Composition for treating or preventing skin pigmentation

Abstract

The present invention provides a composition for treating or preventing skin pigmentation, which contains fibroblasts as an active ingredient, wherein the fibroblasts are those fibroblasts which are less damaged than fibroblasts localized in a site where the skin pigmentation occurs, and the composition is characterized by being intended to be applied to a site where the pigmentation occurs or a dermis tissue around the site.

1 . A composition for treatment or prevention of skin pigmentation, containing fibroblasts as an active ingredient, wherein:
 the fibroblasts are fibroblasts with less damage than fibroblasts localized at the site of skin pigmentation, and   the composition is applied to the site of pigmentation or its surrounding dermal tissue.   
     
     
         2 . The composition according to  claim 1 , wherein the pigmentation is from one or more conditions selected from the group consisting of senile pigmentation spots, seborrheic keratosis, Chloasma, freckles and floriform pigmented spots. 
     
     
         3 . The composition according to  claim 1 , wherein the fibroblasts are derived from biological tissue of a site with low light exposure or no light exposure. 
     
     
         4 . The composition according to  claim 1 , wherein the fibroblasts are derived from a tissue selected from the group consisting of the gluteal region, abdominal region, thorax, femoral region, upper arm, dorsal region, gingiva, oral mucosa, scalp, palms, foot soles and auricle rear. 
     
     
         5 . The composition according to  claim 1 , wherein the fibroblasts are autologous fibroblasts. 
     
     
         6 . The composition according to  claim 1 , wherein the fibroblasts are fibroblasts differentiated from pluripotent stem cells or tissue stem cells. 
     
     
         7 . The composition according to  claim 1 , wherein the fibroblasts have lower expression of a cell senescence marker than fibroblasts localized at the site of skin pigmentation. 
     
     
         8 . The composition according to  claim 7 , wherein the cell senescence marker is one or more selected from the group consisting of senescent acidic β-galactosidase (SA-βgal), cell cycle check mechanism-associated factor and cell senescence-associated secretory phenotype (SASP) factor. 
     
     
         9 . The composition according to  claim 1 , which is to be applied by cell therapy.