Method for developing organ that lacks specific functional cell

Abstract

Provided is a method for developing a secondary organ by using a non-human animal in which organ formation is inhibited, for the purpose of establishing a process for producing a functional cell such as a β cell within the body of an animal such as a pig, the method including the step of raising a newborn or a fetus of the non-human animal in which organ formation is inhibited by complementing at least a part of the function of the organ whose formation is inhibited.

1 - 18 . (canceled) 
     
     
         19 . A method for establishment and growth of a progenitor cell of a specific functional cell or a pluripotent stem cell, or a functional cell derived therefrom, comprising transplanting the progenitor cell or the pluripotent stem cell into an organ-like tissue, wherein the organ-like tissue is formed by a newborn or a fetus of a genetically modified pig and lacks a functional cell derived from the pig. 
     
     
         20 . The method according to  claim 19 , wherein the progenitor cell of the functional cell or the pluripotent stem cell is a human-derived cell. 
     
     
         21 . A material in which a progenitor cell of a specific functional cell or a pluripotent stem cell, or a functional cell derived therefrom is established and grown, the material lacking a functional cell derived from the pig and comprising organ-like tissue formed by a newborn or a fetus of a genetically modified pig, wherein the progenitor cell or the pluripotent stem cell is transplanted into the organ-like tissue. 
     
     
         22 . The material according to  claim 21 , wherein the progenitor cell of the functional cell or the pluripotent stem cell is a human-derived cell.