Processes for Preparing Quinoline Compounds and Pharmaceutical Compositions Containing Such Compounds

Abstract

The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.

1 - 34 . (canceled) 
     
     
         35 . Compound IA which is essentially free of contaminants or byproducts. 
       
         
           
           
               
               
           
         
       
     
     
         36 . Compound IA of  claim 35  admixed with 200 ppm or less of contaminants or byproducts. 
     
     
         37 . Compound IA of  claim 35 , wherein the contaminant or byproduct is 6,7-dimethoxy-quinoline-4-ol. 
     
     
         38 . Compound IA of  claim 37  admixed with 200 ppm or less, 100 ppm or less, 50 ppm or less, 25 ppm or less, 10 ppm or less, 5 ppm or less, 2.5 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 
     
     
         39 . Compound IB which is essentially free of contaminants or byproducts. 
       
         
           
           
               
               
           
         
       
     
     
         40 . Compound IB of  claim 39  admixed with 200 ppm or less of contaminants or byproducts. 
     
     
         41 . Compound IB of  claim 39 , wherein the contaminant or byproduct is 6,7-dimethoxy-quinoline-4-ol. 
     
     
         42 . Compound IB of  claim 41  admixed with 200 ppm or less, 100 ppm or less, 50 ppm or less, 25 ppm or less, 10 ppm or less, 5 ppm or less, 2.5 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 
     
     
         43 . Compound IB of  claim 42 , wherein Compound IB is crystalline. 
     
     
         44 . Compound IB of  claim 43 , wherein Compound IB is in form N−1. 
     
     
         45 . Compound IB of  claim 43 , wherein Compound IB is in form N−2.