Method of adjusting a blended extended depth of focus light adjustable lens with laterally offset axes

Abstract

A Light Adjustable Lens (LAL) comprises a central region, centered on a central axis, having a position-dependent central optical power, and a peripheral annulus, centered on an annulus axis and surrounding the central region, having a position-dependent peripheral optical power; wherein the central optical power is at least 0.5 diopters different from an average of the peripheral optical power, and the central axis is laterally shifted relative to the annulus axis. A method of adjusting the LAL comprises implanting a LAL; applying a first illumination to the LAL with a first illumination pattern to induce a position-dependent peripheral optical power in at least a peripheral annulus, centered on an annulus axis; determining a central region and a corresponding central axis of the LAL; and applying a second illumination to the LAL with a second illumination pattern to induce a position-dependent central optical power in the central region of the LAL.

1 . A method of adjusting a Light Adjustable Lens (LAL), the method comprising the steps of:
 implanting a LAL into an eye;   applying a first illumination to the LAL with a first illumination pattern to induce a position-dependent peripheral optical power in at least a peripheral annulus, centered on an annulus axis;   determining a central region and a corresponding central axis of the LAL; and   applying a second illumination to the LAL with a second illumination pattern to induce a position-dependent central optical power in the central region of the LAL; wherein
 the central axis is laterally shifted relative to the annulus axis, and 
 an average of the central optical power is at least 0.5 diopters different from an average of the peripheral optical power. 
   
     
     
         2 . The method of  claim 1 , wherein:
 the average of the central optical power is at least 1.0 diopter different from the average of the peripheral optical power.   
     
     
         3 . The method of  claim 1 , wherein:
 the average of the central optical power is at least 0.5 diopters higher than an average of the peripheral optical power.   
     
     
         4 . The method of  claim 1 , wherein:
 the average of the central optical power is at least 0.5 diopters lower than an average of the peripheral optical power.   
     
     
         5 . The method of  claim 1 , the applying the first illumination comprising:
 applying the first illumination with a first illumination pattern to induce the position-dependent peripheral optical power in a light-adjusted region that includes the peripheral annulus and the central region.   
     
     
         6 . The method of  claim 1 , the determining a central axis comprising:
 identifying a visual axis of the eye as the central axis.   
     
     
         7 . The method of  claim 1 , the determining a central axis comprising:
 determining the central axis with an iris of the eye being in a non-dilated state.   
     
     
         8 . The method of  claim 1 , the determining a central axis comprising:
 determining the central axis with an iris of the eye being dilated to an iris-radius no more than 30% greater than a non-dilated iris-radius.   
     
     
         9 . The method of  claim 1 , the determining a central axis comprising:
 determining the central axis before an iris of the eye is dilated;   registering the determined central axis with a feature of the eye; and   reconstructing the determined and registered central axis after the iris is dilated, before the applying of the second illumination.   
     
     
         10 . The method of  claim 1 , wherein:
 the applying the first illumination and the applying the second illumination induces a transition between the central region and the peripheral annulus, having a transition optical power that changes from the central optical power to the peripheral optical power.   
     
     
         11 . The method of  claim 1 , wherein:
 the central optical power has an approximately flat position-dependence, having an optical power variation less than 0.2 diopters over a central 50% of the central region.   
     
     
         12 . The method of  claim 1 , wherein:
 a spherical aberration caused by the position-dependence of one of the peripheral optical power, and a combination of the central optical power, the peripheral optical power, and a transition optical power, is in a range of −0.05 μm to −1 μm at a diameter of 4 mm in a plane of the LAL.   
     
     
         13 . The method of  claim 1 , wherein:
 a spherical aberration caused by the position-dependence of one of the peripheral optical power, and a combination of the central optical power, the peripheral optical power, and a transition optical power, is in a range of −0.05 μm to −2 μm at a diameter of 6 mm in a corneal plane of an eye upon an implantation of the LAL in the eye.   
     
     
         14 . The method of  claim 1 , wherein:
 at least on the central optical power and the peripheral optical power is selected such that a spherical aberration caused by the position-dependence of at least one of the central optical power and the peripheral optical power approximately compensates a spherical aberration of a cornea of the eye.   
     
     
         15 . The method of  claim 1 , wherein:
 at least one of   the position-dependent central optical power involves a cylinder angular dependence; and   the position-dependent peripheral optical power involves a cylinder angular dependence.   
     
     
         16 . The method of  claim 1 , wherein:
 the applying the first illumination and the applying the second illumination is separated by less than 48 hours.   
     
     
         17 . The method of  claim 1 , comprising:
 applying a lock-in illumination, to lock in the induced peripheral optical power and the induced central optical power in the LAL.   
     
     
         18 . The method of  claim 1 , further comprising:
 applying a third illumination to the LAL with a third illumination pattern centered on the central axis to reduce the position-dependent central optical power, induced in by the second illumination in the central region of the LAL.   
     
     
         19 . A method of adjusting a Light Adjustable Lens (LAL), the method comprising the steps of:
 implanting a LAL into an eye, the LAL having a pre-molded position-dependent peripheral optical power in at least a peripheral annulus, centered on an annulus axis;   determining a central region and a corresponding central axis of the LAL; and   applying a central illumination to the LAL with a central illumination pattern to induce a position-dependent central optical power in the central region of the LAL; wherein
 the central axis is laterally shifted relative to the annulus axis, and 
 an average of the central optical power is at least 0.5 diopters different from an average of the peripheral optical power. 
   
     
     
         20 . A method of adjusting a Light Adjustable Lens (LAL), the method comprising the steps of:
 implanting a LAL, having a LAL axis, into an eye; and   applying an illumination to the LAL with an illumination pattern to induce a position-dependent optical power in a light-adjusted region, centered on an adjustment axis; wherein   the adjustment axis is laterally shifted relative to the LAL axis.