Peroxide removal from drug delivery vehicle

Abstract

The present invention is related to methods for lowering peroxide levels in sucrose acetate isobutyrate formulations and to composition used in and formed by such methods.

1 .- 25 . (canceled) 
     
     
         26 . A formulation comprising:
 a local anesthetic;   sucrose acetate isobutyrate; and   peroxide,   wherein the peroxide is present in the formulation at a level ranging from 2.6 ppm to 20 ppm.   
     
     
         27 . The formulation of  claim 26 , wherein the peroxide is present in the formulation at a level ranging from 5 ppm to 20 ppm. 
     
     
         28 . The formulation of  claim 26 , wherein the peroxide is present in the formulation at a level ranging from 10 ppm to 20 ppm. 
     
     
         29 . The formulation of  claim 26 , wherein the peroxide is present in the formulation at a level ranging from 2.6 ppm to 10 ppm. 
     
     
         30 . The formulation of  claim 26 , wherein the peroxide is present in the formulation at a level ranging from 5 ppm to 10 ppm. 
     
     
         31 . The formulation of  claim 26 , further comprising a pharmaceutically acceptable solvent. 
     
     
         32 . The formulation of  claim 27 , further comprising a pharmaceutically acceptable solvent. 
     
     
         33 . The formulation of  claim 28 , further comprising a pharmaceutically acceptable solvent. 
     
     
         34 . The formulation of  claim 29 , further comprising a pharmaceutically acceptable solvent. 
     
     
         35 . The formulation of  claim 26 , further comprising a solvent comprising hexane, ethyl acetate, ethanol, benzyl benzoate, N-methyl pyrrolidone, or isopropyl alcohol, or a combination thereof. 
     
     
         36 . A method of administering a local anesthetic, comprising administering the formulation of  claim 26 . 
     
     
         37 . A formulation comprising:
 a local anesthetic;   sucrose acetate isobutyrate; and   peroxide,   wherein the peroxide is present in the formulation at a level ranging from 2.6 ppm to 20 ppm, and   wherein the formulation is polymer-free.   
     
     
         38 . The formulation of  claim 37 , wherein the peroxide is present in the formulation at a level ranging from 5 ppm to 20 ppm. 
     
     
         39 . The formulation of  claim 37 , wherein the peroxide is present in the formulation at a level ranging from 5 ppm to 20 ppm. 
     
     
         40 . The formulation of  claim 37 , wherein the peroxide is present in the formulation at a level ranging from 2.6 ppm to 10 ppm. 
     
     
         41 . The formulation of  claim 37 , wherein the peroxide is present in the formulation at a level ranging from 5 ppm to 10 ppm. 
     
     
         42 . The formulation of  claim 37 , further comprising a pharmaceutically acceptable solvent. 
     
     
         43 . The formulation of  claim 38 , further comprising a pharmaceutically acceptable solvent. 
     
     
         44 . The formulation of  claim 39 , further comprising a pharmaceutically acceptable solvent. 
     
     
         45 . A method of administering a local anesthetic, comprising administering the formulation of  claim 37 .