PTH Prodrugs

Abstract

The present invention relates to PTH prodrugs, pharmaceutical compositions comprising such PTH prodrugs and their uses.

1 - 18 . (canceled) 
     
     
         19 . A parathyroid hormone (PTH) conjugate of formula (IIf-i) or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein 
         the unmarked dashed line indicates the attachment to the N-terminal nitrogen of a PTH moiety having the sequence of SEQ ID NO:51; and 
         the dashed line marked with the asterisk indicates attachment to a moiety 
       
       
         
           
           
               
               
           
         
         wherein 
         m and p are independently an integer ranging from and including 400 to 500. 
       
     
     
         20 . The PTH conjugate or a pharmacological salt thereof of  claim 19 , wherein the moiety 
       
         
           
           
               
               
           
         
       
       has a molecular weight of about 40 kDa. 
     
     
         21 . The PTH conjugate or a pharmacological salt thereof of  claim 19 , wherein m and p are the same integer. 
     
     
         22 . The PTH conjugate or a pharmacological salt thereof of  claim 19 , wherein m and p are about 450. 
     
     
         23 . A pharmaceutical composition comprising at least one PTH conjugate or a pharmaceutically acceptable salt thereof of  claim 19  and at least one excipient. 
     
     
         24 . The pharmaceutical composition of  claim 19 , wherein the pharmaceutical composition has a pH ranging from and including pH 4 to pH 6. 
     
     
         25 . A method of treating a patient having hypoparathyroidism comprising administering an effective amount of the PTH conjugate or pharmaceutically acceptable salt thereof of claim  1  or a pharmaceutical composition comprising such PTH conjugate or pharmaceutically acceptable salt thereof to the patient.