Peroxide-less biophotonic compositions and methods

Abstract

The present disclosure provides biophotonic topical compositions, kits and their uses. In some aspects, the biophotonic topical compositions of the present disclosure comprise a first chromophore, a salt selected from one or more bicarbonate or carbonate salts or a combination of the foregoing salts, and one or more gelling agents. In some aspects, the biophotonic topical compositions of the present disclosure comprise a first chromophore, one or more polyols, and one or more gelling agents. The biophotonic compositions of the present disclosure do not include an oxidant selected from the group consisting of a peroxide, a peroxy acid, hydrogen peroxide, carbamide peroxide, an alkali metal peroxide, an alkali metal percarbonate, peroxyacetic acid, and an alkali metal perborate. The biophotonic compositions are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

1 . A biophotonic composition comprising:
 a first chromophore;   one or more gelling agents; and   one or more salts selected from one or more bicarbonate salts, one or more carbonate salts, or a combination of the foregoing salts;   wherein said composition does not include an oxidant selected from the group consisting of a peroxide, a peroxy acid, hydrogen peroxide, carbamide peroxide, an alkali metal peroxide, an alkali metal percarbonate, peroxyacetic acid, and an alkali metal perborate.   
     
     
         2 . The biophotonic composition of claiml, wherein the salt is one or more bicarbonate salts. 
     
     
         3 . The biophotonic composition of  claim 2 , wherein the one or more bicarbonate salts are selected from ammonium bicarbonate, caesium bicarbonate, potassium bicarbonate, sodium bicarbonate, choline bicarbonate, aminoguanidine bicarbonate, or tetraethylammonium bicarbonate. 
     
     
         4 . The biophotonic composition of  claim 3 , wherein the bicarbonate salt is sodium bicarbonate. 
     
     
         5 . The biophotonic composition of  claim 3 , wherein the bicarbonate salt is potassium bicarbonate. 
     
     
         6 . The biophotonic composition of  claim 1 , wherein the salt is one or more carbonate salts. 
     
     
         7 . The biophotonic composition of  claim 6 , wherein the one or more carbonate salts are selected from barium carbonate, beryllium carbonate, caesium carbonate, calcium carbonate, cobalt (II) carbonate, copper (II) carbonate, lithium carbonate, magnesium carbonate, nickel (II) carbonate, potassium carbonate, sodium carbonate, or zinc carbonate. 
     
     
         8 . The biophotonic composition of  claim 7 , wherein the carbonate salt is calcium carbonate. 
     
     
         9 . The biophotonic composition of  claim 7 , wherein the carbonate salt is sodium carbonate. 
     
     
         10 . The biophotonic composition of  claim 7 , wherein the carbonate salt is potassium carbonate. 
     
     
         11 . The biophotonic composition of any one of  claims 1  to  10 , further comprising at least one polyol. 
     
     
         12 . The biophotonic composition of  claim 11 , wherein the polyol is glycerine. 
     
     
         13 . The biophotonic composition of  claim 11 , wherein the polyol is at least one glycol. 
     
     
         14 . The biophotonic composition of  claim 13 , wherein the glycol is selected from ethylene glycol and propylene glycol. 
     
     
         15 . The biophotonic composition of  claim 14 , wherein the glycol is propylene glycol. 
     
     
         16 . A biophotonic composition comprising:
 a first chromophore;   one or more gelling agents; and   one or more polyols;   wherein said composition does not include an oxidant selected from the group consisting of a peroxide, a peroxy acid, hydrogen peroxide, carbamide peroxide, an alkali metal peroxide, an alkali metal percarbonate, peroxyacetic acid, and an alkali metal perborate.   
     
     
         17 . The biophotonic composition of  claim 16 , wherein the polyol is glycerine. 
     
     
         18 . The biophotonic composition of  claim 16 , wherein the polyol is at least one glycol. 
     
     
         19 . The biophotonic composition of  claim 18 , wherein the glycol is selected from the group consisting of ethylene glycol and propylene glycol. 
     
     
         20 . The biophotonic composition of  claim 19 , wherein the glycol is propylene glycol. 
     
     
         21 . The biophotonic composition of any one of  claims 1  to  20 , wherein the first chromophore is present in an amount of from about 0.001% to about 40% by weight of the total composition. 
     
     
         22 . The biophotonic composition of  claim 21 , wherein the first chromophore is present in an amount of from about 0.005% to about 2% by weight of the total composition. 
     
     
         23 . The biophotonic composition of any one of  claims 1  to  20 , wherein the first chromophore is present in an amount of at least about 0.2% by weight of the total composition. 
     
     
         24 . The biophotonic composition of any one of  claims 1 - 23 , wherein the gelling agent is a carbomer comprising a polymer of acrylic acid. 
     
     
         25 . The biophotonic composition of  claim 24 , wherein the carbomer is crosslinked. 
     
     
         26 . The biophotonic composition of any one of  claims 1  to  25 , wherein the first chromophore is in solution in a medium of the composition. 
     
     
         27 . The biophotonic composition of  claim 26 , wherein the medium is an aqueous substance or an alcohol. 
     
     
         28 . The biophotonic composition of  claim 27 , wherein the medium is an aqueous substance. 
     
     
         29 . The biophotonic composition of any one of  claims 1 - 28 , wherein the first chromophore is a fluorescent chromophore. 
     
