US2022016109A1PendingUtilityA1

Abuse-resistant mucoadhesive devices for delivery of buprenorphine

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Assignee: BIODELIVERY SCIENCES INT INCPriority: Aug 18, 2011Filed: Oct 10, 2020Published: Jan 20, 2022
Est. expiryAug 18, 2031(~5.1 yrs left)· nominal 20-yr term from priority
Inventors:Andrew FinnNiraj Vasisht
A61K 31/485A61K 31/4748A61P 25/00A61K 9/7007A61K 47/14A61K 47/38A61P 29/00A61K 47/32A61K 31/46A61K 47/12A61K 47/10A61K 9/006A61P 25/04A61K 47/02A61P 25/36A61P 43/00A61K 47/22A61P 39/02A61P 1/00
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Claims

Abstract

The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.

Claims

exact text as granted — not AI-modified
1 . An abuse deterrent mucoadhesive device for use in managing pain or opioid dependence, the device comprising:
 a mucoadhesive layer comprising an effective amount of buprenorphine buffered to a pH of between about 4.0 and about 6.0; and   a backing layer buffered to a pH between about 4.0 and about 4.8.   
     
     
         2 - 8 . (canceled)

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