Cosmetic compositions and methods of use

Abstract

The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFKB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and it has been discovered that these compounds are particularly useful in the treatment of certain cosmetic applications and in rejuvenating and beautifying skin and other keratinous tissue of a subject in need. Cosmetic compositions and methods of using said compositions in combination with other components are disclosed herein.

1 . A cosmetic composition for use in the treatment, repair, rejuvenation and/or beautification of the skin, including enhancing skin elasticity, the composition comprising an effective amount of at least one compound which exhibits dual activity as a NF-κB signaling inhibitor and a Nrf2 signaling agonist in combination with at least one additional cosmetic additive. 
     
     
         2 . The composition of  claim 1 , wherein said cosmetic additive is water, an alcohol or other water compatible cosmetically acceptable solvent, a water incompatible solvent, an emollient, a humectant, an oil, a conditioning agent, a surfactant, a thickener/thickening agent, a stiffening agent, an emulsifier, a medicament, a fragrance, a preservative, a deodorant component, an anti-perspirant compound, a skin protecting agent, a pigment, a dye, a coloring agent, a preservative or mixtures thereof. 
     
     
         3 . The composition according to  claim 1  further including an anti-acne compound, vitamin C, vitamin E, vitamin A, coenzyme Q, aloe vera or a mixture thereof. 
     
     
         4 . The composition according to  claim 3  wherein said anti-acne compound is a peroxide, such as hydrogen peroxide or benzoyl peroxide, a dialkyl peroxide, a perester, an inorganic peroxide, percarbonate, triclosan, a quaternary compound, such as a quaternary ammonium compound, including benzalkonium chloride, a retinoid such as adapalene, isotretinoin, tretinoin, pharmaceutically acceptable salts and esters thereof, and mixtures thereof. 
     
     
         5 . The composition of  claim 1 , wherein the compound exhibiting dual activity is according to the chemical structure: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         a pharmaceutically acceptable salt thereof, or a mixture thereof. 
       
     
     
         6 . The composition according to  claim 1  wherein said compound(s) exhibiting dual activity is 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof or a mixture thereof. 
       
     
     
         7 . The composition according to  claim 1  wherein said compound exhibiting dual activity is 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         or 
         a pharmaceutically acceptable salt thereof or mixture thereof. 
       
     
     
         8 . The composition according to  claim 1  wherein said compound is 
       
         
           
           
               
               
           
         
       
     
     
         9 . The composition according to  claim 1  wherein said compound is administered to a subject in combination with at least one additional bioactive agent. 
     
     
         10 - 13 . (canceled) 
     
     
         14 . The composition according to  claim 1  wherein said composition includes an effective amount of an essential oil or a terpene. 
     
     
         15 - 17 . (canceled) 
     
     
         18 . The composition according to  claim 1  comprising coconut oil and/or jojoba oil. 
     
     
         19 . A method of treating a cosmetic condition of the keratinous tissue of a subject comprising administering to the subject a composition comprising an effective amount of at least one compound which exhibits dual activity as a NF-κB signaling inhibitor and a Nrf2 signaling agonist, in combination with at least one cosmetic additive, wherein said cosmetic condition is wrinkled skin, acne scars, non-acne scars that won't heal, stretch marks, rashes, damaged skin, rough skin, warts and other skin imperfections, skin discoloration, rashes from poison ivy and poison oak and other environmental insults. 
     
     
         20 - 23 . (canceled) 
     
     
         24 . The method according to  claim 19  wherein said compound is 
       
         
           
           
               
               
           
         
       
     
     
         25 . (canceled) 
     
     
         26 . The method according to  claim 19  wherein said compound is administered in combination with at least one additional bioactive agent. 
     
     
         27 . The method according to  claim 19  wherein composition further comprises an anti-acne compound, vitamin C, vitamin E, vitamin A, coenzyme Q, aloe vera or a mixture thereof. 
     
     
         28 . The method according to  claim 26  wherein said bioactive agent is an anti-acne agent, vitamin C, vitamin E, vitamin A, coenzyme Q, aloe vera or a terpene. 
     
     
         29 - 36 . (canceled) 
     
     
         37 . The composition of  claim 1  comprising an effective amount of compound LD55 in combination with coconut oil and/or jojoba oil, an essential oil or a terpene, and optionally further comprising vitamin E, vitamin C and/or vitamin A. 
     
     
         38 . The composition of  claim 1  comprising an effective amount of compound LD55 and an essential oil or a terpene. 
     
     
         39 - 43 . (canceled) 
     
     
         44 . A method of treating keratinous tissue of a subject to repair, rejuvenate and/or beautify the keratinous tissue of a subject in need, including enhancing skin elasticity, comprising administering to the keratinous tissue of said subject an effective amount of a composition according to  claim 1 . 
     
     
         45 . The method of  claim 44  wherein the composition is administered to wrinkled skin, acne scars, non-acne scars that won't heal, stretch marks, rashes, damaged skin, rough skin, warts and other skin imperfections, skin discoloration, rashes from poison ivy and poison oak and other environmental insults.