     
         30 . The biophotonic composition of any one of  claims 1 - 28 , wherein the first chromophore is a xanthene dye. 
     
     
         31 . The biophotonic composition of  claim 30 , wherein the first chromophore is selected from the group consisting of Eosin Y, Eosin B, Erythrosin B, Fluorescein, Rose Bengal, and Phloxin B. 
     
     
         32 . The biophotonic composition of  claim 31 , wherein the first chromophore is Eosin Y. 
     
     
         33 . The biophotonic composition of any one of  claims 1  to  32 , wherein the composition further comprises a second chromophore. 
     
     
         34 . The biophotonic composition of  claim 33 , wherein the first chromophore has an emission spectrum that overlaps at least 20% with an absorption spectrum of the second chromophore. 
     
     
         35 . The biophotonic composition of  claim 33  or  34 , wherein the first chromophore transfers energy to the second chromophore upon illumination with a light. 
     
     
         36 . The biophotonic composition of any one of  claims 33  to  35 , wherein the first chromophore is Eosin Y, and the second chromophore is one or more selected from Fluorescein, Phloxine B and Erythrosine B. 
     
     
         37 . The biophotonic composition of any one of  claims 33  to  36 , wherein the first chromophore is Fluorescein, and the second chromophore is Eosin Y. 
     
     
         38 . The biophotonic composition of any one of  claims 33  to  37 , wherein the second chromophore is present in an amount of from about 0.0001% to about 40% by weight of the total composition. 
     
     
         39 . The biophotonic composition of  claim 38 , wherein the second chromophore is present in an amount of from about 0.0001% to about 2% by weight of the total composition. 
     
     
         40 . The biophotonic composition of any one of  claims 33  to  39 , further comprising a third chromophore, wherein the third chromophore is a chlorophyll or saffron. 
     
     
         41 . The biophotonic composition of any one of  claims 1  to  40 , wherein the pH of the composition is within the range of from about 4.0 to about 7.0, from about 4.0 to about 6.5, or from about 4.0 to about 5.0. 
     
     
         42 . The biophotonic composition of any one of  claims 1  to  40 , wherein the pH of the composition is within the range of from about 6.0 to about 8.0 or about 6.5 to about 7.5. 
     
     
         43 . The biophotonic composition of any one of  claims 1  to  42 , wherein the composition further comprises one or more healing factors selected from the group consisting of glucosamine, hyaluronic acid, and allantoin. 
     
     
         44 . A method for promoting skin rejuvenation, comprising:
 applying topically to a skin a biophotonic composition according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         45 . A method of promoting wound healing, comprising:
 applying topically to a wound a biophotonic composition according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         46 . A method for biophotonic treatment of a skin disorder, comprising:
 applying topically to a target skin tissue afflicted with the skin disorder a biophotonic composition, according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         47 . A method for biophotonic treatment of acne, comprising:
 applying topically to a target tissue a biophotonic composition, according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         48 . A method for biophotonic treatment of acne scar, comprising:
 applying topically to a target tissue a biophotonic composition, according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         49 . A method of biophotonic treatment of an oral disease, comprising:
 applying topically to a target site a biophotonic composition, according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         50 . A method of biophotonic treatment of acute or chronic inflammation, comprising:
 applying topically to a target site a biophotonic composition, according to any one of  claims 1  to  43 ; and   illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.   
     
     
         51 . The method of any one of  claims 44  to  50 , further comprising removing the biophotonic composition after illumination. 
     
     
         52 . The method of any one of  claims 44  to  51 , wherein the biophotonic composition is illuminated for about 1 minute to about 30 minutes. 
     
     
         53 . The method of any one of  claims 44  to  51 , wherein the biophotonic composition is illuminated for less than about 20 minutes, about 15 minutes, about 10 minutes or about 5 minutes. 
     
     
         54 . The method of any one of  claims 44  to  53 , wherein the biophotonic composition is illuminated with actinic light. 
     
     
         55 . The method of any one of  claims 44  to  54 , wherein the biophotonic composition is illuminated with violet and/or blue light. 
     
     
         56 . A composition according to any one of  claims 1  to  43  for use in the treatment of wounds. 
     
     
         57 . A composition according to any one of  claims 1  to  43  for use in the treatment or prevention of skin disorders. 
     
     
         58 . A composition according to any one of  claims 1  to  43  for use in the treatment of acne. 
     
     
         59 . A composition according to any one of  claims 1  to  43  for use in the treatment of acne scars. 
     
     
         60 . A composition according to any one of  claims 1  to  43  for use in the treatment or prevention of an oral disease. 
     
     
         61 . A composition according to any one of  claims 1  to  43  for use in the treatment of acute or chronic inflammation. 
     
     
         62 . A kit comprising:
 a composition according to any one of  claims 1  to  43  and   one or more of a light source for activating the first chromophore, instructions for use of the composition and/or the light source, a dressing, and a device for applying and/or removing the composition from a treatment area.   
     
     
         63 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment of wounds. 
     
     
         64 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment or prevention of skin disorders. 
     
     
         65 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment of acne. 
     
     
         66 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment of acne scars. 
     
     
         67 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment or prevention of an oral disease. 
     
     
         68 . Use of a composition according to any one of  claims 1  to  43  in the manufacture of a medicament for the treatment of acute or chronic inflammation.