Composition for preventing or treating neurodegenerative diseases, containing diterpene-based compound

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof. Specifically, the diterpene of the present invention can prevent or treat neurodegenerative diseases caused by inhibition of Nurr1 activity by activating Nurr1 and inhibiting the inflammatory response.

What is claimed is: 
     
         1 . A pharmaceutical composition for the prevention or treatment of neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof, wherein the diterpene comprises at least one selected from the group comprising Formulas 1 to 16 below. 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         2 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the diterpenes is one of the compounds represented by Formulas 2, 8, 13, 14 or 16. 
     
     
         3 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the diterpene is the compound represented by Formula 2. 
     
     
         4 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the diterpene is the compound represented by Formula 14. 
     
     
         5 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the neurodegenerative diseases may be any one selected from the group consisting of Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Fronto-Temporal Dementia, Cortico Basal Degeneration, and Progressive supranuclear palsy (PSP). 
     
     
         6 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the neurodegenerative disease is Parkinson's disease (PD). 
     
     
         7 . The pharmaceutical composition for the prevention or treatment of neurodegenerative diseases according to  claim 1 , wherein the diterpene is separated from the extract of flower of  Daphne genkwa.    
     
     
         8 . A dietary supplement for preventing or improving neurodegenerative diseases comprising a diterpene, or a pharmaceutically acceptable salt thereof, wherein the diterpene is at least one selected from the group containing Formulas 1 to 16. 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         9 . A dietary supplement for preventing or improving of neurodegenerative diseases according to  claim 8 , wherein the neurodegenerative diseases may be any one selected from the group consisting of Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Fronto-Temporal Dementia, Cortico Basal Degeneration, and Progressive supranuclear palsy (PSP). 
     
     
         10 . A dietary supplement for preventing or improving of neurodegenerative diseases according to  claim 8 , wherein the neurodegenerative disease is Parkinson's disease (PD).