least one substance entrained within the predetermined volume V gas  [ml] of the pressurized gas forms a plume of aerosol, wherein a full width of the plume of aerosol subtends an angle θ of less than 25°. 
     
     
         75 . The device of  claim 73 , wherein the full width of the plume of aerosol is maintained at the angle θ of less than 25°, independent of at least one of the predetermined volume V gas  [ml], the predetermined volume V sub  [ml], and the predetermined pressure P gas  [barg]. 
     
     
         76 . The device of  claim 73 , wherein the full width of the plume of aerosol, as measured at 6 cm from the nozzle, is 21 mm or less.